Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Masahiko Hosobuchi"'
Autor:
Yoko Fujita, Tomoyuki Shibata, Koichi Nonaka, Zhaoyong Yang, Masanori Funabashi, Xiuling Chi, Steven G. Van Lanen, Masahiko Hosobuchi
Publikováno v:
Nature Chemical Biology. 6:581-586
A-503083 B, a capuramycin-type antibiotic, contains an L-aminocaprolactam and an unsaturated hexuronic acid that are linked via an amide bond. A putative class C beta-lactamase (CapW) was identified within the biosynthetic gene cluster that-in contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce84a0d4707a05757c60fa9eca9f2a1
https://doi.org/10.1038/nchembio.393
https://doi.org/10.1038/nchembio.393
Autor:
Koichi Nonaka, Tomoyuki Shibata, Pallab Pahari, Zhaoyong Yang, Steven G. Van Lanen, Masahiko Hosobuchi, Masanori Funabashi
Publikováno v:
Journal of Biological Chemistry. 285:12899-12905
Capuramycin-related compounds, including A-500359s and A-503083s, are nucleoside antibiotics that inhibit the enzyme bacterial translocase I involved in peptidoglycan cell wall biosynthesis. Within the biosynthetic gene cluster for the A-500359s exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8093a154c0ab8398e39cc02e1852aa41
https://doi.org/10.1074/jbc.m110.104141
https://doi.org/10.1074/jbc.m110.104141
Autor:
Masanori Funabashi, Takashi Suzuki, Masahiko Hosobuchi, Toshihiro Suzuki, Chieko Yada, Yasumasa Ogawa, Yoko Fujita, Tomoyuki Shibata, Koichi Nonaka, Masaaki Kizuka
Publikováno v:
Actinomycetologica. 23:46-50
The nucleoside antibiotic A-500359s are produced by Streptomyces griseus SANK 60196. During a screening program of A-500359s high-producing strains, several interesting mutants were isolated and classified into three groups according to two character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d05c61854b4dbaea4e13a8459e7f4c4
https://doi.org/10.3209/saj.saj230204
https://doi.org/10.3209/saj.saj230204
Publikováno v:
Molecular Genetics and Genomics. 267:636-646
Cloning of genes encoding polyketide synthases (PKSs) has allowed us to identify a gene cluster for ML-236B biosynthesis in Penicillium citrinum. Like lovastatin, which is produced by Aspergillus terreus, ML-236B (compactin) inhibits the enzyme 3-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f97625661d8073826878cecc60b9dc8
https://doi.org/10.1007/s00438-002-0697-y
https://doi.org/10.1007/s00438-002-0697-y
Publikováno v:
Biotechnology and Bioengineering. 42:815-820
An automatic feeding process for microbial hydroxylation of ML236B sodium salt (ML-236B Na; compactin) by Streptomyces carbophilus SANK 62585 was developed. The hydroxylated product, pravastatin sodium salt (pravastatin; trade name Mevalotin), is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3bb49018af36aa4dd21387edf9c177
https://doi.org/10.1002/bit.260420705
https://doi.org/10.1002/bit.260420705
Publikováno v:
Journal of Fermentation and Bioengineering. 76:482-486
Fuzzy control was applied to the fermentation of ML-236B by Penicillium citrinum. In order to maintain the pH of the culture at a suitable level for ML-236B production (pH 3.7 to 3.9), a computer aided system using fuzzy control was designed for cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5ef334816015e2b0a3b2d29aa68e0e
https://doi.org/10.1016/0922-338x(93)90245-4
https://doi.org/10.1016/0922-338x(93)90245-4
Publikováno v:
Journal of Fermentation and Bioengineering. 76:476-481
In order to scale-up the production of ML-236B, a precursor of pravastatin sodium, by Penicillium citrinum H strain, a method for controlling mycelial morphology was developed to increase the number of free mycelia in the preculture process. The use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bea2df1c67d9ba0e4bb64fbeab242554
https://doi.org/10.1016/0922-338x(93)90244-3
https://doi.org/10.1016/0922-338x(93)90244-3
Autor:
Hiroji Yoshikawa, Tetsuya Shioiri, Masatoshi Arai, Masahiko Hosobuchi, Jo Ohyama, Seigo Iwado
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 57:1414-1419
In order to increase the yield of ML-236B, an intermediate for pravastatin Na (an inhibitor of cholesterol synthesis) production, the improvements of an ML-236B producing strain of Penicillium citrinum, the medium composition, and the culture conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b261f7041458f4357405213665fb0b08
https://doi.org/10.1271/bbb.57.1414
https://doi.org/10.1271/bbb.57.1414
Publikováno v:
Journal of Fermentation and Bioengineering. 76:470-475
A high level of ML-236B productivity was obtained in a mechanically agitated aerobic culture of Penicillium citrinum when small pellets were formed. Size and concentration of pellet for production had to be optimized. In contrast, cultures with filam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da807665aa01650c60545e34c0964e5f
https://doi.org/10.1016/0922-338x(93)90243-2
https://doi.org/10.1016/0922-338x(93)90243-2
Autor:
Koichi Nonaka, Masahiko Hosobuchi, Satoshi Baba, Yoko Fujita, Tomoyuki Shibata, Steven G. Van Lanen, Masanori Funabashi
Publikováno v:
Chembiochem : a European journal of chemical biology. 11(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a495f9a7a6d043d36e6f657ab357e27d
https://pubmed.ncbi.nlm.nih.gov/20043306
https://pubmed.ncbi.nlm.nih.gov/20043306