Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Masahito Yoshihara"'
Autor:
Andrea Coschiera, Masahito Yoshihara, Gilbert Lauter, Sini Ezer, Mariangela Pucci, Haonan Li, Alan Kavšek, Christian G. Riedel, Juha Kere, Peter Swoboda
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-28 (2024)
Abstract Background Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of cilia
Externí odkaz:
https://doaj.org/article/033a80d3f6414de2aaf7463656f7bd0b
Autor:
Kayoko Hosaka, Chenchen Wang, Shiyue Zhang, Xue Lv, Takahiro Seki, Yin Zhang, Xu Jing, Jieyu Wu, Qiqiao Du, Xingkang He, Yulong Fan, Xuan Li, Makoto Kondo, Masahito Yoshihara, Hong Qian, Lihong Shi, Ping Zhu, Yuanfu Xu, Yunlong Yang, Tao Cheng, Yihai Cao
Publikováno v:
Cancer Communications, Vol 43, Iss 6, Pp 637-660 (2023)
Abstract Background Tumors possess incessant growth features, and expansion of their masses demands sufficient oxygen supply by red blood cells (RBCs). In adult mammals, the bone marrow (BM) is the main organ regulating hematopoiesis with dedicated m
Externí odkaz:
https://doaj.org/article/8df481223bdb46a19afced0251c70f02
Autor:
Daniel F. Kaemena, Masahito Yoshihara, Meryam Beniazza, James Ashmore, Suling Zhao, Mårten Bertenstam, Victor Olariu, Shintaro Katayama, Keisuke Okita, Simon R. Tomlinson, Kosuke Yusa, Keisuke Kaji
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Induced pluripotent stem cell (iPSC) reprogramming is inherently inefficient. Here the authors identify 24 reprogramming roadblock genes through a CRISPR/Cas9-mediated genome-wide knockout screen including a KRAB-ZFP Zfp266, knockout of which consist
Externí odkaz:
https://doaj.org/article/4fba6b2d47e34448aee4bad9013f96d3
Autor:
Lisa Gawriyski, Eeva-Mari Jouhilahti, Masahito Yoshihara, Liangru Fei, Jere Weltner, Tomi T. Airenne, Ras Trokovic, Shruti Bhagat, Mari H. Tervaniemi, Yasuhiro Murakawa, Kari Salokas, Xiaonan Liu, Sini Miettinen, Thomas R. Bürglin, Biswajyoti Sahu, Timo Otonkoski, Mark S. Johnson, Shintaro Katayama, Markku Varjosalo, Juha Kere
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106172- (2023)
Summary: The paired-like homeobox transcription factor LEUTX is expressed in human preimplantation embryos between the 4- and 8-cell stages, and then silenced in somatic tissues. To characterize the function of LEUTX, we performed a multiomic charact
Externí odkaz:
https://doaj.org/article/1b78c910dbd44d44b717a1317ad6a139
Autor:
Yuta Yamamura, Kengo Furuichi, Yasuhiro Murakawa, Shigeki Hirabayashi, Masahito Yoshihara, Keisuke Sako, Shinji Kitajima, Tadashi Toyama, Yasunori Iwata, Norihiko Sakai, Kazuyoshi Hosomichi, Philip M. Murphy, Atsushi Tajima, Keisuke Okita, Kenji Osafune, Shuichi Kaneko, Takashi Wada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract PAX2 is a transcription factor essential for kidney development and the main causative gene for renal coloboma syndrome (RCS). The mechanisms of PAX2 action during kidney development have been evaluated in mice but not in humans. This is a c
Externí odkaz:
https://doaj.org/article/441f6fd5b00847cfaaed60ac37342f8f
Autor:
Sanna Vuoristo, Shruti Bhagat, Christel Hydén-Granskog, Masahito Yoshihara, Lisa Gawriyski, Eeva-Mari Jouhilahti, Vipin Ranga, Mahlet Tamirat, Mikko Huhtala, Ida Kirjanov, Sonja Nykänen, Kaarel Krjutškov, Anastassius Damdimopoulos, Jere Weltner, Kosuke Hashimoto, Gaëlle Recher, Sini Ezer, Priit Paluoja, Pauliina Paloviita, Yujiro Takegami, Ai Kanemaru, Karolina Lundin, Tomi T. Airenne, Timo Otonkoski, Juha S. Tapanainen, Hideya Kawaji, Yasuhiro Murakawa, Thomas R. Bürglin, Markku Varjosalo, Mark S. Johnson, Timo Tuuri, Shintaro Katayama, Juha Kere
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104137- (2022)
Summary: Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the chromatin accessibility of non-coding DNA and activates thousands of newly i
Externí odkaz:
https://doaj.org/article/e20d78e8cdab451083fb4b3f94c08b7f
Autor:
Sini Ezer, Masahito Yoshihara, Shintaro Katayama, Carsten Daub, Hannes Lohi, Kaarel Krjutskov, Juha Kere
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100995- (2021)
Summary: We have developed a protocol for barcoded cDNA libraries of 48 samples to study gene expression across tissues in the domestic dog, Canis familiaris, by modifying the Single-Cell Tagged Reverse Transcription (STRT) protocol (Islam et al., 20
Externí odkaz:
https://doaj.org/article/d4999bfde08e446a941caa5a98b91b2b
Autor:
Magdalena Wagner, Masahito Yoshihara, Iyadh Douagi, Anastasios Damdimopoulos, Sarita Panula, Sophie Petropoulos, Haojiang Lu, Karin Pettersson, Kerstin Palm, Shintaro Katayama, Outi Hovatta, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The outer lining or cortex of the human ovary determines fertility and has been postulated to contain oogonial stem cells. Here, the authors generate a single-cell map of the adult human ovarian cortex and show that DDX4 labels perivascular cells but
Externí odkaz:
https://doaj.org/article/e6b0eb324cf54b6ca3c0777743fe76df
Autor:
Eduard Daura, Saara Tegelberg, Masahito Yoshihara, Christopher Jackson, Francesca Simonetti, Katri Aksentjeff, Sini Ezer, Paula Hakala, Shintaro Katayama, Juha Kere, Anna-Elina Lehesjoki, Tarja Joensuu
Publikováno v:
Neurobiology of Disease, Vol 156, Iss , Pp 105418- (2021)
Cystatin B (CSTB) acts as an inhibitor of cysteine proteases of the cathepsin family and loss-of-function mutations result in human brain diseases with a genotype-phenotype correlation. In the most severe case, CSTB-deficiency disrupts brain developm
Externí odkaz:
https://doaj.org/article/e25ef9ea29f0476d9ed82d1d631b1cf3
Autor:
Masahito Yoshihara, Susumu Hara, Motokazu Tsujikawa, Satoshi Kawasaki, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji, Kohji Nishida
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 175-186 (2017)
Corneal endothelial cells (CECs) are essential for maintaining the clarity of the cornea. Because CECs have limited proliferative ability, interest is growing in their potentially therapeutic regeneration from pluripotent stem cells. However, the mol
Externí odkaz:
https://doaj.org/article/661cbde0d5ce4c64bf32cd26f39fe981