Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Masakazu Hatanaka"'
Publikováno v:
Liver. 8:208-212
— To elucidate the role of oncogene expression in hepatocarcinogenesis, we examined the expression of 8 cellular oncogenes by dot blot and/or northern blot analysis in neoplastic, cirrhotic and non-cirrhotic human liver tissues obtained at surgery.
Autor:
Kenta Yoshiura, Masaya Higuchi, Masayasu Oie, Yuetsu Tanaka, Naoki Mori, Masahiro Fujii, Minako Ohashi, Masakazu Hatanaka, Robert J. Coffey, Mamoru Sakurai, Masaya Fukushi, Makoto Uchiyama
Publikováno v:
Virology. 320:52-62
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL), whereas the closely related virus HTLV-2 has not been associated with such malignant conditions. HTLV-1 Tax1 oncoprotein transforms a rat fibroblast ce
Autor:
Kiyoshi Habu, Junko Nakayama-Yamada, Masahide Asano, Shinobu Saijo, Keiko Itagaki, Reiko Horai, Hiroaki Yamamoto, Toyozo Sekiguchi, Tetsuya Nosaka, Masakazu Hatanaka, Yoichiro Iwakura
Publikováno v:
The Journal of Immunology. 162:2956-2963
We previously reported that inflammatory arthropathy resembling rheumatoid arthritis (RA) develops among transgenic mice carrying the long terminal repeat (LTR)-env-pX-LTR region of human T cell leukemia virus type I (LTR-pX-Tg mice). Because four ge
Autor:
Dominic J. Wells, Guglielmo Scarlato, George Dickson, Manuela Sironi, Nereo Bresolin, Masakazu Hatanaka, Shoji Yamaoka, Ariberto Fassati, Alessandra Bardoni
Publikováno v:
Human Gene Therapy. 9:2459-2468
The use of retroviral vectors (RVs) derived from the murine oncoretroviruses for gene therapy is associated with the risk of malignant transformation of infected cells and ectopic expression of the proteins of interest. Targeting retroviral vectors t
Autor:
Makoto Noda, Kunitada Shimotohno, Kunihiro Ueda, Mitsuko Masutani, Masakazu Hatanaka, Yasuo Ariumi, Terry D. Copeland
Publikováno v:
FEBS Letters. 436:288-292
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme, which is activated by DNA strand breaks. Although PARP is known to be cleaved by the cysteine protease, caspase-3/CPP32, during apoptosis, signal cascade which regulates the PARP activity has no
Publikováno v:
FEBS Letters. 423:25-30
The HTLV-I provirus contains two different promoters: the classical retroviral promoter in the 5′ long terminal repeat (LTR) and our previously identified second promoter in the pol gene just upstream of the ATG codon of the tax gene. Here, we demo
Autor:
Mike Carson, Guang-da Lin, Masatoshi Maki, Lei Jin, Kevin K.W. Wang, Emiko Takano, Sthanam V.L. Narayana, Po-Wai Yuen, Lawrence J. DeLucas, Debasish Chattopadhyay, Masakazu Hatanaka
Publikováno v:
Nature Structural Biology. 4:539-547
The three dimensional structure of calcium-bound domain VI of porcine calpain has been determined to 1.9 A resolution. The crystal structure reveals five EF-hands, one more than previously suggested. There are two EF-hand pairs, one pair (EF1-EF2) di