Výsledky vyhledávání - "Masaharu Kanaoka"

Comparison of gene expression changes induced by biguanides in db/db mice liver

Autor: Toru Kimura, Hironori Ishikawa, Masaharu Kanaoka, Koji Hayashi, Takao Kawamura, Mutsuo Taiji, Junji Ichihara, Masayuki Heishi

Publikováno v: The Journal of Toxicological Sciences. 33:339-347

Large-scale clinical studies have shown that the biguanide drug metformin, widely used for type 2 diabetes, to be very safe. By contrast, another biguanide, phenformin, has been withdrawn from major markets because of a high incidence of serious adve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e545246c56e132b516af524b4b6b78
https://doi.org/10.2131/jts.33.339

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Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453

Autor: Tomitake Tsukihara, Masaharu Kanaoka, Tetsuya Kohno, Hitoshi Hochigai, Eiki Yamashita

Publikováno v: Biochemical and Biophysical Research Communications. 344:315-322

Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453 have been solved at 2.01 and 2.37A resolutions, respectively. The results revealed that the binding modes f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb099afa593735fecc94c23f201a707
https://doi.org/10.1016/j.bbrc.2006.03.098

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Computational prediction of the plasma protein‐binding percent of diverse pharmaceutical compounds

Autor: Masaharu Kanaoka, Kazuto Yamazaki

Publikováno v: Journal of Pharmaceutical Sciences. 93:1480-1494

A nonlinear regression analysis has been applied to develop a new method to predict the plasma protein-binding percent of structurally diverse pharmaceutical compounds. The analysis included over 300 launched drugs with experimental human plasma prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4655a1cc2dd033eacc6085c3810baf16
https://doi.org/10.1002/jps.20059

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Proteomic analysis of rat heart in ischemia and ischemia-reperfusion using fluorescence two-dimensional difference gel electrophoresis

Autor: Hideshi Satoh, Jun Sakai, Masaharu Kanaoka, Shinichi Kojima, Hironori Ishikawa, Setsuko Yamamoto

Publikováno v: PROTEOMICS. 3:1318-1324

Ischemia-reperfusion injury is a major complication occurring in acute myocardial infarction, cardiopulmonary bypass surgery, and heart transplantation. The aim of this study was to identify proteins that were involved in ischemia-reperfusion injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47a2049c0c23b2983d0ea60159b8b50
https://doi.org/10.1002/pmic.200300432

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Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues

Autor: Hirohiko Hasegawa, Masaharu Kanaoka, Kazuto Yamazaki, Yasuyuki Ueki, Kayo Umekawa, Naohito Ohashi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:1275-1278

A novel non-peptidyl endothelin converting enzyme inhibitor was obtained through a pharmacophore analysis of known inhibitors and three-dimensional structure database search. Analogues of the new inhibitor were designed using the structure-activity r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1dc72c8b7adc928e9422fd60d06496
https://doi.org/10.1016/s0960-894x(02)00149-x

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D1 cap region involved in the receptor recognition and neural cell survival activity of human ciliary neurotrophic factor

Autor: Masaharu Kanaoka, Chikao Nakayama, Toru Kimura, Makoto Inoue, Kaoru Kikuchi, Hiroshi Noguchi, Akira Ito, Yohko Ishige

Publikováno v: Proceedings of the National Academy of Sciences. 92:8579-8583

Human ciliary neurotrophic factor (hCNTF), which promotes the cell survival and differentiation of motor and other neurons, is a protein belonging structurally to the alpha-helical cytokine family. hCNTF was subjected to three-dimensional structure m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a343c609e1cf2837323640e05e8c885e
https://doi.org/10.1073/pnas.92.19.8579

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Have The Lessons Learned from The Asian Financial Crisis Been Applied Effectively in Asian Economies?

Autor: Masaharu Kanaoka

Publikováno v: International Journal of Economics and Finance. 4

To improve the quality of economic managements, this paper attempts to determine whether the lessons of the 1997 Asian financial crisis were effectively applied in Asian economies in the mid-2000s and whether the application mitigated the shocks of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb11efe0c8f781eeba83883d8836c054
https://doi.org/10.5539/ijef.v4n2p103

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Molecular dynamics simulation of winter flounder antifreeze protein variants in solution: correlation between side chain spacing and ice lattice

Autor: M. Mori, Y. Kikuzono, Masaharu Kanaoka, H. Jorgensen, Y. Yabusaki, H. Matsui, H. Yanagi

Publikováno v: "Protein Engineering, Design and Selection". 6:19-27

The solution structure of the 38 amino acid C-terminal region of the precursor for the HPLC-6 antifreeze protein from winter flounder has been investigated with molecular dynamics using the AMBER software. The simulation for the peptide in aqueous so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941f8a3c79d4d87c2e6611508ff4bae5
https://doi.org/10.1093/protein/6.1.19

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