Výsledky vyhledávání - "Masahide Toshima"

Gastrointestinal toxicities of 5-fluorouracil increase the proportion of regulatory T cells in intestinal tract: advantages of alternate-day S-1 administration

Autor: Masahide Toshima, Koh Miura, Atsushi Kohyama, Toshihiro Komura, Taiki Kajiwara, Katsuyoshi Kudoh, Michiaki Unno, Shinobu Ohnuma, Sho Haneda, Miki Shimada, Takeshi Naitoh, Hiroaki Musha, Tetsuhiko Shirasaka

Publikováno v: International Journal of Clinical Oncology. 20:913-921

5-Fluorouracil (5-FU), a core anticancer agent for malignancies, induces gastrointestinal (GI) toxicities. Despite recent advances in tumor immunology, it still remains unknown how GI toxicities affect antitumor immunity. S-1 is a tegafur-based oral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1662ceec3b0391e1166d90056a3787ec
https://doi.org/10.1007/s10147-015-0791-x

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IL-23 directly enhances the proliferative and invasive activities of colorectal carcinoma

Autor: Kazuhiro Watanabe, Chikashi Shibata, Hitoshi Ogawa, Sho Haneda, Taiki Kajiwara, Toshihiro Komura, Hideyuki Suzuki, Shinobu Ohnuma, Tomohiko Sase, Iwao Sasaki, Hiroyuki Sasaki, Masahide Toshima, Koh Miura, Shunichi Kimura, Yasufumi Matsuda

Publikováno v: Oncology Letters. 4:199-204

Interleukin-23 (IL-23) plays an essential role in the mucosal immune system. It has been suggested that IL-23 is able to induce carcinogenesis as well as inflammation and a recent study revealed that IL-23R is expressed in colorectal carcinoma cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e39cf686fa577b25d1e61a748f34e3
https://doi.org/10.3892/ol.2012.739

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Young-onset peri-anorectal leiomyomatosis: report of a case

Autor: Chikashi Shibata, Koh Miura, Masahide Toshima, Yoshifumi Matsuda, Hitoshi Ogawa, Taiki Kajiwara, Sho Haneda, Hiroyuki Sasaki, Iwao Sasaki, Tomohiko Sase, Kazuhiro Watanabe, Takeshi Naitoh, Kazuyuki Ishida, Shinobu Ohnuma, Takayuki Mizoi

Publikováno v: Surgery Today. 43:329-334

A 23-year-old female was referred with constipation that lasted for 2 years. Preoperative examinations revealed multiple submucosal tumors beside the anorectum, along with subcutaneous tumors in the left buttock. The pathological diagnosis was leiomy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913e70b6a69e47f71c1fcb56a80c9e67
https://doi.org/10.1007/s00595-012-0201-1

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Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects

Autor: Masahide Toshima, Takeshi Naitoh, Hiroaki Musha, Toshihiro Komura, Atsushi Kohyama, Koh Miura, Taiki Kajiwara, Miki Shimada, Fumiyoshi Fujishima, Alex Philchenkov, Kei Nakagawa, Sho Haneda, Michiaki Unno, Katsuyoshi Kudoh, Tetsuhiko Shirasaka, Shinobu Ohnuma, Chikashi Shibata

Publikováno v: International journal of clinical oncology. 20(1)

A clinical trial of S-1 with leucovorin (S-1/LV) in metastatic colorectal cancer (CRC) patients demonstrated promising efficacy; however, the gastrointestinal toxicities were so severe that it has not been applied in the clinical setting. On the othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1502aaab3d86efc2563046162ffcc633
https://pubmed.ncbi.nlm.nih.gov/24802097

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Abstract 631: Gastrointestinal toxicities of 5-FU increase the proportion of regulatory T cells in murine intestinal tract: Advantages of alternate-day S-1 administration

Autor: Shinobu Ohnuma, Sho Haneda, Takeshi Naitoh, Hiroaki Musha, Katsuyoshi Kudoh, Koh Miura, Tetsuhiko Shirasaka, Fuyuhiko Motoi, Michiaki Unno, Toshihiro Komura, Taiki Kajiwara, Yu Katayose, Masahide Toshima, Atsushi Kohyama

Publikováno v: Cancer Research. 74:631-631

[Introduction] 5-fluorouracil (5-FU), a core anticancer agent used for various malignancies, induces gastrointestinal (GI) toxicities. The tegafur-based oral 5-FU prodrug S-1 is recognized to be a key drug for GI and other malignancies in Japan and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7293048a29f458aa4c6755b96f752b70
https://doi.org/10.1158/1538-7445.am2014-631

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Abstract 792: Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: A shorter drug-free interval leads to more efficient antitumor effects

Autor: Masahide Toshima, Shinobu Ohnuma, Sho Haneda, Koh Miura, Katsuyoshi Kudoh, Michiaki Unno, Taiki Kajiwara, Yu Katayose, Takeshi Naitoh, Hiroaki Musha, Tetsuhiko Shirasaka, Toshihiro Komura, Atsushi Kohyama

Publikováno v: Cancer Research. 74:792-792

[Background] A clinical trial of S-1 with leucovorin (S-1/LV) in metastatic colorectal cancer (CRC) patients demonstrated promising efficacy; however, the gastrointestinal toxicities were so severe that it has not been applied in the clinical setting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4388f97e5ea5fb2e7f8d8907d8a8a43
https://doi.org/10.1158/1538-7445.am2014-792

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Abstract 2832: Single nucleotide polymorphisms of DPYD and MTHFR predict adverse events associated with 5-fluorouracil in patients with gastrointestinal cancer

Autor: Atsushi Kohyama, Michiiro Tanaka, Sho Haneda, Katsuyoshi Kudoh, Toshihiro Komura, Koh Miura, Masahide Toshima, Wataru Fujibuchi, Shinobu Ohnuma, Taiki Kajiwara, Takeshi Naitoh, Hiroaki Musha, Michiaki Unno

Publikováno v: Cancer Research. 74:2832-2832

Purpose The aim of this study was to investigate the association between 5-fluorouracil (5-FU)-related adverse events (AEs) in Japanese patients with gastrointestinal cancer treated with 5-FU and the patient genotypes DPYD, MTHFR, OPRT, and TYMS. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::555e0ee2c87f0eac68f064b574dc85ec
https://doi.org/10.1158/1538-7445.am2014-2832

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