Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Masahiro Shimamura"'
Publikováno v:
Renal Replacement Therapy, Vol 3, Iss 1, Pp 1-10 (2017)
Abstract Background Nalfurafine hydrochloride (“nalfurafine”), the world’s first selective oral κ-receptor agonist for improving pruritus, is approved in Japan for the treatment of pruritus resistant to existing treatments in hemodialysis (HD)
Externí odkaz:
https://doaj.org/article/85f17c64af324cc986cfe78912f740ac
Autor:
Takashi SHINAGAWA, Koichi UEKI, Masahiro SHIMAMURA, Yutaka SHIBATA, Naomi TAKEMURA, Yoshiaki SUGIYAMA
Publikováno v:
Japanese Journal of Sports Dentistry / Supotsu Shigaku; Feb2023, Vol. 26 Issue 2, p19-22, 4p
Publikováno v:
Renal Replacement Therapy, Vol 3, Iss 1, Pp 1-10 (2017)
Background Nalfurafine hydrochloride (“nalfurafine”), the world’s first selective oral κ-receptor agonist for improving pruritus, is approved in Japan for the treatment of pruritus resistant to existing treatments in hemodialysis (HD) or chron
Autor:
Kazunari Kimoto, Kyoutarou Hada, Masayasu Tsujimura, Takeyoshi Aoki, Tomoyasu Mizutani, Takashi Shinagawa, Koichi Ueki, Masahiro Shimamura, Yoshiaki Sugiyama
Publikováno v:
International Journal of Sports Dentistry; 11/10/2017, Vol. 10 Issue 1, p32-39, 8p
Autor:
Aiji Miyashita, Ikumi Nakajo, Hajimu Kurumatani, Jun Miyakawa, Masanao Isono, Keiyu Oshida, Kiyonobu Okada, Yohei Miyamoto, Masaaki Doi, Fumihiko Ushigome, Keishi Oikawa, Masahiro Shimamura, Yoshitaka Mori
Publikováno v:
The Journal of Clinical Pharmacology. 57:524-535
The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS-314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS-314d were meas
Autor:
Masahiro, Shimamura, Jun, Miyakawa, Masaaki, Doi, Kiyonobu, Okada, Hajimu, Kurumatani, Yoshitaka, Mori, Keiyu, Oshida, Ikumi, Nakajo, Keishi, Oikawa, Fumihiko, Ushigome, Aiji, Miyashita, Masanao, Isono, Yohei, Miyamoto
Publikováno v:
Journal of clinical pharmacology. 57(4)
The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS-314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS-314d were meas
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 42(1)
Beraprost sodium (BPS) is a chemically stable and orally active prostacyclin analog that is used in the treatment of chronic arterial occlusive disease since 1992 and primary pulmonary hypertension since 1999 in Japan. Multiple-drug therapy is common
Autor:
Hiroki Kumagai, Yutaka Nishimura, Chifumi Inada, Hideaki Fujii, Aiko Nitta, Shiho Satoh, Junko Nakaki, Tomofumi Ohyama, Mikiya Satoh, Hideki Kozono, Masahiro Shimamura, Satoshi Sakami, Tominaga Fukazawa, Hideki Kawai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5435-5438
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino-N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzoth
Autor:
Yoshinori Yajima, Tsutomu Suzuki, Chiharu Kubota, Michiko Narita, Masahiro Shimamura, Minoru Narita
Publikováno v:
Brain Research. 992:288-293
In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast,
Autor:
M. Shiokawa, Michiko Narita, T. Inoue, Satoshi Imai, Masahiro Shimamura, Yoshinori Yajima, Tsutomu Suzuki, Tomoe Takagi, Masami Suzuki, Chiharu Kubota
Publikováno v:
Neuroscience. 152(2)
The present study investigated whether the endogenous pro-inflammatory cytokines [interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha)]-dependent expression of cyclooxygenase-2 (COX-2) mRNA within the spinal cord could be involved in th