Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Masakazu Mizobe"'
Autor:
Masao Kobayashi, Hiroyuki Yoshino, Masakazu Mizobe, Takashi Ishibashi, Kengo Ikegami, Hiroaki Kubo
Publikováno v:
Journal of Controlled Release. 59:361-376
A series of dog studies were performed to examine the in vitro/in vivo relationship of drug release behavior of the newly developed colon-targeted delivery capsule (CTDC). The four kinds of CTDCs containing theophylline, each of which has a different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042c86eb685dc64998b7f284e91de617
https://doi.org/10.1016/s0168-3659(99)00005-x
https://doi.org/10.1016/s0168-3659(99)00005-x
Publikováno v:
Life Sciences. 63:1097-1108
To clarify the mechanism of the species difference in the metabolism of bisoprolol enantiomers, in vitro metabolic studies were performed using dog liver microsomes and human cytochrome P450 (CYP) isoforms. The O-deisopropylation of bisoprolol enanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcab0a7f0359e24bd7a8ed73c95d6c3
https://doi.org/10.1016/s0024-3205(98)00371-3
https://doi.org/10.1016/s0024-3205(98)00371-3
Publikováno v:
International Journal of Pharmaceutics. 168:31-40
A new capsule-type dosage form was investigated for colon-targeted delivery of drugs. The system was designed by imparting a timed-release function and a pH-sensing function to a hard gelatin capsule. The technical characteristics of the system are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70afa2b965a022f6f8214ec7d138755c
https://doi.org/10.1016/s0378-5173(98)00082-9
https://doi.org/10.1016/s0378-5173(98)00082-9
Publikováno v:
Journal of Pharmaceutical Sciences. 87:531-535
□ Colonic drug delivery is intended for local or systemic therapies. The lack of predictive in vitro or animal model leads to considerable time delays in colonic product development. The objective of this scintigraphic study was to provide “proof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8247f9f40bc06c2ae85756115e04e22
https://doi.org/10.1021/js9704588
https://doi.org/10.1021/js9704588
Publikováno v:
Journal of Pharmaceutical Sciences. 87:289-294
The plasma concentrations and urinary excretions of bisoprolol enantiomers in four Japanese male healthy volunteers after a single oral administration of 20 mg of racemic bisoprolol were evaluated. The AUC(infinity) and elimination half-life of (S)-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb8a435888e7ad34d9bbb2d8d03da87
https://doi.org/10.1021/js970316d
https://doi.org/10.1021/js970316d
Autor:
Masakazu Mizobe, Hiroaki Kubo
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:460-463
We investigated the usefulness and efficiency of the co-grinding method with D-mannitol to improve the bioavailability of a sparingly water-soluble drug, (+/-)-5-[[2-(2-naphthalenylmethyl)-5-benzoxazolyl]methyl]-2, 4-thiazolidinedione (174), and comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406d625b546146e699556ec196985699
https://doi.org/10.1248/bpb.20.460
https://doi.org/10.1248/bpb.20.460
Publikováno v:
Biological and Pharmaceutical Bulletin. 19:741-747
To improve the bioavailability of the sparingly water-soluble drug, 1-(3,4-dimethoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8- trimethoxynaphthalene (TA-7552), the usefulness of the co-grinding method with D-mannitol was investigated. The co-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e62fdee9cb4a9546a7a9bc8514b38d7
https://doi.org/10.1248/bpb.19.741
https://doi.org/10.1248/bpb.19.741
Publikováno v:
Biological and Pharmaceutical Bulletin. 18:64-69
In order to obtain a rational explanation and analytical method of the unique pharmacokinetic behaviors of imidapril and imidaprilat in human, a new pharmacokinetic model was designed by introducing a saturable-reversible angiotensin I converting enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0f9d9433242835e800f851cde3672
https://doi.org/10.1248/bpb.18.64
https://doi.org/10.1248/bpb.18.64
Publikováno v:
Journal of Pharmaceutical Sciences. 79:963-967
To evaluate oral mucosal absorption of drugs in dogs, a newly designed in situ perfusion system with a circulating perfusion chamber was developed. The utility of the perfusion system was investigated by using three drugs: salicylic acid (SA), sulfad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23565161dfae0c6d4f1d3c05bb906887
https://doi.org/10.1002/jps.2600791103
https://doi.org/10.1002/jps.2600791103
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 529:500-506
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6aabee2e3199f8a6b971a4d5d1ebcef
https://doi.org/10.1016/s0378-4347(00)83861-x
https://doi.org/10.1016/s0378-4347(00)83861-x