Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Masahiro Hirashiba"'
Autor:
Masahiro Hirashiba, Ri-ichi Muranaka, Masako Kaneto, Ryou Fukushima, Susumu Kanamori, Hiroshi Kitagawa, Atsuko Hishikawa
Publikováno v:
Toxicological Sciences. 108:419-426
Leflunomide is an immunosuppressant drug displaying teratogenicity in mice, rats, and rabbits. Its immunosuppressive effect occurs via inhibition of dihydroorotate dehydrogenase (DHODH) and tyrosine kinases. In this study, we coadministered Leflunomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a32e25c7d6e56365be61023e97b0437
https://doi.org/10.1093/toxsci/kfp022
https://doi.org/10.1093/toxsci/kfp022
Autor:
Susumu Kanamori, Masako Kaneto, Ikuo Kato, Ryou Fukushima, Atsuko Hishikawa, Ri-ich Muranaka, Kazuichi Nakamura, Masahiro Hirashiba
Publikováno v:
Reproductive Toxicology. 24:310-316
Leflunomide is an immunosuppressive agent that inhibits de novo synthesis of pyrimidine nucleotides and the activity of protein tyrosine kinase. This study examined the teratogenicity of Leflunomide in mice. Pregnant mice were treated orally with Lef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c258b8b3ab6607b9edff78f78cdd4b
https://doi.org/10.1016/j.reprotox.2007.05.006
https://doi.org/10.1016/j.reprotox.2007.05.006
Publikováno v:
Placenta. 13:63-79
The present study was designed to develop a procedure for purifying rPL-II and a homologous radioimmunoassay (RIA) for rPL-II. Molecular profiles of rPL-II were also investigated in tissue and plasma. rPL-II was purified 3,780-fold, based on its radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2b0915426d387590aea32a63a742e8
https://doi.org/10.1016/0143-4004(92)90008-h
https://doi.org/10.1016/0143-4004(92)90008-h
Autor:
Susumu Kanamori, Masahiro Hirashiba, Hiroshi Kitagawa, Atsuko Hishikawa, Ri-ichi Muranaka, Masako Kaneto, Ryou Fukushima
Publikováno v:
Congenital anomalies. 49(1)
Leflunomide has inhibitory effects on dihydroorotate-dehydrogenase activity and protein tyrosine kinase activity. In the present study, a single dose of 50 mg/kg Leflunomide was administered to pregnant mice on one of gestation days (GD)6-11. Charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5695ed035e7de8b37e0a44617ae385
https://pubmed.ncbi.nlm.nih.gov/19243413
https://pubmed.ncbi.nlm.nih.gov/19243413
Publikováno v:
Endocrinologia Japonica. 38:589-595
Rat placental lactogen-II (rPL-II) and growth hormone (rGH) in maternal and fetal serum, amniotic fluid, and placental tissue were measured by a homologous radioimmunoassay during the last half of pregnancy. rPL-II appeared first in maternal circulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56cb67f894c1af41990b28b06b3f063
https://doi.org/10.1507/endocrj1954.38.589
https://doi.org/10.1507/endocrj1954.38.589
Autor:
Ryou Fukushima, Susumu Kanamori, Masahiro Hirashiba, Atsuko Hishikawa, Ri-ichi Muranaka, Masako Kaneto, Hiroshi Kitagawa
Publikováno v:
Toxicological Sciences; Apr2009, Vol. 108 Issue 2, p419-426, 8p