Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Masahiko Ueno"'
Autor:
Takeshi Nishi, Teruyoshi Kume, Ryotaro Yamada, Hiroshi Okamoto, Satsohi Koto, Masahiro Yamashita, Masahiko Ueno, Kyo Kamisaka, Yoshitaka Sasahira, Ayano Enzan, Yasuyuki Sudo, Tomoko Tamada, Terumasa Koyama, Koichiro Imai, Yoji Neishi, Shiro Uemura
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Background Coronary artery spasm plays a vital role in the pathogenesis of coronary plaques. We sought to investigate the plaque characteristics of co‐existing organic lesions in patients with coronary artery spasm in comparison to those without co
Externí odkaz:
https://doaj.org/article/056e87ba317d4d35a7bebcd29ed70a7e
Autor:
Yasuhiko Tomita, Kenji Kuwabara, Shingo Furue, Kazushige Tanaka, Katsutoshi Yamada, Masahiko Ueno, Takashi Ono, Toshiyuki Maruyama, Tetsuo Ajiki, Hirohiko Onoyama, Masahiro Yamamoto, Yozo Hori
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 2, Pp 144-154 (2004)
We investigated the efficacy of a potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na, in an experimental model of acute pancreatitis in rats. Combined intraductal injection of sodium taurocholate (5 mg/rat) and porcine pancreat
Externí odkaz:
https://doaj.org/article/0a9c6784bc294695861d82278beec6b6
Autor:
Keitaro Watanabe, Misaki Tamura, Masashi Nitani, Takeshi Yamanobe, Shin-ichiro Kato, Yoshio Aso, Yutaka Ie, Masahiko Ueno, Hiroki Uehara, Yosuke Nakamura
Publikováno v:
The Journal of Organic Chemistry. 82:3132-3143
π-Extended thiadiazoloquinoxaline (TQ) derivatives 1a,b–3a,b, in which a tetraalkoxyphenanthrene moiety is annulated with the TQ core and benzene rings are incorporated via the ethynylene spacer, were synthesized. They display absorption bands rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f5797acf532a1ce2dde2e5e8528e03
https://doi.org/10.1021/acs.joc.7b00084
https://doi.org/10.1021/acs.joc.7b00084
Autor:
Tetsuo Ajiki, Katsutoshi Yamada, Masahiko Ueno, Kenji Kuwabara, Toshiyuki Maruyama, Shingo Furue, Kazushige Tanaka, Takashi Ono, Yozo Hori, Hirohiko Onoyama, Masahiro Yamamoto, Yasuhiko Tomita
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 2, Pp 144-154 (2004)
We investigated the efficacy of a potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na, in an experimental model of acute pancreatitis in rats. Combined intraductal injection of sodium taurocholate (5 mg/rat) and porcine pancreat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c146d92816cb147dea406e5ca9b976
http://www.sciencedirect.com/science/article/pii/S1347861319323564
http://www.sciencedirect.com/science/article/pii/S1347861319323564
Autor:
Kouji Nomura, Yozo Hori, Takashi Ono, Hitoshi Arita, Hirokuni Jyoyama, Yasuhiko Tomita, Katsutoshi Yamada, Isao Okayasu, Kenji Kuwabara, Shingo Furue, Mika Kobayashi, Masahiko Ueno, Isao Teshirogi
Publikováno v:
European Journal of Pharmacology. 472:147-158
Although group IIA phospholipase A(2) has been suggested to be implicated in inflammatory bowel disease, its pathophysiological role in colitis remains unclear. We investigated whether group IIA phospholipase A(2) had pro-inflammatory roles in dextra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e7f9f98a652c3fd403776c96f69c4e
https://doi.org/10.1016/s0014-2999(03)01859-4
https://doi.org/10.1016/s0014-2999(03)01859-4
Autor:
Takashi ONO, Katsutoshi YAMADA, Yukiko CHIKAZAWA, Masahiko UENO, Shozo NAKAMOTO, Takayuki OKUNO, Kaoru SENO
Publikováno v:
Biochemical Journal. 363:727-735
Cytosolic phospholipase A2α (cPLA2α), one of the three subtypes of cPLA2 (α, β and γ), is thought to be a rate-limiting enzyme in eicosanoid biosynthesis. We developed a novel and potent cPLA2α inhibitor with an optically active pyrrolidine, te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d4ec071b2a7070621e26542d645954
https://doi.org/10.1042/bj3630727
https://doi.org/10.1042/bj3630727
Autor:
Yasuhiko Tomita, Kahoru Nishina, Yozo Hori, Masahiko Ueno, Kenji Kuwabara, Takashi Ono, Katsuya Mikawa, Shingo Furue, Akihiro Matsukawa, Masaru Yoshinaga, Hidefumi Obara, Makoto Shiga
Publikováno v:
European Journal of Pharmacology. 433:209-216
Glucocorticoids are the most potent and widely used anti-inflammatory agents, but they are not particularly effective against early phase of acute respiratory distress syndrome. We investigated whether methylprednisolone, a synthetic glucocorticoid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f03009bf0b453304d125cc480b230
https://doi.org/10.1016/s0014-2999(01)01507-2
https://doi.org/10.1016/s0014-2999(01)01507-2
Autor:
Yasuhiko Tomita, Kahoru Nishina, Yozo Hori, Shingo Furue, Akihiro Matsukawa, Masaru Yoshinaga, Kenji Kuwabara, Takashi Ono, Hidefumi Obara, Masahiko Ueno, Isao Teshirogi, Makoto Shiga, Katsuya Mikawa
Publikováno v:
Critical Care Medicine. 29:719-727
We attempted to determine whether group IIA secretory phospholipase A2 (sPLA2-IIA) blockade after the onset of lung injury exerted therapeutic efficacy in the treatment of oleic acid (OA)-induced acute lung injury by using S-5920/LY315920Na, a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573c182d4cf5385b461a36c427f30882
https://doi.org/10.1097/00003246-200104000-00004
https://doi.org/10.1097/00003246-200104000-00004
Autor:
Masahiko Ueno, Takashi Ono, Masaaki Yamada, Toshihiko Okada, Yasushi Murakami, Toshiyuki Kato, Yukiko Chikazawa, Yuji Ito, Mitsuaki Ohtani, Sanji Hagishita, Isao Teshirogi, Takaharu Matsuura, Katsutoshi Yamada, Masaaki Wada, Kazuhiro Shirahase
Publikováno v:
Journal of Medicinal Chemistry. 39:3636-3658
Phospholipase A2 is an enzyme which hydrolyzes the sn-2 position of certain cellular phospholipids. The liberated lysophospholipid and arachidonic acid are precursors in the biosynthesis of various biologically active products. As human nonpancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914f7eb81c1a540a3c20589d0fccf93
https://doi.org/10.1021/jm960395q
https://doi.org/10.1021/jm960395q
Autor:
Isao Teshirogi, Kazuhiro Shirahase, Takashi Ono, Masaaki Yamada, Yuji Ito, Masaaki Wada, Katsutoshi Yamada, Mitsuaki Ohtani, Toshihiko Okada, Yasushi Murakami, Takaharu Matsuura, Sanji Hagishita, Yukiko Chikazawa, Toshiyuki Kato, Masahiko Ueno
Publikováno v:
ChemInform. 28
Phospholipase A2 is an enzyme which hydrolyzes the sn-2 position of certain cellular phospholipids. The liberated lysophospholipid and arachidonic acid are precursors in the biosynthesis of various biologically active products. As human nonpancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d0f50ea6895d901ec6b1965f8c74230
https://doi.org/10.1002/chin.199703190
https://doi.org/10.1002/chin.199703190