Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Masahiro NAGAI"'
Autor:
Koichi Tanaka, Mohammed E. Choudhury, Satoshi Kikuchi, Ikuko Takeda, Kensuke Umakoshi, Noriyuki Miyaue, Kanta Mikami, Ayane Takenaga, Harumichi Yagi, Rintaro Shinabe, Hironori Matsumoto, Hajime Yano, Masahiro Nagai, Jun Takeba, Junya Tanaka
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109587- (2024)
Summary: In this study, a murine sepsis model was developed using the cecum ligation and puncture (CLP) technique. The expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) in the brain increase
Externí odkaz:
https://doaj.org/article/7d116aa1574c4a7fb90662063b090b33
Publikováno v:
Neurology International, Vol 15, Iss 3, Pp 1044-1051 (2023)
Serum growth differentiation factor 15 (GDF-15) levels are elevated in patients with Parkinson’s disease (PD) and may help differentiate these patients from healthy individuals. We aimed to clarify whether serum GDF-15 levels can help differentiate
Externí odkaz:
https://doaj.org/article/f7780726801849b081d2f39a0e72d69e
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 9, Iss , Pp 100227- (2023)
Introduction: Constipation is one of the most frequent non-motor symptoms of Parkinson's disease (PD), and magnesium oxide (MgO) is a frequently used laxative. This study aimed to investigate the effect of concomitant use of MgO on the pharmacokineti
Externí odkaz:
https://doaj.org/article/a8e48baccc5a4afe8770c1366c660ae8
Autor:
Masahiro Ando, Yujiro Higuchi, Junhui H. Yuan, Akiko Yoshimura, Shuntaro Higashi, Mika Takeuchi, Takahiro Hobara, Fumikazu Kojima, Yutaka Noguchi, Jun Takei, Yu Hiramatsu, Satoshi Nozuma, Yusuke Sakiyama, Akihiro Hashiguchi, Eiji Matsuura, Yuji Okamoto, Masahiro Nagai, Hiroshi Takashima
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The recessive intronic pentanucleotide repeat AAGGG expansion of replication factor complex subunit 1 (RFC1) is associated with cerebellar ataxia, sensory neuropathy, and vestibular areflexia syndrome. And the clinical spectrum has been continuously
Externí odkaz:
https://doaj.org/article/9c12a514189a414aa34891f2c6ce23a7
Publikováno v:
Brain and Behavior, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Introduction Levodopa and carbidopa are reported to be degraded by magnesium oxide (MgO), which is often used as a laxative for patients with Parkinson's disease (PD). Ascorbic acid (AsA) can stabilize levodopa and carbidopa solutions; howev
Externí odkaz:
https://doaj.org/article/4fc2396e02d543e89caac98487aaece0
Autor:
Nobutaka Hattori, Atsushi Takeda, Yuki Hanya, Tadayuki Kitagawa, Masaki Arai, Yoshihiko Furusawa, Hideki Mochizuki, Masahiro Nagai, Ryosuke Takahashi
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Background Identifying the factors that influence health-related quality of life (HRQoL) is of great scientific interest, but a potential causal relationship between treatment and HRQoL has yet to be fully elucidated. Japanese patients reported bette
Externí odkaz:
https://doaj.org/article/2c6362786420438bbc73b3c4075c4161
Autor:
Mohammed E. Choudhury, Saya Ozaki, Noriyuki Miyaue, Taisei Matsuura, Kanta Mikami, Afsana Islam, Madoka Kubo, Rina Ando, Hajime Yano, Takeharu Kunieda, Masahiro Nagai, Junya Tanaka
Publikováno v:
Brain Sciences, Vol 13, Iss 1, p 55 (2022)
Activated microglia potentially cause neurodegeneration in Parkinson’s disease (PD). Matrix metalloproteinase (MMP)-9 plays a crucial role in the pathogenesis of PD, but the modulator of microglial release of MMP-9 remains obscure. Given the modula
Externí odkaz:
https://doaj.org/article/39b91d4a0d7b4387b7e6242fa12d6833
Pharmacokinetics and safety/efficacy of levodopa pro-drug ONO-2160/carbidopa for Parkinson's disease
Autor:
Masahiro Nomoto, Masahiro Nagai, Noriko Nishikawa, Rina Ando, Yoshifumi Kagamiishi, Koji Yano, Shigeto Saito, Atsushi Takeda
Publikováno v:
eNeurologicalSci, Vol 13, Iss , Pp 8-13 (2018)
We conducted a phase I study investigating the efficacy, safety, and tolerability of ONO-2160, a newly developed levodopa pro-drug, and carbidopa compared with levodopa and carbidopa to stabilize levodopa plasma concentration fluctuations in Japanese
Externí odkaz:
https://doaj.org/article/91eb2501e202496dace147da54a25d4f
Autor:
Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Kimiko Izumo, Nobuaki Nakano, Eiji Matsuura, Mineki Saito, Masahiro Nagai, Masahisa Horiuchi, Atae Utsunomiya, Hiroshi Takashima, Ryuji Kubota, Shuji Izumo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008361 (2020)
Human T-cell leukemia virus type 1 (HTLV-1) causes incurable adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Patients with HAM/TSP have increased levels of HTLV-1-infected cells compared with asymptomati
Externí odkaz:
https://doaj.org/article/45b26dbcd2734f2992430d4f06be1fac
Publikováno v:
Brain Sciences, Vol 12, Iss 2, p 268 (2022)
Mitochondrial dysfunction and exacerbated neuroinflammation are critical factors in the pathogenesis of both familial and non-familial forms of Parkinson’s disease (PD). This study aims to understand the possible ameliorative effects of zonisamide
Externí odkaz:
https://doaj.org/article/88fef714f3b243e9afedac67ec525dfb