Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Masahiko Hirai"'
Autor:
Tadashi Yoshino, Ryuzo Ueda, Isao Date, Akiyoshi Moriwaki, Nobuya Ohara, Koichi Ichimura, Kazuhiro Yoshikawa, Masaki Adachi, Masahiko Hirai, Tomotsugu Ichikawa, Takayoshi Miyake, Takehiro Tanaka, Eisaku Kondo
Molecular targeting agents have become formidable anticancer weapons, which show much promise against the refractory tumors. Functional peptides are among the more desirable of these nanobio-tools. Intracellular delivery of multiple functional peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7e6f5ef0cb3b1c03b2a042771abfa5
https://doi.org/10.1158/1535-7163.c.6531570.v1
https://doi.org/10.1158/1535-7163.c.6531570.v1
Autor:
Tadashi Yoshino, Ryuzo Ueda, Isao Date, Akiyoshi Moriwaki, Nobuya Ohara, Koichi Ichimura, Kazuhiro Yoshikawa, Masaki Adachi, Masahiko Hirai, Tomotsugu Ichikawa, Takayoshi Miyake, Takehiro Tanaka, Eisaku Kondo
Supplementary Fig. from Potent synergy of dual antitumor peptides for growth suppression of human glioblastoma cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b344dc43fdaf17fd9abbf13fab08bc48
https://doi.org/10.1158/1535-7163.22484760
https://doi.org/10.1158/1535-7163.22484760
Autor:
Chie Amano, Masahiko Hirai, Eiji Yuba, Masaaki Miyamoto, Kenji Kono, Takayuki Otani, Yoshie Hiramatsu, Kazunori Oie, Koichi Igarashi, Shinki Iwashita
Publikováno v:
Journal of Biomaterials Applications. 27:445-456
Assembly morphology made from lipids is controlled by the balance between the polar headgroup and the hydrophobic tails. In this study, we showed the various generations of polyamidoamine dendron-bearing lipids could form various assembly morphologie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d870f281d833109e7ee862543d40ebe0
https://doi.org/10.1177/0885328211411955
https://doi.org/10.1177/0885328211411955
Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells
Autor:
Yoshie Hiramatsu, Y. Li, Masashi Okada, H. Kitagawa, Takayuki Otani, S. Iwashita, Masaharu Seno, Masahiko Hirai, H. Minematsu, Koichi Igarashi, Ling Chen, M. Chikuma, David S. Salomon, Takayuki Kudoh
Publikováno v:
International Journal of Pharmaceutics. 391:274-283
Although intravenous administration of high levels of cisplatin (CDDP) are limited due to its severe side effects, efficient delivery of CDDP directly to the tumor should improve the therapeutic response while potentially by-passing significant side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c27d31763008fd1903f7d151d7fdb35
https://doi.org/10.1016/j.ijpharm.2010.02.030
https://doi.org/10.1016/j.ijpharm.2010.02.030
Autor:
Koichi Igarashi, Hideki Minematsu, Noboru Yamazaki, Naoko Kondo, Masahiko Hirai, Kazunori Oie
Publikováno v:
Biochemical and Biophysical Research Communications. 353:553-558
We prepared the liposome binding Sialyl Lewis X (SLX) on the surface in order to specifically and efficiently deliver substances (fluorescent materials, chemical substances, proteins, genes, etc.) to inflammation or tumor regions. The liposome with S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd77cdb70d1b202a5c2206575c7e4df6
https://doi.org/10.1016/j.bbrc.2006.12.060
https://doi.org/10.1016/j.bbrc.2006.12.060
Publikováno v:
Journal of Pharmaceutical Sciences. 89:751-757
We investigated the binding of propranolol (PL), disopyramide (DP), and verapamil (VP) enantiomers by human α 1 ‐acid glycoprotein (AGP; also called orosomucoid) and the relationships between the extent of drug binding and lipophilicity, desialyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a315f9b2fc201406169552fadc68806
https://doi.org/10.1002/(sici)1520-6017(200006)89:6<751::aid-jps6>3.0.co
https://doi.org/10.1002/(sici)1520-6017(200006)89:6<751::aid-jps6>3.0.co
Autor:
Hideki Minematsu, Koichi Igarashi, Aiji Ohtsuka, Kazunori Oie, Toshitaka Oohashi, Masahiko Hirai, Takayuki Otani
Publikováno v:
Journal of electron microscopy. 60(1)
Active targeting of the liposome is an attractive strategy for drug delivery and in vivo bio-imaging. We previously reported the specific accumulation of Sialyl Lewis X (SLX) liposome to inflamed tissue in arthritic model mice or tumor-bearing mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff15602f716f58e89d72c081ac7fea03
https://pubmed.ncbi.nlm.nih.gov/20923872
https://pubmed.ncbi.nlm.nih.gov/20923872
Autor:
Yoshie Hiramatsu, Masaharu Seno, Yue Guang Li, Kazunori Oie, Koich Igarashi, Masahiko Hirai, Hideaki Wakita, Shinki Iwashita, Masashi Okada, Takayuki Otani, Ling Chen
Publikováno v:
Contrast Media & Molecular Imaging.
Generally angiogenic factors induce the expression of E-selectin in vascular endothelial cells in the tumors. In this study, we employed an anti-E-selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6742ded91318c4a4bba6735d1a08432
https://doi.org/10.1002/cmmi.367
https://doi.org/10.1002/cmmi.367
Autor:
Eisaku Kondo, Tadashi Yoshino, Masahiko Hirai, Masaki Adachi, Tomotsugu Ichikawa, Takehiro Tanaka, Ryuzo Ueda, Isao Date, Takayoshi Miyake, Akiyoshi Moriwaki, Kazuhiro Yoshikawa, Koichi Ichimura, Nobuya Ohara
Publikováno v:
Molecular cancer therapeutics. 7(6)
Molecular targeting agents have become formidable anticancer weapons, which show much promise against the refractory tumors. Functional peptides are among the more desirable of these nanobio-tools. Intracellular delivery of multiple functional peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc8164f8879fbac39a6770c04b997c1
https://pubmed.ncbi.nlm.nih.gov/18566217
https://pubmed.ncbi.nlm.nih.gov/18566217
Autor:
Masahiko Hirai, Masashi Okada, Masaharu Seno, Ling Chen, Takayuki Kudoh, Takafumi Nakano, Koichi Igarashi, Akifumi Mizutani, Yue-Guang Li
Publikováno v:
Molecular Cancer Therapeutics. 10:A118-A118
Introduction: Liposomes, a number of designs have been applied to confer them specific affinity to tumor sites, are considered as appropriate carriers to delivery anti-cancer agents to tumor sites so as to reduce side effects. Breast cancer is one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beda74a5bd7281659da4b91cf9f3b323
https://doi.org/10.1158/1535-7163.targ-11-a118
https://doi.org/10.1158/1535-7163.targ-11-a118