Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Masaji, Ishiguro"'
Autor:
Takashi Sasaki, Moeko Mita, Naho Ikari, Ayane Kuboyama, Shuzo Hashimoto, Tatsuya Kaneko, Masaji Ishiguro, Makoto Shimizu, Jun Inoue, Ryuichiro Sato
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179226 (2017)
TGR5, a member of the G protein-coupled receptor (GPCR) family, is activated by bile acids. Because TGR5 promotes energy expenditure and improves glucose homeostasis, it is recognized as a key target in treating metabolic diseases. We previously show
Externí odkaz:
https://doaj.org/article/c49ab6b0817040e490694a029bf30fe7
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 1, Pp 57-65 (2010)
The present study was designed to examine the binding affinity and functional potency of selective angiotensin II type 1 (AT1)-receptor antagonists towards specific mutants of AT1 receptor using site-directed mutagenesis. We also compared our results
Externí odkaz:
https://doaj.org/article/64c0c3d822754811aade95eeaf49bc2a
Autor:
Yuko Nagaoka, Maruf Ahmed, Murad Hossain, Mohiuddin Ahmed Bhuiyan, Masaji Ishiguro, Takashi Nakamura, Masatomo Watanabe, Takafumi Nagatomo
Publikováno v:
Journal of Pharmacological Sciences, Vol 106, Iss 1, Pp 114-120 (2008)
Computer simulations of the human α 1d-adrenergic receptor (α 1d-AR) based on the crystal structure of rhodopsin have been combined with experimental site-directed mutagenesis to investigate the role of residues in the transmembrane domains in anta
Externí odkaz:
https://doaj.org/article/4a857321d7bc484782b37c71a472bfd9
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126921 (2015)
Among proteins utilized as sweeteners, neoculin and miraculin are taste-modifying proteins that exhibit pH-dependent sweetness. Several experiments on neoculin have shown that His11 of neoculin is responsible for pH dependence. We investigated the mo
Externí odkaz:
https://doaj.org/article/a843986fab8d45c3a18de7c27df87407
Autor:
Maruf Ahmed, Habib Abul Muntasir, Murad Hossain, Masaji Ishiguro, Tadazumi Komiyama, Ikunobu Muramatsu, Hitoshi Kurose, Takafumi Nagatomo
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 2, Pp 167-172 (2006)
We obtained a new mutant of the β1-adrenergic receptor (β1-AR) by point mutations that can constitutively activate β1-AR. Aspartate104 of the β1-AR in the 2nd transmembrane was replaced with alanine. The β1-AR mutant expressed in human embryonic
Externí odkaz:
https://doaj.org/article/3d634c84f06347f5abb44f6077455725
Autor:
Habib Abul Muntasir, Mohiuddin Ahmed Bhuiyan, Masaji Ishiguro, Masanobu Ozaki, Takafumi Nagatomo
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 2, Pp 189-195 (2006)
Mutations producing constitutively active G-protein coupled receptors have been found in the pathophysiology of several diseases, implying that inverse agonists at the constitutively active receptors may have preferred therapeutic applications. Becau
Externí odkaz:
https://doaj.org/article/89c41733033a43e4a3430afc5334d2c2
Autor:
Kazuya Ishizawa, Nobuhisa Isaka, Minoru Tamiya, Atsushi Hasegawa, Takaaki Kitazawa, Mayu Ikeda, Masaji Ishiguro, Saki Kawada
Publikováno v:
Bulletin of the Chemical Society of Japan. 92:1474-1494
We describe here the syntheses of velutinol A (1) and the structurally similar compounds 2–4 sharing a highly oxygenated seco-pregnane cage-like structure. The synthesis of velutinol A (1, 15,16-se...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e591abf493375dfd973631681e551db8
https://doi.org/10.1246/bcsj.20190048
https://doi.org/10.1246/bcsj.20190048
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2345-2367
Novel carbohydrate mimics were designed which contain two 5a-carba-d-glucose residues, one each at reducing and nonreducing end, and thus these mimics are 5a,5a'-dicarba-d-glucobioses. Dicarbadisaccharides have attractive features such as stability a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e698e94fddca49e740ba3a68b88495a
https://doi.org/10.1016/j.bmc.2018.12.027
https://doi.org/10.1016/j.bmc.2018.12.027
Autor:
Katsuyoshi Masuda, Ayako Koizumi, Ken-ichiro Nakajima, Takaharu Tanaka, Keiko Abe, Takumi Misaka, Masaji Ishiguro
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35380 (2012)
One of the most distinctive features of human sweet taste perception is its broad tuning to chemically diverse compounds ranging from low-molecular-weight sweeteners to sweet-tasting proteins. Many reports suggest that the human sweet taste receptor
Externí odkaz:
https://doaj.org/article/7f4ae56ef4a74553a0a186d7071dbcce
Autor:
Masaji Ishiguro
Publikováno v:
Japanese Journal of Pesticide Science. 43:54-59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d70fc5b48caf1faf4a275f2a1c979541
https://doi.org/10.1584/jpestics.w18-20
https://doi.org/10.1584/jpestics.w18-20