Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Masahiko Nakamoto"'
Autor:
Masahiko Nakamoto, Moe Noguchi, Akihiro Nishiguchi, João F. Mano, Michiya Matsusaki, Mitsuru Akashi
Publikováno v:
Materials Today Bio, Vol 14, Iss , Pp 100225- (2022)
We report a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates (ALN) conjugated with poly-γ-glutamate (γ-PGA), a typical biodegradable polymer. γ-PGA with ALN (γ-PGA-ALN) forms the hydrogel in
Externí odkaz:
https://doaj.org/article/aae3d4c934554779a0cf93b9450009c4
Autor:
Itaru OTOMARU, Masahiko NAKAMOTO, Masaki TAKAO, Nobuhiko SUGANO, Yoshiyuki KAGIYAMA, Hideki YOSHIKAWA, Yukio TADA, Yoshinobu SATO
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 3, Iss 4, Pp 478-489 (2008)
The present paper describes a method for 3-dimensional (3D) automated preoperative planning of the femoral component (stem) in total hip arthroplasty (THA). Stem planning is formulated as a problem to determine the optimal parameters of position, rot
Externí odkaz:
https://doaj.org/article/c64b3bd44bdd4dd1ad183b747ac7aa79
Publikováno v:
Biomacromolecules. 24:2369-2379
In cancer therapy, drug delivery system (DDS) has been widely studied to achieve selective drug accumulation at the tumor site. However, DDS still has a major drawback in that it requires multi-step processes for intracellular delivery, resulting in
Publikováno v:
ACS applied materialsinterfaces. 14(46)
Since conventional molecular targeted drugs often result in side effect, the development of novel molecular targeted drugs with both high efficacy and selectivity are desired. Simultaneous inhibition of metabolically and spatiotemporally related prot
Publikováno v:
Angewandte Chemie International Edition. 61
Publikováno v:
Nano Letters. 21:5663-5670
A biomimetic of endogenous tissue inhibitors of metalloproteinases (TIMPs) was engineered by introducing three binding elements to a synthetic tetrapolymer. We evaluated the contribution of composition, size, and shape of the TIMP-mimicking polymers
Publikováno v:
Angewandte Chemie. 134
A metabolic cycle-inspired hydrogel which exhibits the biomacromolecule-fueled transient volume phase transition is reported. This hydrogel has the affinity and digestive capacity for a fuel α-poly-L-lysine by incorporating acrylic acid and trypsin.
Publikováno v:
Journal of the American Chemical Society. 142:2338-2345
We describe a process for engineering a synthetic polymer nanoparticle (NP) that functions as an effective, broad-spectrum metalloproteinase inhibitor. Inhibition is achieved by incorporating three functional elements in the NP: a group that interact
Publikováno v:
Journal of Materials Chemistry B. 8:5597-5601
Abiotic oligomeric ligands with a strong affinity for a target peptide sequence were isolated by affinity purification from a pool of 30-mer acrylic random ter-oligomers that were synthesized via a controlled radical polymerization process. Our resul
Autor:
Toshiki Jibiki, Masahiko Nakamoto, Benshuai Guo, Yoshiko Miura, Naoki Gondo, Rinoka Adachi, Yu Hoshino, Mitsunori Moribe
Publikováno v:
ACS Applied Polymer Materials. 2:505-514
Hydrogel films that reversibly absorb salt in response to thermal stimuli are prepared and evaluated. Co-immobilization of temperature responsive poly(N-isopropylacrylamide) (polyNIPAm) nanoparticl...