Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Masakatsu Eguchi"'
Autor:
Brian Leber, Borko Tanasijevic, Mickie Bhatia, Ruth M. Risueño, Monica Graham, Jennifer Russell, Ronan Foley, Tony J. Collins, Allison L. Boyd, Masakatsu Eguchi, Michael Trus, Ryan R. Mitchell, Lili Aslostovar, Luca Orlando, Zoya Shapovalova, Kyle R. Salci, Diana Golubeva, Anargyros Xenocostas, Yannick D. Benoit
Publikováno v:
Cell chemical biology. 24(7)
Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated pathways that support transformed CSCs, such as Wnt/β-catenin signaling,
Publikováno v:
Medicinal Chemistry. 1:467-472
Inherited and somatic mutations in the APC gene, a human tumor-suppressor, occur in a large percentage of colon cancers, leading to elevated levels of nuclear beta-Catenin, and to activation of TCF/beta-Catenin-responsive genes including cyclin D1 an
Publikováno v:
PROCEEDINGS OF CIVIL ENGINEERING IN THE OCEAN. 21:987-992
When construction of underground facilities were planned at the sites where the ground is composed of soft sediments with high water level, groundwater management plans should be made to keep the excavation construction site safe and dry, and to avoi
Autor:
Jia-Ling Teo, Jong Ryul Ha, Randall T. Moon, Hong Ma, Katayoon H. Emami, Sung Hwan Moon, Hak Yeop Kim, Kwang Won Jeong, Se Woong Oh, Masakatsu Eguchi, Cu Nguyen, Michael G. Kahn, Dae Hoon Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 101:12682-12687
Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells wi
Autor:
Michael G. Kahn, William R. Henderson, Cu Nguyen, Emil Y. Chi, Jia Ling Teo, Masakatsu Eguchi, Michael McMillan
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 6:611-621
There is increasing evidence that redox regulation of transcription, particularly activator protein-1 (AP-1) and nuclear factor kappa B (NF-kappaB), is important in inflammatory diseases. Human thioredoxin (TRX), a member of the oxidoreductase superf
Autor:
Cu Nguyen, Michael G. Kahn, Masakatsu Eguchi, Emil Y. Chi, Jia Ling Teo, William R. Henderson, Akihisa Matsuda
Publikováno v:
Proceedings of the National Academy of Sciences. 100:1169-1173
Asthma is characterized by an oxidant/antioxidant imbalance in the lungs leading to activation of redox-sensitive transcription factors, nuclear factor κB (NF-κB), and activator protein-1 (AP-1). To develop therapeutic strategies for asthma, we use
Autor:
Michael G. Kahn, Masakatsu Eguchi
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 2:447-462
The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years
Publikováno v:
Journal of Medicinal Chemistry. 45:1395-1398
We have identified a mu-selective opioid receptor agonist without a cationic amino group in the molecule from libraries of bicyclic beta-turn peptidomimetics. The biologically active conformation of the lead is proposed to mimic an endomorphin type I
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1749-1754
A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides
Publikováno v:
Tetrahedron Letters. 34:915-918
Rhodium-catalyzed silylformylation and amidocarbonylation are applied to the syntheses of pyrrolizidine alkaloids, (±)-isoretronecanol and (±)-trachelanthamidine, from 5-ethynyl-2-pyrrolidinone.