Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Masahiko, Horiba"'
Publikováno v:
The Journal of Organic Chemistry. 88:154-162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0053c2d655ae873db6259172d542cd9
https://doi.org/10.1021/acs.joc.2c02038
https://doi.org/10.1021/acs.joc.2c02038
Publikováno v:
Bioorganic & Medicinal Chemistry. 46:116359
We describe herein the design and synthesis of 4′-C,5′-C-methylene-bridged nucleic acid (4′,5′-BNA), a novel artificial nucleic acid with the torsion angle γ in a non-canonical +ac range. The 4′,5′-BNA phosphoramidite bearing a thymine n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c296e2a0449bed8c7e8cf44a88704d6
https://doi.org/10.1016/j.bmc.2021.116359
https://doi.org/10.1016/j.bmc.2021.116359
Publikováno v:
The Journal of organic chemistry. 85(4)
Ethynylphosphonate (EP)-linked thymidine dimers were synthesized via a palladium-catalyzed cross-coupling reaction and successfully incorporated into oligonucleotides. The oligonucleotides containing EP linkages appropriately formed a duplex with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef48eb3ef12ed1f546d2908ecd050511
https://pubmed.ncbi.nlm.nih.gov/31867976
https://pubmed.ncbi.nlm.nih.gov/31867976
Publikováno v:
The Journal of Organic Chemistry. 81:11000-11008
We previously reported the synthesis and evaluation of 2′-O,4′-C-spirocyclopropylene-bridged nucleic acid (scpBNA) bearing a thymine (T) nucleobase. Oligonucleotides (ONs) modified with scpBNA-T exhibited strong binding affinity to complementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3bdcf3523ea9a232d7a8e073594d3b4
https://doi.org/10.1021/acs.joc.6b02036
https://doi.org/10.1021/acs.joc.6b02036
Autor:
Hiroshi Aoyama, Satoshi Obika, Masahiko Horiba, Takao Yamaguchi, Takaki Habuchi, Kosuke Ramon Ito
Publikováno v:
The Journal of organic chemistry. 84(3)
Oligonucleotides modified with 2′-O,4′-C-spirocyclopropylene-bridged nucleic acid (scpBNA) exhibit excellent duplex-forming ability with their complementary single-stranded RNA (ssRNA). Here, we demonstrate that scpBNA bearing a 2-thiothymine (sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253c3f714a01aa1476f1588e9fb1ff5b
https://pubmed.ncbi.nlm.nih.gov/30632750
https://pubmed.ncbi.nlm.nih.gov/30632750
Publikováno v:
The Journal of organic chemistry. 81(22)
We previously reported the synthesis and evaluation of 2'-O,4'-C-spirocyclopropylene-bridged nucleic acid (scpBNA) bearing a thymine (T) nucleobase. Oligonucleotides (ONs) modified with scpBNA-T exhibited strong binding affinity to complementary sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4051bc417a5970a8cf75c64fadf849f3
https://pubmed.ncbi.nlm.nih.gov/27779877
https://pubmed.ncbi.nlm.nih.gov/27779877
Publikováno v:
Chemical communications (Cambridge, England). 51(47)
2′-O,4′-C-Spirocyclopropylene bridged nucleic acid (scpBNA), an analogue of 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA/LNA) bearing a cyclopropane ring at the 6′-position, was synthesized and successfully incorporated into olig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158974a56183f606ce9313de3a471bc1
https://pubmed.ncbi.nlm.nih.gov/25985928
https://pubmed.ncbi.nlm.nih.gov/25985928
Autor:
Masakazu Dohi, Sawako Wakita, Yoshiyuki Hari, Han Kim, Yuka Hitomi, Satoshi Obika, Masahiko Horiba, Yuta Ito, Takashi Osawa
Publikováno v:
HETEROCYCLES. 97:306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7322b4b83f4e799d9561f391d2cad5e7
https://doi.org/10.3987/com-18-s(t)20
https://doi.org/10.3987/com-18-s(t)20
Publikováno v:
Journal of Organic Chemistry; 11/18/2016, Vol. 81 Issue 22, p11000-11008, 9p