Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Masahiro Marshall Nakagawa"'
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 199-205 (2018)
Inflammatory signals have been shown to play a critical role in controlling the maintenance and functions of hematopoietic stem cells (HSCs). While the significance of inflammation in hematopoiesis has begun to unfold, molecular mechanisms and player
Externí odkaz:
https://doaj.org/article/8ee26ead7a3845828b3d10f9bfbaa225
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2094-2109.e4 (2018)
Summary: Constitutive activation of the canonical NF-κB pathway has been associated with a variety of human pathologies. However, molecular mechanisms through which canonical NF-κB affects hematopoiesis remain elusive. Here, we demonstrate that der
Externí odkaz:
https://doaj.org/article/0f9120c0a883489eafb227285c8e7987
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Identifying physiological roles of specific signaling pathways that regulate hematopoietic stem cell (HSC) functions may lead to new treatment strategies and therapeutic interventions for hematologic disorders. Here, we provide genetic evidence that
Externí odkaz:
https://doaj.org/article/12cb971b1de0431c91949c17323d8df0
Autor:
Yasuhito Nannya, Magnus Tobiasson, Shinya Sato, Elsa Bernard, Shigeki Ohtake, June Takeda, Maria Creignou, Lanying Zhao, Manabu Kusakabe, Yuhei Shibata, Nobuhiko Nakamura, Mizuki Watanabe, Nobuhiro Hiramoto, Yusuke Shiozawa, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Yoshida, Nobuyuki Kakiuchi, Hideki Makishima, Masahiro Marshall Nakagawa, Kensuke Usuki, Mitsumasa Watanabe, Kazunori Imada, Hiroshi Handa, Masataka Taguchi, Toru Kiguchi, Kazuma Ohyashiki, Takayuki Ishikawa, Akifumi Takaori-Kondo, Hisashi Tsurumi, Senji Kasahara, Shigeru Chiba, Tomoki Naoe, Satoru Miyano, Elli Papaemmanuil, Yasushi Miyazaki, Eva Hellström Lindberg, Seishi Ogawa
Publikováno v:
Blood Advances.
Azacitidine is a mainstay of therapy for MDS-related diseases. The purpose of our study is to elucidate the effect of gene mutations on hematological response and overall survival (OS), particularly focusing on their post-treatment clone size. We enr
Autor:
Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia C. Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro Marshall Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Publikováno v:
Blood. 140:208-210
Autor:
Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Qi Xingxing, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa
Publikováno v:
Blood. 140:2881-2882
Background Clonal hematopoiesis (CH) in apparently healthy individuals has been drawing an increasing attention of recent years due to its implication in the risk of hematopoietic malignancies and also in cardiovascular complications. However, our kn
Autor:
Takuto Mori, Yotaro Ochi, Ayana Kon, Tetsuichi Yoshizato, Haruhiko Koseki, Manabu Nakayama, Akinori Yoda, Masahiro Marshall Nakagawa, June Takeda, Ryunosuke Saiki, Rurika Okuda, Yasunobu Nagata, Kenichi Yoshida, Masashi Sanada, Hideki Makishima, Akifumi Takaori-Kondo, Jaroslaw P. Maciejewski, Yoshiko Atsuta, Torsten Haferlach, Yasuhito Nannya, Seishi Ogawa
Publikováno v:
Blood. 140:4022-4023
Autor:
Pedro Luis Moura, Isabel Juliana F Hofman, Yasuhito Nannya, Affaf Aliouat, Teresa Mortera-Blanco, Tetsuichi Yoshizato, Ryunosuke Saiki, Masahiro Marshall Nakagawa, Ann-Charlotte Björklund, Gunilla Walldin, Indira Barbosa, Monika Jansson, Francesca Grasso, Maria Creignou, Edda Maria Elvarsdottir, Petter S Woll, Sten Eirik Waelgaard Jacobsen, Seishi Ogawa, Eva Hellström-Lindberg
Publikováno v:
Blood. 140:6898-6899
Autor:
Ayana, Kon, Satoshi, Yamazaki, Yasuhito, Nannya, Keisuke, Kataoka, Yasunori, Ota, Masahiro Marshall, Nakagawa, Kenichi, Yoshida, Yusuke, Shiozawa, Maiko, Morita, Tetsuichi, Yoshizato, Masashi, Sanada, Manabu, Nakayama, Haruhiko, Koseki, Hiromitsu, Nakauchi, Seishi, Ogawa
Publikováno v:
Blood. 131(6)
Splicing factor mutations are characteristic of myelodysplastic syndromes (MDS) and related myeloid neoplasms and implicated in their pathogenesis, but their roles in the development of MDS have not been fully elucidated. In the present study, we inv
Autor:
Govind Bhagat, Ellin Berman, Azra Raza, Masahiro Marshall Nakagawa, Aruna Kode, Stavroula Kousteni, Sanil J Manavalan, Julie Teruya-Feldstein
Publikováno v:
Blood. 126:2551-2551
It has previously been shown that an activating mutation in β-catenin in osteoblasts leads to the development of myelodysplasia (MDS) with rapid progression to AML in mice through upregulation of Jagged1 expression in osteoblasts and subsequent acti