Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Masahiko Kainuma"'
Autor:
Shunryo Minezaki, Keiji Sano, Masahiko Kainuma, Yuto Kaihou, Fukuo Kondo, Sachiyo Kawamura, Keita Wada, Fumihiko Miura, Makoto Shibuya, Yuko Sasajima
Publikováno v:
The Japanese Journal of Gastroenterological Surgery. 53:221-229
Autor:
Shunryo Minezaki, Fumihiko Miura, Hisae Iinuma, Kunihiko Takahashi, Makoto Shibuya, Sachiyo Kawamura, Keiji Sano, Masahiko Kainuma, Keita Wada
Publikováno v:
Journal of Hepato-Biliary-Pancreatic Sciences. 26:63-72
Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with poor prognosis. This is due to late diagnosis and lack of reliable prognostic biomarkers. In this study, we focused on exosomal microRNA (miRNA) in portal vein blood (PVB)
Autor:
Keiji Sano, Shunryo Minezaki, Kunihiko Takahasi, Fumihiko Miura, Masahiko Kainuma, Sachiyo Kawamura, Makoto Shibuya, Hisae Iinuma, Keita Wada, Yutaka Ikeda
Publikováno v:
Journal of Hepato-Biliary-Pancreatic Sciences. 25:155-161
Background MicroRNAs (miRNAs) encapsulated in the exosomes of plasma is of interest as stable and minimally invasive biomarkers for recurrence and prognosis in cancer patients. The aim of this study was to clarify the predictive and prognostic value
Autor:
Tadahiro Takada, Keiji Sano, Keita Wada, Sachiyo Kawamura, Masahiko Kainuma, Yutaka Ikeda, Koichi Hayano, Kunihiko Takahashi, Makoto Shibuya, Fumihiko Miura
Publikováno v:
The American Journal of Surgery. 214:256-261
Background Surgical results of patients with resected distal cholangiocarcinoma (DCC) were evaluated to elucidate prognostic impact of the type of preoperative biliary drainage (PBD). Methods Eighty-eight patients with resected DCC were stratified in
Publikováno v:
International Journal of Molecular Sciences
Volume 19
Issue 7
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1898 (2018)
Volume 19
Issue 7
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1898 (2018)
Farnesoid X receptor (FXR) is a receptor for bile acids and plays an important role in the regulation of bile acid metabolism in the liver. Although FXR has been shown to affect hepatocarcinogenesis through both direct and indirect mechanisms, potent
Autor:
Tadahiro Takada, Hodaka Amano, Keiji Sano, Hiromichi Ito, Masahiko Kainuma, Fumihiko Miura, Makoto Shibuya, Naoyuki Toyota, Yutaka Ikeda, Keita Wada
Publikováno v:
Journal of hepato-biliary-pancreatic sciences. 22(9)
Background Chemotherapy for unresectable pancreatic cancer should not only prolong survival but maintain quality of life, considering its limited life expectancy. To achieve these goals, biweekly gemcitabine plus S-1 was assessed in the clinical prac
Autor:
Kunihiko Takahashi, Keita Wada, Yutaka Ikeda, Makoto Shibuya, Masahiko Kainuma, Keiji Sano, Fumihiko Miura, Sachiyo Kawamura
Publikováno v:
Pancreatology. 16:S44
Autor:
Wataru Ochiai, Takaki Miyata, Taishi Takahara, Masakazu Namihira, Makoto Masaoka, Masahiko Kainuma, Sayaka Minobe, Kinichi Nakashima, Masaharu Ogawa, Sayaka Nakatani, Akira Sakakibara
Publikováno v:
Molecular and cellular neurosciences. 40(2)
To understand the cellular and molecular mechanisms regulating cytogenesis within the neocortical ventricular zone, we examined at high resolution the spatiotemporal expression patterns of Ngn2 and Tbr2. Individually DiI-labeled daughter cells were t
Publikováno v:
Bioorganicmedicinal chemistry. 15(7)
A series of substituted-isoxazole derivatives was prepared as candidate farnesoid X receptor (FXR) antagonists, based on our previously proposed ligand superfamily concept. Structure-activity relationship studies indicated that the shape and the stru
Autor:
Ken-ichi Wakabayashi, Hiroyuki Miyachi, Jun Ichi Kasuga, Makoto Makishima, Kazuo Nagasawa, Shinnosuke Hosoda, Masahiko Kainuma, Aya Tanatani, Yuichi Hashimoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(12)
Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.