Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Masahiro Mizota"'
Synthesis and diuretic activity of 2,3-dihydro-4(1H)-quinolinone 4-oxime-O-sulfonic acid derivatives
Autor:
Kikuo Ohtomo, Hidemitsu Nishida, Masahiro Mizota, Yoshiaki Yamashita, Kazuo Kato, Kazumi Nishijima, Naofumi Sato, Tomoaki Shinkawa, Sotaro Miyano, Yoshiaki Onuki
Publikováno v:
European Journal of Medicinal Chemistry. 33:267-277
The diuretic activity of 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime 1 (M12285) was previously shown to derive from a 6-chloro-2,3-dihydro-1-propionyl-4(1H)-quinolinone 4-oxime-O-sulfonic acid salt as a rat metabolite. Thus, in the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df6f9d5c6927c3be353d893f254f9715
https://doi.org/10.1016/s0223-5234(98)80061-5
https://doi.org/10.1016/s0223-5234(98)80061-5
Publikováno v:
Nephron. 76:300-306
The cytoprotective effect of ulinastatin was studied in LLC-PK1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release of lactate dehydrogenase and a decrease in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::232610d4c21bfb2102c6f5ebd649983b
https://doi.org/10.1159/000190195
https://doi.org/10.1159/000190195
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 433:9-15
We investigated the uptake of human urinary trypsin inhibitor (UTI) by the kidney epithelial cells, LLC-PK1. Indirect immunogold techniques with an electron microscope demonstrated the localization of UTI within the cells after an incubation during w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf047f9223edc3b17b9842a4696e07e
https://doi.org/10.1007/s004240050242
https://doi.org/10.1007/s004240050242
Autor:
Nobuya Murakami, Masahiro Mizota, Katsuaki Kato, Mitsuhiro Takeda, Koji Hashimoto, Keiichi Ida, Yuji Nagao
Publikováno v:
Biochemical Pharmacology. 52:1529-1535
The effects of BRL35135A ((R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2 -(3-chlorophenyl)ethylamino]propyl]-phenoxyacetate hydrobromide), a beta 3-adrenoceptor agonist, on visceral and subcutaneous fat weight and metabolic disorders were studied in genetica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d59871adcc5879841117f71f46ac61
https://doi.org/10.1016/s0006-2952(96)00552-7
https://doi.org/10.1016/s0006-2952(96)00552-7
Autor:
Jun Okuda, Nobuya Murakami, Masahiro Mizota, Kazuwa Nakao, Ichitomo Miwa, Koji Hashimoto, Katsuaki Kato, Hideshi Kuzuya, Masahiko Ohta, Hiroo Imura, Gen Inoue
Publikováno v:
European Journal of Pharmacology. 304:129-134
Improvement of metabolic disorders by M16209 (1-(3-bromobenzofuran-2-ylsulfonyl)hydantoin), an antidiabetic agent, was studied in genetically obese Zucker fa/fa rats and C57BL/6J ob/ob mice. In fa/fa rats oral administration of M16209 (30 and 100 mg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2048c3f7b6e5c79282eddd8038e2f4a0
https://doi.org/10.1016/0014-2999(96)00121-5
https://doi.org/10.1016/0014-2999(96)00121-5
Autor:
Masanori Nakakuki, Tomoaki Shinkawa, Masaaki Ishibashi, Mitsutoshi Watanabe, Masahiro Mizota, Fumiaki Yamasaki
Publikováno v:
Nephron. 74:158-167
The development of azotemia after cisplatin injection in mice was inhibited by ulinastatin treatment in a dose-dependent manner. Reduction in creatinine clearance and elevation in fractional excretion of sodium in mice receiving cisplatin was amelior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08f3731406aa15508301d5074a8ba37
https://doi.org/10.1159/000189296
https://doi.org/10.1159/000189296
Autor:
Jun Okuda, Tatsuto Notsu, Masahiko Ohta, Ichitomo Miwa, Nobuya Murakami, Katsuaki Kato, Masahiro Mizota, Kazuo Nakayama
Publikováno v:
European Journal of Pharmacology. 276:85-91
We investigated the stimulatory effect of M16209 (1-(3-bromobenzo[b]furan-2-yl-sulfonyl)hydantoin), a novel aldose reductase inhibitor, on insulin secretion using isolated, perfused pancreases of rats. In the pancreases from normal rats, M16209 (100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492f1a1399f96416c3b1db4d08ee1e23
https://doi.org/10.1016/0014-2999(95)00016-e
https://doi.org/10.1016/0014-2999(95)00016-e
Antihyperglycemic effects of M16209, a novel aldose reductase inhibitor, in normal and diabetic rats
Autor:
Keiichi Ida, Masahiro Mizota, Masahiko Ohta, Jun Okuda, Nobuya Murakami, Kazuo Nakayama, Ichitomo Miwa, Katsuaki Kato
Publikováno v:
European Journal of Pharmacology. 276:77-83
The effect of a single oral administration of M16209 (1-(3-bromobenzo[ b ]furan-2-yl-sulfonyl)hydantoin), a novel aldose reductase inhibitor, on serum glucose was investigated. In normal rats, M16209 (100 mg/kg) had a weak hypoglycemic effect but mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb16ace8b714915d40d863696801a77
https://doi.org/10.1016/0014-2999(95)00015-d
https://doi.org/10.1016/0014-2999(95)00015-d
Autor:
Akio Uemura, Yutaka Kato, Naoko Tsuchiya, Masahiro Mizota, Tomoaki Shinkawa, Fumiaki Yamasaki
Publikováno v:
Japanese Journal of Pharmacology. 63:241-249
We investigated the effects of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats (SHR). M17055 was orally administered once a day for 24 consecutive days to 14-week-old male SHR. M17055 at d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa8d9e23fb5d3c7795c5f277decb03a
https://doi.org/10.1254/jjp.63.241
https://doi.org/10.1254/jjp.63.241
Autor:
Masami Sato, Yasuyuki Kunihiro, Kaoru Fukuhara, Yukio Katsuki, Masahiro Mizota, Hiroyuki Kawano, Yoshimasa Hamada
Publikováno v:
Biological and Pharmaceutical Bulletin. 16:362-367
The effects of ethyl all-cis-5,8,11,14,17-icosapentaenoate (EPA-E), highly purified ethyl ester of icosapentaenoic acid (EPA), on rabbit platelets were studied. In in vitro, highly purified EPA (62.5-3000 microM) suppressed the platelet aggregation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97feaefe07452a514c2298309865b61
https://doi.org/10.1248/bpb.16.362
https://doi.org/10.1248/bpb.16.362