Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Masaji Kasai"'
Autor:
Hajime Takashima, Atsushi Yoshimori, Eiji Honda, Tomonori Taguri, Jun Ozawa, Masaji Kasai, Satoshi Shuto, Dai Takehara
Publikováno v:
ACS Omega, Vol 6, Iss 40, Pp 26601-26612 (2021)
Externí odkaz:
https://doaj.org/article/2f136a2a8e164a58908361d488e302f5
Autor:
Takeo Nakaya, Kenichi Aizawa, Yuki Taguchi, Kentaro Tsuji, Sachi Sekine, Kazuhiro Murakami, Masaji Kasai, Hirofumi Nakano, Yasumitsu Kondoh, Shingo Dan, Atsushi Yoshimori, Hiroyuki Kouji, Dai Takehara, Toru Suzuki, Hiroyuki Osada, Masayuki Murata, Akira Tanaka, Ryozo Nagai
Publikováno v:
ACS Med Chem Lett
[Image: see text] Krüppel-like factor 5 (KLF5) is a potential target for anticancer drugs. However, as an intrinsically disordered protein (IDP) whose tertiary structure cannot be solved, innovative strategies are needed. We focused on its hydrophob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48abf437121ea5a9f9a761efa149c375
https://doi.org/10.1021/acsmedchemlett.1c00721
https://doi.org/10.1021/acsmedchemlett.1c00721
Autor:
Eiji Honda, Tomonori Taguri, Atsushi Yoshimori, Dai Takehara, Jun Ozawa, Masaji Kasai, Hajime Takashima, Satoshi Shuto
Publikováno v:
ACS Omega, Vol 6, Iss 40, Pp 26601-26612 (2021)
ACS Omega
ACS Omega
Protein–protein interactions (PPIs) are fundamentally important and challenging drug targets. Peptidomimetic molecules of various types have been developed to modulate PPIs. A particularly promising drug discovery strategy, structural peptidomimeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf9f44a14f478e8e34dab16b12a8e51
https://doi.org/10.1021/acsomega.1c03967
https://doi.org/10.1021/acsomega.1c03967
Autor:
Yuuka Hirao, Hiroyuki Neyama, Atsushi Yoshimori, Hirofumi Nakano, Yoshifumi Nishimura, Hiroshi Ueda, Masaji Kasai, Jun-ichi Kurita, Tadashi Mishina, Hiroyuki Kouji
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4705-4709
The neuron-restrictive silencing factor NRSF/REST binds to neuron-restrictive silencing elements in neuronal genes and recruits corepressors such as mSin3 to inhibit epigenetically neuronal gene expression. Because dysregulation of NRSF/REST is relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deac4366dac678cc9a8ebcf84d2d3456
https://doi.org/10.1016/j.bmcl.2017.09.006
https://doi.org/10.1016/j.bmcl.2017.09.006
Autor:
Masaji Kasai, Motomichi Kono
Publikováno v:
Synlett. 1992:778-790
The studies on the chemistry of mitomycins are described : i) identification and structural elucidation of mitomycins D, E, F, G, I, J, K, L, M, albomitomycin A, and isomitomycin A from the fermentation broth; ii) derivation of mitomycins structurall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675e4c1204adc24f7c277424162478d1
https://doi.org/10.1055/s-1992-21490
https://doi.org/10.1055/s-1992-21490
Autor:
Kenji Fujino, Yoshiaki Masuda, Iwao Chujo, Shin-ichiro Mohri, Masaji Kasai, Sachiko Kato, Takehiro Ogasa
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:3273-3286
The two new synthetic routes to 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5H- benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxylic acid (1), a novel immunosuppressant KF20444, are described. The seven-membered ring construction from 2-[4-(2-fluorophenyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c9fa93df1f93d171446273f48e0f50
https://doi.org/10.1016/s0968-0896(01)00238-3
https://doi.org/10.1016/s0968-0896(01)00238-3
Autor:
and Shin-ichiro Mohri, Hitoshi Takami, Masaji Kasai, Takehiro Ogasa, Kenji Fujino, Toshiyuki Atsumi
Publikováno v:
Organic Process Research & Development. 5:426-433
An efficient route suitable for a large-scale preparation of KF31327 (1), a potent phosphodiesterase V inhibitor, has been developed. We selected 7-chloro-2,4(1H,3H)-quinazolinedione (15) as a starting material, which gave the desired 6-nitro compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c044eba18508ee4c26c138395b1b805a
https://doi.org/10.1021/op010025y
https://doi.org/10.1021/op010025y
Publikováno v:
Organic Process Research & Development. 4:349-352
In dipeptide production, it was observed that a water solution of a peptide became turbid. The origin of turbidity was monitored and identified by LC-MS analysis. The impurities, derived from natural rubber gloves, and polyethylene bags caused the tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64284bc22226cf573c33ee31ea180068
https://doi.org/10.1021/op000026a
https://doi.org/10.1021/op000026a
Publikováno v:
Organic Process Research & Development. 4:147-152
A large-scale manufacturing method of l-alanyl-l-glutamine used for a component of parenteral nutrition has been studied. The method consisted of a reaction of d-2-chloro- or d-2-bromopropionic acid with thionyl chloride and Schotten−Baumann reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ca196f588ac29d54f813ad0ad3e0c9
https://doi.org/10.1021/op990079w
https://doi.org/10.1021/op990079w
Autor:
Masaji Kasai, Masanori Ikuta, Nobuyuki Kato, Shinji Tomioka, Sachiko Kato, Yukihiro Kuge, Toru Sugaya, Takashi Mimura
Publikováno v:
Synthesis. 1999:947-952
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b96d19dda33404c31472df71cc04eeb1
https://doi.org/10.1055/s-1999-3494
https://doi.org/10.1055/s-1999-3494