Methylmercury toxic mechanism related to protein degradation and chemokine transcription

Autor: Jin-Yong Lee, Gi-Wook Hwang, Akira Naganuma, Masahiko Satoh

Publikováno v: Environmental Health and Preventive Medicine, Vol 25, Iss 1, Pp 1-5 (2020)

Abstract Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing t

Externí odkaz: https://doaj.org/article/3ec088acecc04c94acbe8e792c0cacd3

Cadmium Toxicity Is Regulated by Peroxisome Proliferator-Activated Receptor δ in Human Proximal Tubular Cells

Autor: Chikage, Mori, Jin-Yong, Lee, Maki, Tokumoto, Masahiko, Satoh

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8652

Cadmium (Cd) is a toxic heavy metal that is widely present in the environment. Renal proximal tubule disorder is the main symptom of Cd chronic poisoning. Our previous study demonstrated that Cd inhibits the total activities of peroxisome proliferato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092016902a0a715c829902ee7f5bccee

Time-Dependent Changes in the Gene Expression Levels in the Mouse Kidney by Long-Term Exposure to Cadmium

Autor: Maki Tokumoto, Chikage Mori, Jin-Yong Lee, Masahiko Satoh

Publikováno v: BPB Reports. 4:69-73

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ad1a0a9e18adf9c99481159e6829eb3
https://doi.org/10.1248/bpbreports.4.2_69

Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression

Autor: Jin-Yong Lee, Maki Tokumoto, Gi-Wook Hwang, Min-Seok Kim, Tsutomu Takahashi, Akira Naganuma, Minoru Yoshida, Masahiko Satoh

Publikováno v: Toxics, Vol 6, Iss 3, p 48 (2018)

Mercury compounds are known to cause central nervous system disorders; however the detailed molecular mechanisms of their actions remain unclear. Methylmercury increases the expression of several chemokine genes, specifically in the brain, while meta

Externí odkaz: https://doaj.org/article/1c1798137cc14c6db2000c7d55de8a74

A Novel In Vitro Assay Using Human iPSC-Derived Sensory Neurons to Evaluate the Effects of External Chemicals on Neuronal Morphology: Possible Implications in the Prediction of Abnormal Skin Sensation

Autor: Mitsutoshi Tominaga, Sumika Toyama, Shinya Kondo, Yayoi Kamata, Tamie Suzuki, Tetsuhito Sakurai, Masahiko Satoh, Yasushi Suga, Kenji Takamori

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10525, p 10525 (2021)

Neuronal morphological changes in the epidermis are considered to be one of causes of abnormal skin sensations in dry skin-based skin diseases. The present study aimed to develop an in vitro model optimised for human skin to test the external factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd57dd355756cba2e7b2a3b5ba31586
https://pubmed.ncbi.nlm.nih.gov/34638865