Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Masahiro, Fujihashi"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this
Externí odkaz:
https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f9161
Publikováno v:
ACS Chemical Biology. 16:794-799
Most kinases utilize ATP as a phosphate donor and phosphorylate a wide range of phosphate acceptors. An alternative phosphate donor is inorganic pyrophosphate (PPi), which costs only 1/1000 of ATP. To develop a method to engineer PPi-dependent kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb347c40d30a59dc8660d32bba417dab
https://doi.org/10.1021/acschembio.0c00733
https://doi.org/10.1021/acschembio.0c00733
Autor:
Tomoyuki Nishi, Daijiro Ueda, Masahiro Fujihashi, Tetsuro Shinada, Kazuya Asada, Tsutomu Sato, Kei Sugawara, Rafaella Stepanova, Hayato Inagi, Kunio Miki, Yoko Yasuno
Publikováno v:
ACS Chemical Biology. 15:1517-1525
Terpene synthases (TS) are classified into two broad types, Class I and II, based on the chemical strategy for initial carbocation formation and motif sequences of the catalytic site. We have recently identified a new class of enzymes, Class IB, show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d06f4983716516cd2c8509d3850873
https://doi.org/10.1021/acschembio.0c00145
https://doi.org/10.1021/acschembio.0c00145
Autor:
Shogo Iwakata, Kazuya Asada, Tomoyuki Nishi, Rafaella Stepanova, So Shinoda, Daijiro Ueda, Masahiro Fujihashi, Yoko Yasuno, Tetsuro Shinada, Tsutomu Sato
Publikováno v:
Bioscience, biotechnology, and biochemistry. 86(6)
Terpene synthase (TS) from Bacillus alcalophilus (BalTS) is the only Class IB TS for which a 3D structure has been elucidated. Recently, geranyl-β-phellandrene, a novel cyclic diterpene, was identified as a product of BalTS in addition to the acycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a35a4d287de23a912c3a7e8dce3d42
https://pubmed.ncbi.nlm.nih.gov/35287170
https://pubmed.ncbi.nlm.nih.gov/35287170
Autor:
Masahiro Fujihashi, Haruyuki Atomi, Ryuhei Nagata, Yasunobu Mori, Hiroki Kawamura, Takaaki Sato, Kunio Miki, Takayuki Fujita
Publikováno v:
J Bacteriol
Serine kinase catalyzes the phosphorylation of free serine (Ser) to produce O -phosphoserine (Sep). An ADP-dependent Ser kinase in the hyperthermophilic archaeon Thermococcus kodakarensis ( Tk -SerK) is involved in cysteine (Cys) biosynthesis and mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706fc5717f6229d9f4aea7a6ff8e2d1f
https://europepmc.org/articles/PMC8297531/
https://europepmc.org/articles/PMC8297531/
Autor:
Masahiro Fujihashi
Publikováno v:
Nihon Kessho Gakkaishi. 63:222-223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edbbd401abb935498fe268cf63f0235b
https://doi.org/10.5940/jcrsj.63.222
https://doi.org/10.5940/jcrsj.63.222
Autor:
Kunio Miki, Daijiro Ueda, Kazuma Fuku, Tomoyuki Nishi, Yoko Yasuno, Masahiro Fujihashi, Yuma Tanaka, Mizuki Murakami, Daisuke Yamamoto, Ai Sekihara, Tetsuro Shinada, Tsutomu Sato
Publikováno v:
Chemical Science. 9:3754-3758
Thousands of terpenes have been identified to date. However, only two classes of enzymes are known to be involved in their biosynthesis, and each class has characteristic amino-acid motifs. We recently identified a novel large-terpene (C25/C30/C35) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779bd31e2cb2ca656078cd824d10b2a4
https://doi.org/10.1039/c8sc00289d
https://doi.org/10.1039/c8sc00289d
Autor:
Riku Aono, Yuichi Nishitani, Wakao Fukuda, Haruyuki Atomi, Tomohiro Kiriyama, Tadayuki Imanaka, Masahiro Fujihashi, Kenta Tagashira, Kunio Miki, Tomoyuki Takai, Takaaki Sato
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:1339-1346
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) plays a central role in carbon dioxide fixation on our planet. Rubisco from a hyperthermophilic archaeon Thermococcus kodakarensis (Tk-Rubisco) shows approximately twenty times the activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82086638c104915f58c3e6809d727c2d
https://doi.org/10.1002/prot.25080
https://doi.org/10.1002/prot.25080
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Nature Communications
Nature Communications
Almost all kinases utilize ATP as their phosphate donor, while a few kinases utilize pyrophosphate (PPi) instead. PPi-dependent kinases are often homologous to their ATP-dependent counterparts, but determinants of their different donor specificities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776f1faad700167961f3f79f9a3d4814
https://doi.org/10.1038/s41467-018-04201-z
https://doi.org/10.1038/s41467-018-04201-z
Publikováno v:
Journal of Genetics and Genomics. 42:221-234
Orotidine 5'-monophosphate decarboxylase (ODCase) is known as one of the most proficient enzymes. The enzyme catalyzes the last reaction step of the de novo pyrimidine biosynthesis, the conversion from orotidine 5'-monophosphate (OMP) to uridine 5'-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24ab41f3f0660a21a8d19d045b50e36
https://doi.org/10.1016/j.jgg.2015.04.005
https://doi.org/10.1016/j.jgg.2015.04.005