Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Masahiro NOBUHARA"'
Autor:
Masahiro Nobuhara, Hiromi Ogino, Hideaki Morishita, Masayoshi Namba, Norio Nakamura, Toshinori Kanamori, Toru Yamakawa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1090:216-222
A high-level and stable expression system of human tissue-type plasminogen activator (t-PA) was accomplished in human cells by selecting a promoter and a host cell line. First, we have constructed two types of t-PA expression plasmids containing 3 kb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79f9fb0bc2447e8f039d0fab5ac6723
https://doi.org/10.1016/0167-4781(91)90104-t
https://doi.org/10.1016/0167-4781(91)90104-t
Autor:
Masahiko Ohta, Hiroyuki Kawano, Norio Nakamura, Toshinori Kanamori, Masahiro Nobuhara, Kenzo Tanaka, Katsuo Sueishi, Isao Tanaka, Meroni Imai, Yoshikazu Ashida, Yasuhito Tanaka
Publikováno v:
Japanese Journal of Thrombosis and Hemostasis. 2:12-20
The effect of recombinant human single-chain tissue-type plasminogen activator (MMR701) on the patency rate of infarct-related coronary arteries was investigated in anesthetized dogs with coronary thrombi induced by inserting a copper coil into the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e430220bba2f581768d7cb56c556cbf
https://doi.org/10.2491/jjsth.2.12
https://doi.org/10.2491/jjsth.2.12
Autor:
Syuichi Shiraki, Hajime Nawata, Hideyuki Masuko, Hiroshi Sato, Akinori Tatematsu, Kazuyuki Nakayama, Fumio Umeda, Masahiro Nobuhara, Naoki Nakashima, Toshinori Kanamori
Publikováno v:
The Journal of Japan Atherosclerosis Society. 19:55-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c84ed404500aecfd12ad37ed3eea0f8a
https://doi.org/10.5551/jat1973.19.1_55
https://doi.org/10.5551/jat1973.19.1_55
Autor:
Rie Sameshima-Aruga, Yasukazu Nagase, Tomokazu Matsusue, Masahiro Nobuhara, Toru Yamakawa, Atsushi Nii, Sadatoshi Koyama, Jiro Hirose, Reiko Horisawa-Nakano, Masaaki Naotsuka, Mitsuko Isaji, Toshihisa Miura, Hideaki Morishita, Ryo Tanaka, Takeshi Kusuyama, Toshinori Kanamori
Publikováno v:
Thrombosis research. 73(3-4)
Urinary trypsin inhibitor is a glycoprotein with a structure in which two Kunitz-type inhibitory domains are linked in a row. We isolated two genes encoding the 70 amino acid sequence from the 78th amino acid (Thr) to the C-terminal and the 68 amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c63bbdc3e9d551e2cf1b2cf734e9121
https://pubmed.ncbi.nlm.nih.gov/8191413
https://pubmed.ncbi.nlm.nih.gov/8191413
Autor:
Yoshifumi Horisawa, Masahiro Nobuhara, Kazuharu Kato, Masashi Kurimoto, Meroni Imai, Yasuo Tanaka, Norio Nakamura, Tetsuya Asami, Yoshitaka Hosaka, Toshinori Kanamori, Yoshikazu Ashida
Publikováno v:
Japanese Journal of Cancer Research : Gann
We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n‐TNF) isolated from a culture of human leukemic B cell line (BALL‐1), especially its action as an immunomodulator, and found that the in vivo antitumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a89e12999371affc84a6c853c3540d
https://doi.org/10.1111/j.1349-7006.1989.tb01648.x
https://doi.org/10.1111/j.1349-7006.1989.tb01648.x
Publikováno v:
Cancer Letters. 20:131-138
Experiments were performed to ascertain whether the antitumor effect of various anticancer drugs might be enhanced by interferon, using cultures of HeLa cells originating from a human carcinoma of the uterine cervix. The effects of drugs were assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe520b0915a78fd5b6f3721ecf201c50
https://doi.org/10.1016/0304-3835(83)90041-1
https://doi.org/10.1016/0304-3835(83)90041-1
Autor:
Junichi Tohyama, Atsushi Nn, Toshinori Kanamori, Masahiro Nobuhara, Hiromi Ogino, Yasukazu Nagase, Hideaki Morishita
Publikováno v:
Agricultural and Biological Chemistry. 52:1331-1338
This study was done to investigate the effects of modified nucleotide sequences around the initiation codon on gene expression efficiency in Escherichia coli. A human tumor necrosis factor-β-galactosidase fused gene was used to randomly modify both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a551a4a002258d8d8eaba08cc0594aa6
https://doi.org/10.1271/bbb1961.52.1331
https://doi.org/10.1271/bbb1961.52.1331
Publikováno v:
Blood & Vessel. 16:26-29
We have purified the tissue-type plasminogen activator (t-PA) produced by human melanoma cell line and have investigated its protein-chemical characteristics and fibrinolytic activity. Either one-chain or two-chain t-PA was obtained in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d453b629dac586c4f9e3243ae0e259
https://doi.org/10.2491/jjsth1970.16.26
https://doi.org/10.2491/jjsth1970.16.26
Publikováno v:
Blood & Vessel. 18:278-281
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f37bf3a5f49199bf5057fab4c2541601
https://doi.org/10.2491/jjsth1970.18.278
https://doi.org/10.2491/jjsth1970.18.278
Publikováno v:
Cancer Letters. 22:135-141
The antitumor effect of 5-fluorouracil (5-FU) was significantly enhanced by inosiplex which has been developed as a drug possessing antiviral activity. The enhancement of antitumor effect of 5-FU was demonstrated by experiments both in vitro and in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15c315f6d2cdd6b4c8fdf6199f95e70
https://doi.org/10.1016/0304-3835(84)90110-1
https://doi.org/10.1016/0304-3835(84)90110-1