Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Masahito Wakita"'
Autor:
Norio Akaike, Ayaka Hamamoto, Masahito Wakita, Min-Chul Shin, Takatoshi Yamamoto, Toshitaka Yamaga, Kensaku Anraku, Kiku Nonaka
Publikováno v:
Toxins, Vol 5, Iss 1, Pp 193-202 (2013)
The amounts of puffer toxin (tetrodotoxin, TTX) extracted from the fresh and the traditional Japanese salted and fermented “Nukazuke” and “Kasuzuke” ovaries of Takifugu stictonotus (T. stictonotus) were quantitatively analyzed in the voltage-
Externí odkaz:
https://doaj.org/article/923f39bddac8495c8b5e113a6f4258a7
Autor:
Min-Chul Shin, Masahito Wakita, Du-Jie Xie, Toshitaka Yamaga, Satomi Iwata, Yasushi Torii, Tetsuhiro Harakawa, Akihiro Ginnaga, Shunji Kozaki, Norio Akaike
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 1, Pp 33-42 (2012)
Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system (CNS) neurons. The Na+ current (INa) is of major interest because it acts as the trigger for ma
Externí odkaz:
https://doaj.org/article/62f5abd3ff5043848867d43c9a9733ca
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 1, Pp 75-81 (2012)
Our recent study showed a possibility that newly developed A2 type botulinum toxin (A2NTX) inhibits both spontaneous and evoked transmitter release from inhibitory (glycinergic or GABAergic) and excitatory (glutamatergic) nerve terminals using rat sp
Externí odkaz:
https://doaj.org/article/f57975b6057445eeb545b6d14c58c105
Publikováno v:
Journal of Neurophysiology. 120:1264-1273
The current electrophysiological study investigated the functional roles of high- and low-voltage-activated Ca2+ channel subtypes on glutamatergic small mossy fiber nerve terminals (SMFTs) that synapse onto rat hippocampal CA3 neurons. Experiments co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b01283913a3459b4f7d0bf79d26eab5
https://doi.org/10.1152/jn.00571.2017
https://doi.org/10.1152/jn.00571.2017
Publikováno v:
Chemosphere. 184:337-346
4,5-Dichloro-2-octyl-4-isothiazolin-3-one (DCOIT) is an alternative to organotin antifoulants, such as tributyltin and triphenyltin. Since DCOIT is found in harbors, bays, and coastal areas worldwide, this chemical compound may have some impacts on e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17edbeff39ee61cca369f2230a85477a
https://doi.org/10.1016/j.chemosphere.2017.05.158
https://doi.org/10.1016/j.chemosphere.2017.05.158
Publikováno v:
Brain Research Bulletin. 118:34-45
We evaluated the effects of N2O on synaptic transmission using a preparation of mechanically dissociated rat hippocampal CA3 neurons that allowed assays of single bouton responses evoked from native functional nerve endings. We studied the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec5c6460548e129446544e1f449bd46
https://doi.org/10.1016/j.brainresbull.2015.09.001
https://doi.org/10.1016/j.brainresbull.2015.09.001
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:246-259
Levetiracetam (LEV) is an antiepileptic drug with a unique but as yet not fully resolved mechanism of action. Therefore, by use of a simplified rat-isolated nerve-bouton preparation, we have investigated how LEV modulates glutamatergic transmission f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b879b9c79fe12fba606aa47b7abac49
https://doi.org/10.1124/jpet.113.208751
https://doi.org/10.1124/jpet.113.208751
Autor:
Norio Akaike, Min Chul Shin, Yuji Mizuno, Toshitaka Yamaga, Megumi Maeda, Masahito Wakita, Kiyomitsu Shoudai, Kiku Nonaka
Publikováno v:
Brain Research Bulletin. 99:19-26
Atrial and brain natriuretic peptides (ANP and BNP) exist in the central nervous system and modulate neuronal function, although the locus of actions and physiological mechanisms are still unclear. In the present study we used rat spinal sacral dorsa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504e8d18e49970da14ace935cc78c76c
https://doi.org/10.1016/j.brainresbull.2013.09.003
https://doi.org/10.1016/j.brainresbull.2013.09.003
Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal
Publikováno v:
Brain Research Bulletin. 93:39-46
Neurosteroids such as allopregnanolone (Allo) are widely distributed in the brain and may modulate neuronal excitability under physiological or pathological states. Allo modulates GABAA receptor responses, and in this study we investigated the functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9954de27772576c908fa81ff5b56996
https://doi.org/10.1016/j.brainresbull.2012.11.002
https://doi.org/10.1016/j.brainresbull.2012.11.002
Autor:
Yasushi Torii, Shunji Kozaki, Norio Akaike, Min Chul Shin, Ryuji Kaji, Tetsuhiro Harakawa, Keiko Kato, Masahito Wakita, Akihiro Ginnaga
Publikováno v:
The Journal of Physiology. 591:1031-1043
Key points • Botulinum toxin A (BoNT/A) blocks synaptic transmission via the cleavage of SNAP-25. Axonal transport of BoNT/A (A1 type botulinum toxin (A1LL) and A2 type botulinum toxin (A2NTX)) from periphery to the CNS has been described in trigem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f20826b102cbb58c401848fae49f1d8
https://doi.org/10.1113/jphysiol.2012.242131
https://doi.org/10.1113/jphysiol.2012.242131