Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Masahiko Terakado"'
Autor:
Yoshikazu Takaoka, Masahiro Ikura, Hiromu Egashira, Masahiko Terakado, Masaki Asada, Naoko Karakawa, Naoki Matsunaga, Shinji Nakade, Yuka Takada, Keisuke Hirai, Koji Shinozaki, Hiroshi Saga, Kazuya Hashimura, Masanori Yamada, Hideyuki Ueda, Yoshihiro Sugiura, Masashi Minami, Hidehiro Suzuki, Motoyuki Tanaka
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1281-1286
Scaffold hopping from the amide group of lead compound ONO-7300243 (1) to a secondary alcohol successfully gave a novel chemotype lysophosphatidic acid receptor 1 (LPA1) antagonist 4. Wash-out experiments using rat isolated urethra showed that compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fbce79430dabdbc96ac714da5cb0c5
https://doi.org/10.1021/acsmedchemlett.7b00383
https://doi.org/10.1021/acsmedchemlett.7b00383
Autor:
Shinji Nakade, Hirotaka Mizuno, Christopher B. Roth, Raymond C. Stevens, Mauro Mileni, Dora Warshaviak, Guillermo Asmar-Rovira, Caroline Rodgers, Jerold Chun, Michael A. Hanson, Gye Won Han, Rie Omi, Jeffrey Velasquez, Mark T. Griffith, Haruto Kurata, Masahiko Terakado, Yasuyuki Kihara, Jill E. Chrencik
Publikováno v:
Cell. 161(7):1633-1643
SummaryLipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties. This growth in knowledge is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22edcb5a06396fd07a460c9c3437433
Autor:
Motoyuki Tanaka, Taku Fujimoto, Hiromu Habashita, Shinji Nakade, Hideyuki Ueda, Takuya Seko, Yoshikazu Takaoka, Hiroshi Saga, Hiroshi Kohno, Kazuya Hashimura, Hidehiro Suzuki, Masahiko Terakado
Lysophosphatidic acid (LPA) evokes various physiological responses through a series of G protein-coupled receptors known as LPA1–6. A high throughput screen against LPA1 gave compound 7a as a hit. The subsequent optimization of 7a led to ONO-730024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ced8b659779be861f753f05860c5e9
https://europepmc.org/articles/PMC5066152/
https://europepmc.org/articles/PMC5066152/
Autor:
Masashi Minami, Haruto Kurata, Masakuni Kurono, Takeji Ono, Kazuhiro Otsuki, Masahiko Terakado, Hirotaka Mizuno, Takuya Seko, Hiroshi Hagiya, Shinji Nakade, Kensuke Kusumi, Hiromu Habashita
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
Structure-activity relationship of sphingosine-1-phosphate receptor agonist was examined. In terms of reducing the flexibility of molecule, hit compound 1 was modified to improve S1P(1) agonistic activity as well as selectivity over S1P(3) agonistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb83fd767e708ca4c7567310eb02470
https://pubmed.ncbi.nlm.nih.gov/21295477
https://pubmed.ncbi.nlm.nih.gov/21295477