Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Masahiko Sugita"'
Autor:
Tatsuaki Mizutani, Toshiaki Ano, Yuya Yoshioka, Satoshi Mizuta, Keiko Takemoto, Yuki Ouchi, Daisuke Morita, Satsuki Kitano, Hitoshi Miyachi, Tatsuaki Tsuruyama, Nagatoshi Fujiwara, Masahiko Sugita
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106081- (2023)
Summary: Mycobacterium infection gives rise to granulomas predominantly composed of inflammatory M1-like macrophages, with bacteria-permissive M2 macrophages also detected in deep granulomas. Our histological analysis of Mycobacterium bovis bacillus
Externí odkaz:
https://doaj.org/article/5bf076fcf3d442e8ac88ef8964116989
Autor:
Ei’ichi Iizasa, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Hiroaki Kawaguchi, Masayuki Umemura, Kenji Toyonaga, Hideyasu Kiyohara, Ikuya Yano, Marco Colonna, Masahiko Sugita, Goro Matsuzaki, Sho Yamasaki, Hiroki Yoshida, Hiromitsu Hara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mycobacterial cell wall lipids can drive immunoevasion, but underlying mechanisms are incompletely understood. Here the authors show TREM2 is a pattern recognition receptor that binds non-glycosylated mycolic acid-containing lipids and inhibits Mincl
Externí odkaz:
https://doaj.org/article/ed7734d2af8e41d9835e7e5284432908
Autor:
Yuya Yoshioka, Tatsuaki Mizutani, Satoshi Mizuta, Ayumi Miyamoto, Satoru Murata, Toshiaki Ano, Hiroshi Ichise, Daisuke Morita, Hiroyuki Yamada, Yoshihiko Hoshino, Tatsuaki Tsuruyama, Masahiko Sugita
Publikováno v:
Blood Advances, Vol 1, Iss 3, Pp 184-192 (2016)
Abstract: Macrophages have the potential to undergo cellular transformation into epithelioid cells, and their concentric accumulation in tissues results in the development of granulomas. Although epithelioid cells are an essential and dominant compon
Externí odkaz:
https://doaj.org/article/19475ba277594b4a95d52856e71a526d
Autor:
Daisuke Morita, Yukie Yamamoto, Tatsuaki Mizutani, Takeshi Ishikawa, Juri Suzuki, Tatsuhiko Igarashi, Naoki Mori, Takashi Shiina, Hidetoshi Inoko, Hiroaki Fujita, Kazuhiro Iwai, Yoshimasa Tanaka, Bunzo Mikami, Masahiko Sugita
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Lipid antigens have been added to the antigenic repertoire in recent years. Here, the authors have identified Mamu-B*098 as a lipopeptide antigen presenting molecule and using structural and biochemical analysis have shown that it has a different ant
Externí odkaz:
https://doaj.org/article/daa53f15e3cb4a25a747098318e53ec1
Autor:
Isamu Matsunaga, Masahiko Sugita
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
Mycobacterium tuberculosis and related mycobacteria species are unique in that the acid-fast bacilli possess a highly lipid-rich cell wall that not simply confers resistance to treatment with acid alcohol, but also controls their survival and virulen
Externí odkaz:
https://doaj.org/article/d62e499fd5a84d32b92fb2d8827cd707
Publikováno v:
International immunology.
Complementarity-determining regions (CDRs) of αβ T-cell receptors (TCRs) sense peptide-bound MHC (pMHC) complexes via chemical interactions, thereby mediating antigen specificity and MHC restriction. Flexible finger-like movement of CDR loops contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7975045b7da71bd8e02b90f3369c1d3a
https://pubmed.ncbi.nlm.nih.gov/36053252
https://pubmed.ncbi.nlm.nih.gov/36053252
Autor:
Minori Asa, Daisuke Morita, Jin Kuroha, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita
Publikováno v:
The Journal of biological chemistry. 298(7)
Rhesus monkeys have evolved MHC-encoded class I allomorphs such as Mamu-B∗098 that are capable of binding N-myristoylated short lipopeptides rather than conventional long peptides; however, it remains unknown whether such antigen-binding molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da95ee5cad765f3fb1626900b3fe223
https://pubmed.ncbi.nlm.nih.gov/35667438
https://pubmed.ncbi.nlm.nih.gov/35667438
Publikováno v:
J Biol Chem
Newly synthesized major histocompatibility complex (MHC) class I proteins are stabilized in the endoplasmic reticulum (ER) by binding 8–10-mer-long self-peptide antigens that are provided by transporter associated with antigen processing (TAP). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c11022f9c6866b40dad6d05d891f34b
https://doi.org/10.1074/jbc.ra119.011932
https://doi.org/10.1074/jbc.ra119.011932
Autor:
Juri Suzuki, Daisuke Morita, Masahiko Sugita, Yoshimasa Tanaka, Yukie Yamamoto, Hidetoshi Inoko, Yoko Shima, Tatsuaki Mizutani, Akihiro Midorikawa, Bunzo Mikami, Naoki Mori, Takashi Shiina
Publikováno v:
The Journal of Immunology. 202:3349-3358
Similar to host proteins, N-myristoylation occurs for viral proteins to dictate their pathological function. However, this lipid-modifying reaction creates a novel class of “lipopeptide” Ags targeted by host CTLs. The primate MHC class I–encode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df2bbb0f7a5d31304523eb1ae16aeb10
https://doi.org/10.4049/jimmunol.1900087
https://doi.org/10.4049/jimmunol.1900087
Autor:
Hiroki Yoshida, Ikuya Yano, Hiromitsu Hara, Kenji Toyonaga, Sho Yamasaki, Hiroaki Kawaguchi, Marco Colonna, Ei’ichi Iizasa, Masayuki Umemura, Masahiko Sugita, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Goro Matsuzaki, Hideyasu Kiyohara
Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecd44b2b78a168c9d5b643bfc0513b8c
https://doi.org/10.21203/rs.3.rs-37581/v1
https://doi.org/10.21203/rs.3.rs-37581/v1
