Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Masahiro, Hiratochi"'
Autor:
Takeshi Nakabayashi, Noboru Kamada, Masayuki Isaji, Nobuhiko Fushimi, Masahiro Hiratochi, Hideki Fujikura, Kazuya Tatani, Isao Azumaya, Koichi Arakawa, Yoshikazu Fujimori, Kazuo Shimizu, Hidemasa Hikawa, Kenji Katsuno, Toshihiro Nishimura, Shinjiro Watanabe
Publikováno v:
Bioorganicmedicinal chemistry. 34
We optimized the structure of an active metabolite (1) of WAY-123783, which was obtained from mouse urine after oral administration, to improve selectivity for SGLT2 and oral bioavailability. O-glucoside derivative 24 (remogliflozin etabonate) was su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67d31b44d80c787e2a1cb681e75b10e
https://pubmed.ncbi.nlm.nih.gov/33581390
https://pubmed.ncbi.nlm.nih.gov/33581390
Autor:
Yuji Yamauchi, Shinjiro Watanabe, Yu Kuramochi, Fumiaki Itoh, Satoshi Shuto, Norihiko Kikuchi, Masahiro Hiratochi, Kazuya Tatani, Masayuki Isaji
Publikováno v:
Journal of Medicinal Chemistry. 59:3719-3731
To test the hypothesis that inhibitors of human concentrative nucleoside transporter 2 (hCNT2) suppress increases in serum urate levels derived from dietary purines, we previously identified adenosine derivative 1 as a potent hCNT2 inhibitor (IC50 =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cd5570da8cf583dfd83fd1dacb5869
https://doi.org/10.1021/acs.jmedchem.5b01884
https://doi.org/10.1021/acs.jmedchem.5b01884
Autor:
Fumiki Oana, Masahiro Hiratochi, Kouichi Kaidoh, Yuji Yamauchi, Takayuki Suzuki, Akihiro Tsuchioka, Tomoyuki Ijiro
Publikováno v:
NeuroReport. 26:1126-1132
Although 6-hydroxydopamine-induced (6-OHDA-induced) rats are a well-known Parkinson's disease model, the effects of dopamine D2 agonists in mice with 6-OHDA-induced lesions are not completely understood. We produced mice with 6-OHDA-induced lesions a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3b8dbb76fd35c352d2902ae0b5ca26
https://doi.org/10.1097/wnr.0000000000000484
https://doi.org/10.1097/wnr.0000000000000484
Publikováno v:
ACS Medicinal Chemistry Letters. 6:244-248
Purine-rich foods have long been suspected as a major cause of hyperuricemia. We hypothesized that inhibition of human concentrative nucleoside transporter 2 (hCNT2) would suppress increases in serum urate levels derived from dietary purines. To test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0695915e1b4ece521cae2d45cc0e3be
https://doi.org/10.1021/ml500343r
https://doi.org/10.1021/ml500343r
Publikováno v:
Current Stem Cell Research & Therapy. 3:288-302
In the canonical Notch signaling pathway, intramembrane cleavage by gamma-secretase serves to release an intracellular domain of Notch that has activity in the nucleus through binding to transcription factors. In addition, we showed that Notch also s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0999c673e35ec5575daabcb18e071dd3
https://doi.org/10.2174/157488808786734024
https://doi.org/10.2174/157488808786734024
Publikováno v:
Neuroscience Letters. 444:127-131
Although amyloid precursor protein (APP) has central roles in Alzheimer's disease, the physiological functions of this protein have yet to be fully elucidated. APP homologues show significant sequence conservation in the intracellular domain through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9907169476b775eb955f3bafe1c2932d
https://doi.org/10.1016/j.neulet.2008.08.034
https://doi.org/10.1016/j.neulet.2008.08.034
Autor:
Yu Kuramochi, Masahiro Hiratochi, Chang-Sung Koh, Kohzo Nakayama, Takeshi Ohkawara, Hisashi Nagase
Publikováno v:
Nucleic Acids Research
Delta is a major transmembrane ligand for Notch receptor that mediates numerous cell fate decisions. The Notch signaling pathway has long been thought to be mono-directional, because ligands for Notch were generally believed to be unable to transmit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e9b2580c94c2c8b6552d238f7f2db5
https://doi.org/10.1093/nar/gkl1128
https://doi.org/10.1093/nar/gkl1128
Autor:
Fumiki, Oana, Hiroshi, Onozuka, Akihiro, Tsuchioka, Takayuki, Suzuki, Nobuyuki, Tanaka, Kouichi, Kaidoh, Yuji, Hoyano, Masahiro, Hiratochi, Shinji, Kikuchi, Yasuo, Takehana, Nobuo, Shibata
Publikováno v:
The Journal of heart valve disease. 23(2)
The symptoms of Parkinson's disease are alleviated by dopamine D2 agonists, which are classified as ergot dopamine D2 agonists and non-ergot D2 agonists. Among the former, pergolide has been associated with valvular heart disease, since it has both p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d5b3d2072c4134ba18e2e5d503ddb95
https://pubmed.ncbi.nlm.nih.gov/25076559
https://pubmed.ncbi.nlm.nih.gov/25076559
Autor:
Masami Kojima, Shigemi Aoyagi, Kiyoshi Ichikawa, Kazuhiko Shinagawa, Masuo Akahane, Masahiro Hiratochi
Publikováno v:
British Journal of Pharmacology. 131:266-270
The purpose of this study was to investigate the involvement of thromboxane A2 (TXA2) in the cough response in a guinea-pig cough model. Here, we describe results obtained using a selective TXA2 synthetase inhibitor, ozagrel, and a selective TXA2 ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5881ba422100d666adff89e6449a4f9
https://doi.org/10.1038/sj.bjp.0703553
https://doi.org/10.1038/sj.bjp.0703553
Publikováno v:
International Journal of Immunopharmacology. 22:463-471
Tranilast is well-known as a useful drug for allergic diseases. This drug is believed to exhibit its therapeutic effects by inhibiting the release of chemical mediators from mast cells and basophils. Effects of tranilast on T helper type 2 (Th2) cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47de9625aef7936937338fbda5bc10d7
https://doi.org/10.1016/s0192-0561(00)00013-8
https://doi.org/10.1016/s0192-0561(00)00013-8