Výsledky vyhledávání - "Masahiko Ohtsuki"

Tissue distribution of humanized anti-human Fas monoclonal antibody (R-125224) based on fas antigen–antibody reaction in collagen-induced arthritis monkeys

Autor: Motoko Saito, Junichi Nakayama, Yukie Ogawa, Yasushi Yoshigae, Atsushi Kurihara, Masahiko Ohtsuki, Toshihiko Ikeda

Publikováno v: Life Sciences. 80:2005-2014

R-125224 is a novel humanized anti-human Fas monoclonal antibody prepared from HFE7A, which is a monoclonal mouse IgG anti-Fas antibody, by grafting the mouse complementarity-determining regions to human IgG, presently being developed as a drug for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a773bfab6a690ba2c0800ebf658ae3f2
https://doi.org/10.1016/j.lfs.2007.02.043

Zobrazit plný text záznamu

In SCID Mice with Transplanted Joint Tissues from Rheumatism Patients, a Model Mice of Human Rheumatoid Arthritis, Anti-human Fas Antibody (R-125224) Distributes Specifically to Human Synovium

Autor: Motoko Saito, Yasushi Yoshigae, Toshihiko Ikeda, Atsushi Kurihara, Junichi Nakayama, Yukie Ogawa, Masahiko Ohtsuki

Publikováno v: Pharmaceutical Research. 24:310-317

We investigated the tissue distribution of a humanized anti-human Fas monoclonal antibody, R-125224, in SCID mice transplanted with synovial tissues from patients with rheumatoid arthritis (SCID-HuRAg mice). The binding kinetics of R-125224 was also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0509a6a7d3c9948d9d57db1d18175ad4
https://doi.org/10.1007/s11095-006-9148-5

Zobrazit plný text záznamu

Suppression of osteoclastogenesis in rheumatoid arthritis by induction of apoptosis in activated CD4+ T cells

Autor: Yoshiko Onozawa, Hiroaki Matsuno, Miwa Uzuki, Akiko Yonemura, Takashi Sawai, Masahiko Ohtsuki, Tomoatsu Kimura, Junichi Nakayama, Yukie Ogawa

Publikováno v: Arthritis & Rheumatism. 48:3350-3358

Objective To examine the suppressive effect of anti-human Fas monoclonal antibody (mAb) on osteoclastogenesis in rheumatoid arthritis (RA) both in vitro and in vivo. Methods For in vitro analysis, activated CD4+ T cells derived from peripheral blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe357b3a5bca3c8cbf6cebfa3e10f557
https://doi.org/10.1002/art.11322

Zobrazit plný text záznamu

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

Publikováno v: Nature Genetics. 35:341-348

Rheumatoid arthritis is a common inflammatory disease with complex genetic components. We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to susceptibility to rheumatoid arthritis in the Japanese population by ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489eaa95296546360d051a96acf6aa2a
https://doi.org/10.1038/ng1267

Zobrazit plný text záznamu

Therapeutic Effect of Novel Anti-Human Fas Antibody HFE7A on Graft-versus-Host Disease Model

Autor: Yoshio Tani, Akio Shiraishi, Masahiko Ohtsuki, Harumi Kuwahara, Yukie Ogawa, Yasuhiro Takaichi

Publikováno v: Clinical Immunology. 99:340-346

In order to evaluate anti-human Fas antibody, we have established a new graft-versus-host disease (GVHD) model wherein splenocytes of human Fas transgenic mice (hFas-TgM) were transferred to immune-deficient SCID mice. In this model, although host SC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8504e26c4343e17bd29c0a0566d13021
https://doi.org/10.1006/clim.2001.5028

Zobrazit plný text záznamu

A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity

Autor: Junko Yamaguchi, Hiroko Yoshida-Kato, Shu Takahashi, Akio Shiraishi, Nobufusa Serizawa, Jun Ohsumi, Kusuki Nishioka, Yoshiro Tani, Masahiko Ohtsuki, Mayumi Watanabe, Shin Yonehara, Kimihisa Ichikawa

Publikováno v: International Immunology. 12:555-562

Defects in Fas-mediated apoptosis are implicated in autoimmune diseases including rheumatoid arthritis (RA). Although induction of Fas-mediated apoptosis could have therapeutic effects on these diseases, it might cause deleterious effects in liver as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28ef87d45b7e4710c13ef9d37e53a4f
https://doi.org/10.1093/intimm/12.4.555

Zobrazit plný text záznamu

TGF-β receptors

Autor: Liliana Attisano, Fernando López-Casillas, Jeffrey L. Wrana, Sela Cheifetz, Joan Massagué, Masahiko Ohtsuki, Janet L. Andres

Publikováno v: Molecular Reproduction and Development. 32:99-104

The nature and role of cell surface proteins that bind members of the TGF-beta family has been investigated. TGF-beta, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF-beta system, these receptors are impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5936c9fd28c5ce4ce9e1f2226b6b3bc
https://doi.org/10.1002/mrd.1080320204

Zobrazit plný text záznamu

Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction

Autor: Masahiko Ohtsuki, Joan Massagué

Publikováno v: Molecular and Cellular Biology. 12:261-265

Transforming growth factor-beta 1 (TGF-beta 1) rapidly increases the expression of junB transcription factor and plasminogen activator inhibitor-1 (PAI-1) and prevents the cell cycle-dependent phosphorylation of the RB retinoblastoma susceptibility g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2751e7599a7abd11081ce2a04b815766
https://doi.org/10.1128/mcb.12.1.261

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání