Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Masahiro Segawa"'
Autor:
Manabu Fuchikami, Shigeru Morinobu, Masahiro Segawa, Yasumasa Okamoto, Shigeto Yamawaki, Norio Ozaki, Takeshi Inoue, Ichiro Kusumi, Tsukasa Koyama, Kounosuke Tsuchiyama, Takeshi Terao
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23881 (2011)
Major depression, because of its recurring and life-threatening nature, is one of the top 10 diseases for global disease burden. Major depression is still diagnosed on the basis of clinical symptoms in patients. The search for specific biological mar
Externí odkaz:
https://doaj.org/article/17bed39f3e224b739727bc1ed01d1e20
Publikováno v:
Journal of Toxicological Sciences. 2019, Vol. 44 Issue 11, p811-820. 10p.
Publikováno v:
The Journal of Toxicological Sciences. 44:811-820
Troglitazone, the first peroxisome proliferator-associated receptor γ agonist developed as an antidiabetic drug, was withdrawn from the market due to idiosyncratic severe liver toxicity. One proposed mechanism by which troglitazone causes liver inju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9b1c70c55d5e952ba59157a18dd510
https://doi.org/10.2131/jts.44.811
https://doi.org/10.2131/jts.44.811
Publikováno v:
The Journal of Toxicological Sciences. 44:833-843
Drug-induced liver injury is not readily detectable using conventional animal studies during pre-clinical drug development. To address this problem, other researchers have proposed the use of co-administration of lipopolysaccharide (LPS), an endotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1470ae55d3d2dbcc4405f6f4c8e1a3e
https://doi.org/10.2131/jts.44.833
https://doi.org/10.2131/jts.44.833
Publikováno v:
Journal of Toxicological Sciences. 2018, Vol. 43 Issue 5, p339-351. 13p.
Publikováno v:
The Journal of toxicological sciences. 44(11)
Troglitazone, the first peroxisome proliferator-associated receptor γ agonist developed as an antidiabetic drug, was withdrawn from the market due to idiosyncratic severe liver toxicity. One proposed mechanism by which troglitazone causes liver inju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b48c4a91ba092b3d42a8480ab0fab19
https://pubmed.ncbi.nlm.nih.gov/31708537
https://pubmed.ncbi.nlm.nih.gov/31708537
Autor:
Chihiro Kaneko, Masaki Kobayashi, Takashi Tsujimoto, Jiro Ogura, Hiroaki Yamaguchi, Masahiro Segawa, Shunichi Sasaki, Kaori Kuwayama, Takahiro Koizumi, Ken Iseki, Keisuke Yabe
Publikováno v:
Biopharmaceutics & Drug Disposition. 35:173-182
Quercetin-3-rhamnoglucoside (rutin) has a wide spectrum of biochemical and pharmacological activities. Rutin is absorbed mainly in its unmetabolized form. Organic anion transporting polypeptide (OATP) 2B1 is a major uptake transporter in the intestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a99d0c5d583a582c5cd856c218c0f36
https://doi.org/10.1002/bdd.1882
https://doi.org/10.1002/bdd.1882
Autor:
Manabu Fuchikami, Shigeru Morinobu, Shigeto Yamawaki, Yosuke Yamawaki, Tomoya Matsumoto, Masahiro Segawa
Publikováno v:
The World Journal of Biological Psychiatry. 13:458-467
Epigenetic mechanisms, such as changes in gene expression resulting from chromatin remodeling through histone acetylation, have been implicated in the pathophysiology of depression. However, the antidepressant-like effect of the histone deacetylase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9406bc794144752de49111fc7a97447f
https://doi.org/10.3109/15622975.2011.585663
https://doi.org/10.3109/15622975.2011.585663
Publikováno v:
Toxicology Letters. 295:S242
Troglitazone, a member of the thiazolidinedione class of antidiabetic drugs, was withdrawn from the market because it causes severe liver injury. One of the mechanisms for this adverse effect is thought to be mitochondrial toxicity. To investigate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa965d1c70a59066b8edfa4095578bf
https://doi.org/10.1016/j.toxlet.2018.06.1002
https://doi.org/10.1016/j.toxlet.2018.06.1002
Autor:
Kounosuke Tsuchiyama, Masaru Mimura, Yasumasa Okamoto, Yosuke Kokubo, Takeshi Terao, Shigeru Morinobu, Tsutomu Kataoka, Shigeto Yamawaki, Takeshi Inoue, Manabu Fuchikami, Satoshi Okada, Kana Yokomaku, Masahiro Segawa, Ichiro Kusumi, Tsukasa Koyama
Publikováno v:
Journal of psychiatric research. 53
We examined the utility of DNA methylation profiles at the CpG island of SLC6A4 (DMS) as a diagnostic biomarker for major depression (MD). In addition, the relationship between DMS and the serotonin transporter gene-linked polymorphic region (5-HTTLP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbeba36677e8bbf987ce6df77a83687
https://pubmed.ncbi.nlm.nih.gov/24657235
https://pubmed.ncbi.nlm.nih.gov/24657235