Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Masahide Tone"'
Autor:
Shlomo Melmed, Hiraku Kameda, Anat Ben-Shlomo, Shozo Yamada, Masaaki Yamamoto, Yasuhiko Kawakami, Akira Takeshita, Masahide Tone, Masato Yamamoto, Yukiko Tone, Takako Araki
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Mechanisms underlying pituitary corticotroph adenoma adrenocorticotropin (ACTH) production are poorly understood, yet circulating ACTH levels closely correlate with adenoma phenotype and clinical outcomes. Objective We characterized the 5′
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e8c99b5cce533451e8f4711f70c4b3
https://doi.org/10.1210/clinem/dgab387
https://doi.org/10.1210/clinem/dgab387
Publikováno v:
Endocrinology. 160:276-291
Because an acidic cellular microenvironment is engendered by inflammation and may determine cell differentiation, we elucidated the impact of acidic conditions on induction of proopiomelanocortin (POMC) expression. Here, we demonstrate mechanisms for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16cc3c6d69615e6855d7a9a18bbf0f7
https://doi.org/10.1210/en.2018-00920
https://doi.org/10.1210/en.2018-00920
Autor:
Masahide Tone, Yukiko Tone, Xiaohai Liu, Takako Araki, Shlomo Melmed, Hiraku Kameda, Hidenori Fukuoka
Publikováno v:
Journal of the Endocrine Society
The epidermal growth factor receptor (EGFR), expressed in adrenocorticotrophic hormone (ACTH)–secreting pituitary adenomas causing Cushing disease, regulates ACTH production and corticotroph proliferation. To elucidate the utility of EGFR as a ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6622335cbf4d724452ddc00683f35f
https://doi.org/10.1210/js.2016-1053
https://doi.org/10.1210/js.2016-1053
Autor:
Daniel Cuevas-Ramos, Takako Araki, Yukiko Tone, Ning-Ai Liu, Shlomo Melmed, Roy Heltsley, Masahide Tone
Publikováno v:
Endocrine-Related Cancer. 23:857-870
Cushing’s syndrome is caused by excessive adrenocorticotropic hormone (ACTH) secretion derived from pituitary corticotroph tumors (Cushing disease) or from non-pituitary tumors (ectopic Cushing’s syndrome). Hypercortisolemic features of ectopic C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef308389d3fd64457d9a7550f2421a6
https://doi.org/10.1530/erc-16-0206
https://doi.org/10.1530/erc-16-0206
Autor:
Takako Araki, Yukiko Tone, Masaaki Yamamoto, Hiraku Kameda, Ben-Shlomo, Anat, Shozo Yamada, Akira Takeshita, Masato Yamamoto, Yasuhiko Kawakami, Masahide Tone, Shlomo Melmed, Araki, Takako, Tone, Yukiko, Yamamoto, Masaaki, Kameda, Hiraku, Yamada, Shozo, Takeshita, Akira, Yamamoto, Masato, Kawakami, Yasuhiko, Tone, Masahide
Publikováno v:
Journal of Clinical Endocrinology & Metabolism; Sep2021, Vol. 106 Issue 9, pe3346-e3363, 18p
Autor:
Masahide Tone, Daniel Cuevas-Ramos, Shlomo Melmed, Ning-Ai Liu, Anat Ben-Shlomo, Takako Araki, Jiang Hong, Yukiko Tone
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 100:2557-2564
Cushing disease, due to pituitary corticotroph tumor ACTH hypersecretion, drives excess adrenal cortisol production with adverse morbidity and mortality. Loss of glucocorticoid negative feedback on the hypothalamic-pituitary-adrenal axis leads to aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed5445163bcae50ed1838fa1db80f1f
https://doi.org/10.1210/jc.2015-1606
https://doi.org/10.1210/jc.2015-1606
Autor:
Masahide Tone, Yukiko Tone, Yoshiko Nagaoka, Andra Stefania Necula, Chihiro Ogawa, Masato Tsuda, Herman Waldmann, Duncan Howie, Esteban Masuda, Makoto Katsumata
Publikováno v:
Frontiers in Immunology
The transcription factor FOXP3 plays key roles in the development and function of regulatory T cells (Treg) capable of preventing and correcting immunopathology. There has been much interest in exploiting Treg as adoptive cell therapy in man, but iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d65f924297adcde8e099a343ab0d11
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Kathleen F. Nolan, Jennifer M. Babik, Catherine Raven, Sara A. J. Thompson, Yukiko Tone, Herman Waldmann, Masahide Tone
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of p35 and p40 subunits and is required for induction of T helper 1 (Th1) responses. Knowledge of how the IL-12 gene is regulated will permit an understanding of susceptibility and resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a662789c1605294626874f780da8f02
https://ora.ox.ac.uk/objects/uuid:b3595da1-0f0d-42b3-a467-d63f18937f82
https://ora.ox.ac.uk/objects/uuid:b3595da1-0f0d-42b3-a467-d63f18937f82
We have isolated the CD59 gene from human genomic libraries. The gene is distributed over more than 27 × 10 3 base-pairs and consists of one 5′-untranslated exon and three coding exons. The gene structure is similar to that of mouse Ly-6 with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c625f2a65b21b3e8eadbe102bca8cc4
https://ora.ox.ac.uk/objects/uuid:dda4f595-10da-4db4-9b12-3ee78a58b155
https://ora.ox.ac.uk/objects/uuid:dda4f595-10da-4db4-9b12-3ee78a58b155