Výsledky vyhledávání - "Masahiko Kishikawa"

Detection and identification of protein variants and adducts in blood and tissues: an application of soft ionization mass spectrometry to clinical diagnosis

Autor: Toyofumi Nakanishi, Akira Shimizu, Masahiko Kishikawa, Ayako Miyazaki

Publikováno v: Journal of Chromatography B. 776:15-30

The detection and identification of protein variants and abnormally increased modified proteins are important for clinical diagnosis. We applied soft ionization mass spectrometry (MS) to analyze proteins in blood and tissues from various patients. Ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b843dceb19a56705fe563d6b1b3389db
https://doi.org/10.1016/s1570-0232(02)00031-4

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Primary intestinal T-cell lymphoma resembling lymphomatous polyposis: report of a case

Autor: Akiomi Ogawa, Noriyasu Fukushima, Toshimi Satoh, Kohji Miyazaki, Osamu Tokunaga, Masahiko Kishikawa

Publikováno v: Virchows Archiv. 437:450-453

We report an interesting case of primary intestinal T-cell lymphoma (ITL) resembling lymphomatous polyposis (LP) in a 24-year-old man. The neoplasm macroscopically showed numerous small polyps throughout the colon and microscopically showed diffuse p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7b0820fb2e7162b44d570097558c89
https://doi.org/10.1007/s004280000270

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A simple and reliable method of detecting variant transthyretins by multidimensional liquid chromatography coupled to electrospray ionization mass spectrometry

Autor: Akira Shimizu, Toyofumi Nakanishi, Masahiko Kishikawa, Ayako Miyazaki

Publikováno v: Amyloid. 6:48-53

Transthyretin (TTR) variants cause amyloidosis. A method, originally reported by us, of detecting the variants by high performance liquid chromatography/electrospray ionization mass spectrometry (ESIMS) using materials precipitated with anti-TTR anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048d7553c49f864995725d10e163e4ae
https://doi.org/10.3109/13506129908993287

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Enhanced amyloidogenicity of sulfonated transthyretinin vitro, a hypothetical etiology of senile amyloidosis

Autor: Toyofumi Nakanishi, Akira Shimizu, Masahiko Kishikawa, Ayako Miyazaki

Publikováno v: Amyloid. 6:183-186

Genetic variants of transthyretin (TTR) cause systemic amyloidosis and wild-type TTR may also in some situations produce amyloid fibrils. We have analyzed wild-type and variant TTRs by mass spectrometry and found that TTR preparations from all indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118e48f063d5267dfeee14153a801714
https://doi.org/10.3109/13506129909007324

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A new amyloidogenic transthyretin variant, [D38A], detected by electrospray ionization / mass spectrometry

Autor: Akira Shimizu, Ayako Miyazaki, Toyofumi Nakanishi, Masayushi Fukui, Takashi Nishiue, Hirohurni Kusaka, Masahiko Kishikawa

Publikováno v: Amyloid. 6:278-281

A new variant of transthyretin (TTR) was detected by mass spectrometry (MS) in a 63-year-old Japanese female patient suffering from amyloidosis. TTR was analyzed by 2-dimensional liquid chromatography coupled with electrospray ionization MS. Variant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97344977a9970813ec10634ec7306556
https://doi.org/10.3109/13506129909007340

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Electrospray ionization-tandem mass spectrometry analysis of peptides derived by enzymatic digestion of oxidized globin subunits: An improved method to determine amino acid substitution in the hemoglobin 'core'

Autor: Toyofumi Nakanishi, Ayako Miyazaki, Akira Shimizu, Masahiko Kishikawa, Tsuyoshi Yonezawa

Publikováno v: Journal of the American Society for Mass Spectrometry. 7:1040-1049

The determination of an amino acid substitution in the “core” region of abnormal hemoglobin is technically difficult and is time- and labor-intensive both by conventional and by mass spectrometry techniques. Underivatized subunits cleaved with tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bb294e1709927733378b7bea87aa9f
https://doi.org/10.1016/1044-0305(96)00028-1

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Assignment of the ions in the electrospray ionization mass spectra of the tryptic digest of the non-derivatized globin, covering the whole sequence of α- and β-chains: A rapid diagnosis for haemoglobinopathy

Autor: Akira Shimizu, Fumio Inoue, Akira Hayashi, Toyofumi Nakanishi, Masahiko Kishikawa

Publikováno v: Journal of Mass Spectrometry. 30:1663-1670

For the rapid and simple identification of haemoglobin variants, tryptic peptides prepared by digestion of the mixture of normal and variant subunits were analysed by electrospray ionization mass spectrometry (ESI-MS). The globin was not reduced and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::558662b147b2f2d18b1fd9c61307ef63
https://doi.org/10.1002/jms.1190301205

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Detection by Mass Spectrometry of Highly Increased Amount of S- Sulfonated Transthyretin in Serum from a Patient with Molybdenum Cofactor Deficiency

Autor: Toyofumi Nakanishi, Akira Shimizu, Makoto Yoshino, Masahiko Kishikawa

Publikováno v: Pediatric Research. 47:492-494

Serum transthyretin has several isoforms, most of which are caused by disulfide linkage with cysteine residue at position 10. We found an ion peak 80 D larger than unmodified transthyretin by electrospray ionization mass spectrometry and assigned it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59ce2663fb33dcf3ad3e8dd8c98a93d
https://doi.org/10.1203/00006450-200004000-00013

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