Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Masahito Kuramochi"'
Autor:
Takashi Kurashige, Masahito Kuramochi, Ryosuke Ohsawa, Yui Yamashita, Go Shioi, Hiroyuki Morino, Masaki Kamada, Takashi Ayaki, Hidefumi Ito, Yusuke Sotomaru, Hirofumi Maruyama, Hideshi Kawakami
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105215- (2021)
We previously showed that optineurin (OPTN) mutations lead to the development of amyotrophic lateral sclerosis. The association between OPTN mutations and the pathogenesis of amyotrophic lateral sclerosis remains unclear. To investigate the mechanism
Externí odkaz:
https://doaj.org/article/190dffdfc2224b6d86b31a6626a887da
Autor:
Masaki Kamada, Takashi Ayaki, Hiroyuki Morino, Ryosuke Ohsawa, Yui Yamashita, Go Shioi, Yusuke Sotomaru, Hirofumi Maruyama, Masahito Kuramochi, Hideshi Kawakami, Takashi Kurashige, Hidefumi Ito
Publikováno v:
Neurobiology of Disease, Vol 148, Iss, Pp 105215-(2021)
We previously showed that optineurin (OPTN) mutations lead to the development of amyotrophic lateral sclerosis. The association between OPTN mutations and the pathogenesis of amyotrophic lateral sclerosis remains unclear. To investigate the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4296b4babe3f285191b0c5331afee5ac
http://www.sciencedirect.com/science/article/pii/S0969996120304903
http://www.sciencedirect.com/science/article/pii/S0969996120304903
Autor:
Marta Newby, Alan Martin, Yukiko Matsuda, Hirofumi Maruyama, Mary Claire King, Tom Walsh, Hiroyuki Morino, Keiko Hiraki-Kamon, Sarah B. Pierce, Hideshi Kawakami, Rachel E. Klevit, Ming K. Lee, Masahito Kuramochi, Ryosuke Ohsawa
Publikováno v:
Neurology. 83:2054-2061
Objective: To identify the genetic cause in 2 families of progressive ataxia, axonal neuropathy, hyporeflexia, and abnormal eye movements, accompanied by progressive hearing loss and ovarian dysgenesis, with a clinical diagnosis of Perrault syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fead8d2877ee1e6280207d4f6774c3f8
https://doi.org/10.1212/wnl.0000000000001036
https://doi.org/10.1212/wnl.0000000000001036
Autor:
Ryoji Fukabori, Kazuto Kobayashi, Motokazu Uchigashima, Yuji Tsutsui, Masahiko Watanabe, Shigeki Kato, Kenta Kobayashi, Kana Okada, Masahito Kuramochi
Publikováno v:
The Journal of Neuroscience. 31:17169-17179
The dorsal striatum receives converging excitatory inputs from diverse brain regions, including the cerebral cortex and the intralaminar/midline thalamic nuclei, and mediates learning processes contributing to instrumental motor actions. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7fb9b107d1a590ccd5b4bdde8f2746
https://doi.org/10.1523/jneurosci.4005-11.2011
https://doi.org/10.1523/jneurosci.4005-11.2011
Publikováno v:
Brain Research. 1150:69-73
Anatomical evidence suggests that rat CA1 hippocampal afferents collaterally innervate excitatory projecting pyramidal neurons and inhibitory interneurons, creating a disynaptic, feed-forward inhibition microcircuit in the medial prefrontal cortex (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81863e504321134588e7225382206738
https://doi.org/10.1016/j.brainres.2007.02.063
https://doi.org/10.1016/j.brainres.2007.02.063
Autor:
Yuishin Izumi, Ryosuke Miyamoto, Hirofumi Maruyama, Masahito Kuramochi, Hidemi Kurihara, Hideshi Kawakami, Takashi Kurashige, Ryoichi Yagi, Noriyoshi Mizuno, Hiroyuki Morino
Publikováno v:
Neurobiology of aging. 35(7)
Alzheimer's disease (AD) is the most common form of dementia. To date, several genes have been identified as the cause of AD, including PSEN1, PSEN2, and APP. The association between APOE and late-onset AD has also been reported. We here used a bench
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b13d344cb5b37fc8e06828a55f2fba5
https://pubmed.ncbi.nlm.nih.gov/24559647
https://pubmed.ncbi.nlm.nih.gov/24559647
Autor:
Masahito Kuramochi, Masahiko Takada, Kenji Takasumi, Kazuhiro Ikenaka, Takashi Shimada, Daisuke Takahara, Kazuto Kobayashi, Kenta Kobayashi, Ken-ichi Inoue, Shigeki Kato, Seiji Hitoshi
Publikováno v:
Human gene therapy. 22(12)
The lentiviral vector system is used extensively in gene therapy trials for various neurological and neurodegenerative disorders. The vector system permits efficient and sustained gene expression in many cell types through integration of the transgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd94994114a5267daee27f9f25785c98
https://pubmed.ncbi.nlm.nih.gov/21806473
https://pubmed.ncbi.nlm.nih.gov/21806473
Autor:
Ken-ichi Inoue, Masahito Kuramochi, Shigeki Kato, Kenta Kobayashi, Masahiko Takada, Kazuto Kobayashi
Publikováno v:
Viral Gene Therapy
Gene transfer vectors derived from neurotropic viruses provide a powerful tool for gene therapy of a variety of neurological diseases. The lentiviral vector system permits the efficient transfer of genes into non-dividing cells in the central nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8217e0258b8393a5afd27d7791415d2e
https://doi.org/10.5772/21992
https://doi.org/10.5772/21992
Autor:
Takashi Shimada, Tomoaki Okada, Ken-ichi Inoue, Kinjiro Morimoto, Kenta Kobayashi, Kazuto Kobayashi, Hiroyuki Yaginuma, Masahiko Takada, Shigeki Kato, Masahito Kuramochi
Publikováno v:
Human gene therapy. 22(2)
The lentiviral vector system based on human immunodeficiency virus type 1 (HIV-1) is used extensively in gene therapy trials of neurological and neurodegenerative diseases. Retrograde axonal transport of viral vectors offers a great advantage to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0f7cef0bcb6c01d4f4c66ff968964a
https://pubmed.ncbi.nlm.nih.gov/20954846
https://pubmed.ncbi.nlm.nih.gov/20954846
Publikováno v:
Neuroreport. 21(1)
We examined the effect of long-term potentiation (LTP) on paired-pulse responses across varied stimulus intensities and interstimulus intervals (ISIs), at ascending synapses from the intermediate and ventral hippocampus to the medial prefrontal corte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29c4b0bcac1f3c1957be33e27523565
https://pubmed.ncbi.nlm.nih.gov/19996810
https://pubmed.ncbi.nlm.nih.gov/19996810