Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Masahiro, Noji"'
Autor:
Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Amyloid fibrils of β2-microglobulin (β2m) can cause dialysis-related amyloidosis. Here, the authors show that a decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited a
Externí odkaz:
https://doaj.org/article/d80ffdffa03b47a68ce0fdd216dda884
Autor:
Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, József Kardos, Daniel E. Otzen, Vittorio Bellotti, Johannes Buchner, Yuji Goto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Noji et al. test link between protein folding and misfolding upon heating and agitation. They show that folding and amyloid formation are separated by the supersaturation barrier of a protein, breakdown of which shifts the protein to the amyloid path
Externí odkaz:
https://doaj.org/article/ed4d8eeda119466189e820b1da445527
Publikováno v:
Molecules, Vol 27, Iss 14, p 4588 (2022)
The supersaturation of a solution refers to a non-equilibrium phase in which the solution is trapped in a soluble state, even though the solute’s concentration is greater than its thermodynamic solubility. Upon breaking supersaturation, crystals fo
Externí odkaz:
https://doaj.org/article/9e513c6f7a014eb89f0e384634bd9735
Regioselective β‐Trifluoromethylation of β‐Silylporphyrins by Using a Trifluoromethyl Copper Complex
Publikováno v:
European Journal of Organic Chemistry. 2021:5623-5626
Autor:
Hitoshi Kamauchi, Satoshi Hayashi, Toshikatsu Takanami, Hiroaki Sasaki, Koji Fujihara, Yoshihiro Kino, Kiyotaka Koyama, Masahiro Noji, Kaoru Kinoshita, Jun-ichi Satoh, Youki Masuda
Publikováno v:
Journal of Natural Products. 84:1748-1754
To develop drugs to treat Alzheimer's disease (AD) on the basis of the amyloid cascade hypothesis, the amyloid-β (Aβ) aggregation inhibitory activities of 110 extracts from mushrooms were evaluated by thioflavin T (Th-T) assays. The MeOH extract of
Autor:
Yuji Goto, Masahiro Noji
Publikováno v:
Seibutsu Butsuri. 61:358-365
Publikováno v:
Chemical Communications. 57:7104-7107
The isomerization of epoxides to allylic alcohols was developed via proton-accelerated Lewis acid catalysis. The addition of tBuOH as a proton source is the key to the efficient catalytic cycle. Trisubstituted epoxides, including enantioenriched deri
Autor:
Keisuke Yuzu, Masatomo So, Yuji Goto, Eri Chatani, Tetsushi Iwasaki, Naoki Yamamoto, Masahiro Noji, Motonari Tsubaki
Publikováno v:
Biophys J
Amyloid fibrils are aberrant protein aggregates associated with various amyloidoses and neurodegenerative diseases. It is recently indicated that structural diversity of amyloid fibrils often results in different pathological phenotypes, including cy
Autor:
Yuji Goto, Kazumasa Sakurai, Keiichi Yamaguchi, Masatomo So, Hironobu Naiki, Masahiro Noji, Kenji Sasahara, József Kardos
Publikováno v:
Journal of Biological Chemistry. 294:15826-15835
Amyloidosis-associated amyloid fibrils are formed by denatured proteins when supersaturation of denatured proteins is broken. β2-Microglobulin (β2m) forms amyloid fibrils and causes dialysis-related amyloidosis in patients receiving long-term hemod
Autor:
Masahiro Noji, Sho Ishimaru, Haruki Obata, Ayano Kumaki, Taichi Seki, Satoshi Hayashi, Toshikatsu Takanami
Publikováno v:
Tetrahedron Letters. 104:154026