Výsledky vyhledávání - "Masahito Kano"

Mutations identified in the human multidrug resistance P-glycoprotein 3 (ABCB4) gene in patients with primary hepatolithiasis

Autor: Naomi Tanaka, Koji Oda, Junichi Shoda, Ryo Sumazaki, Yuji Nimura, Masahito Kano

Publikováno v: Hepatology Research. 29:160-166

Primary hepatolithiasis (HL), highly prevalent in the Far East, including Japan, is characterized clinically by chronic proliferative cholangitis with frequent recurrences. In HL patients, hepatic hyposecretion of phospholipid due to decreased multid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2e586d4d9552555df15ca5da195977
https://doi.org/10.1016/j.hepres.2004.03.002

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Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver

Autor: Hidetaka Akita, Masahiro Yamamoto, Hiroshi Suzuki, Masahito Kano, Tadashi Ikegami, Junichi Shoda, Hirotoshi Utsunomiya, Yuichi Sugiyama, Tetsuo Miura, Koji Oda, Naomi Tanaka, Kousei Ito

Publikováno v: Hepatology. 39:167-178

Inchin-ko-to (ICKT), an herbal medicine, and its ingredients exert potent choleretic effects by a "bile acid-independent" mechanism. The current study was designed to determine whether ICKT or its ingredients potentiate multidrug resistance-associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e27134d6ba6efcd39cd02f6b9deeb55
https://doi.org/10.1002/hep.20003

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Increased expression of gallbladder cholecystokinin: A receptor in prairie dogs fed a high-cholesterol diet and its dissociation with decreased contractility in response to cholecystokinin

Autor: Yasushi Matsuzaki, Masakazu Kobayashi, Masahito Kano, Junichi Shoda, Masato Abei, Naomi Tanaka, Susumu Satoh

Publikováno v: Journal of Laboratory and Clinical Medicine. 139:285-294

A series of our studies have shown that formation of cholesterol-supersaturated bile in patients with cholesterol gallstone disease is causatively related to decreased gallbladder contractility and mucin hypersecretion by the gallbladder. Supersatura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736618129304ce01528ec068af06865c
https://doi.org/10.1067/mlc.2002.122863

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The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function

Autor: Koji Oda, Hiroshi Suzuki, Masahito Kano, Siegfried Stengelin, Junichi Kamiya, Takeski Todoroki, Yasushi Matsuzaki, Yuichi Sugiyama, Junichi Shoda, Werner Kramer, Hiroshi Miyazaki, Naomi Tanaka, Yuji Nimura

Publikováno v: The American Journal of Gastroenterology. 96:3368-3378

Percutaneous transhepatic biliary drainage (PTBD) has been believed to reduce hyperbilirubinemia in patients with obstructive cholestasis and to lessen liver injury through bile acid retention. The efficacy may be closely related to the capability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28971a37ff78826b069f0218920af6bc
https://doi.org/10.1111/j.1572-0241.2001.05339.x

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Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi

Autor: Koji Oda, Junichi Kamiya, Yuichi Sugiyama, Junichi Shoda, Hiroshi Miyazaki, Li Feng, Masahito Kano, Yasushi Matsuzaki, David E. Cohen, Yuji Nimura, Kosei Ito, Naomi Tanaka, Hiroshi Suzuki

Publikováno v: Hepatology. 33:1194-1205

Intrahepatic calculi, highly prevalent in the Far East, including Japan, are characterized clinically by chronic proliferative cholangitis with frequent stone recurrences. Intrahepatic calculi consist of 2 groups, i.e., brown pigment stones, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f08462aa35654c44a106ff4ffcdee52
https://doi.org/10.1053/jhep.2001.23936

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The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue

Autor: Yasushi Matsuzaki, Naomi Tanaka, Junichi Shoda, Masahito Kano, Norio Hirabayashi, Tadashi Ikegami

Publikováno v: Cancer Letters. 134:129-139

Great interest has been focused on the chemoprevention of colonic carcinogenesis by oral administration of ursodeoxycholic acid (UDCA) because its administration reportedly reduces the incidence of colon cancer in animal experiments. To elucidate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d283ce7dc7ee74e9bc9deaecd809d0a0
https://doi.org/10.1016/s0304-3835(98)00248-1

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Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones

Autor: Tetsuya Ueda, Junichi Shoda, Yasushi Kawauchi, Toru Asano, Tatsuro Irimura, Naomi Tanaka, Yasushi Matsuzaki, Tetsuya Urasaki, Masahito Kano, Ryu Iwasaki

Publikováno v: Hepatology. 28:302-313

Group IIA phospholipase A2 (PLA2), a secretory low-molecular-weight PLA2, may play a critical role in the process of gallbladder mucosal inflammation in multiple cholesterol stones, which in turn may produce biliary pronucleating proteins as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b518b1efac298e76ec23e3b275ec016e
https://doi.org/10.1002/hep.510280204

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Increased biliary group II phospholipase A2 and altered gallbladder bile in patients with multiple cholesterol stones

Autor: Susumu Satoh, Naomi Tanaka, Tetsuya Ueda, Masahito Kano, Kenji Matsuura, Junichi Shoda, Tadashi Ikegami, Yasushi Matsuzaki

Publikováno v: Gastroenterology. 112:2036-2047

Multiple cholesterol stones are associated with more biliary complications and show more rapid cholesterol nucleation than solitary stones. Group II phospholipase A2 (PLA2-II) may play a critical role in the process of mucosal inflammation, which in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b0d4d90f1b978929459aab255c9d34
https://doi.org/10.1053/gast.1997.v112.pm9178697

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Simultaneous determination of plasma mevalonate and 7 ?-hydroxy-4-cholesten-3-one levels in hyperlipoproteinemia: Convenient indices for estimating hepatic defects of cholesterol and bile acid syntheses and biliary cholesterol supersaturation

Autor: Tadashi Ikegami, Toshiaki Osuga, Junichi Shoda, J. Miyamoto, Yasushi Matsuzaki, Masahito Kano, Hiroshi Miyazaki, Naomi Tanaka

Publikováno v: Hepatology. 25:18-26

The high prevalence of cholesterol gallstone disease in hypertriglyceridemic patients may be associated with frequent metabolic defects in cholesterol and bile acid syntheses and in the concomitant formation of bile supersaturated with cholesterol. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09248bbb5db3d2691b3352146899954c
https://doi.org/10.1002/hep.510250105

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Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers

Autor: Masahito Kano, Katsutoshi Yoshizato, Hiroshi Suzuki, Hiroshi Takahashi, Koji Oda, Hirotoshi Utsunomiya, Ayaka Watanabe, Ken Itoh, Masayuki Yamamoto, Kosuke Okada, Masahiro Yamamoto, Kimi Sato, Nobuhiro Ohtake, Junichi Shoda, Tsuyoshi Yokoi, Sachiko Suzuki, Tetsuro Ishii, Yuichi Sugiyama

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 292(5)

Inchinkoto (ICKT), a herbal medicine, has been recognized in Japan and China as a “magic bullet” for jaundice. To explore potent therapeutic agents for cholestasis, the effects of ICKT or its ingredients on multidrug resistance-associated protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8772d120a4b8969e37c030b3115cc3d6
https://pubmed.ncbi.nlm.nih.gov/17038627

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