Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn's Disease

Autor: Kenji Watanabe, Takayuki Matsumoto, Tadakazu Hisamatsu, Hiroshi Nakase, Satoshi Motoya, Naoki Yoshimura, Tetsuya Ishida, Shingo Kato, Tomoo Nakagawa, Motohiro Esaki, Masakazu Nagahori, Toshiyuki Matsui, Yuji Naito, Takanori Kanai, Yasuo Suzuki, Masanori Nojima, Mamoru Watanabe, Toshifumi Hibi, Akira Andoh, Toshifumi Ashida, Katsuya Endo, Yutaka Endo, Hiroshi Fujita, Mikihiro Fujiya, Ken Haruma, Sakiko Hiraoka, Ichiro Hirata, Yutaka Honda, Hideki Iijima, Bunei Iizuka, Kentaro Ikeya, Takuya Inoue, Syuji Inoue, Yo Ishiguro, Shyunji Ishihara, Hiroaki Ito, Ryuichi Iwakiri, Takashi Kagaya, Hiroshi Kashida, Jun Kato, Takehiko Katsurada, Fukunori Kinjyo, Kiyonori Kobayashi, Mayumi Kodama, Reiko Kunisaki, Koichi Kurahara, Takafumi Kurokami, Lee Kyouwon, Koichiro Matsuda, Kazuhiro Matsueda, Keiichi Mitsuyama, Yuji Mizokami, Shiro Nakamura, Masafumi Nomura, Atsuhiro Ogawa, Kazuichi Okazaki, Kazuaki Otsuka, Hirotake Sakuraba, Masayuki Saruta, Makoto Sasaki, Takayuki Shirai, Tomoaki Suga, Kazuhito Sugimura, Toshiro Sugiyama, Fuminao Takeshima, Hiroyuki Tamaki, Shinji Tanaka, Satoshi Tanida, Keiichi Tominaga, Taku Tomizawa, Kenji Watababe, Syojiro Yamamoto, Masaki Yamashita, Atsushi Yoshida

Publikováno v: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 16(4)

Background & Aims We previously reported results from a prospective randomized controlled trial comparing the efficacy of adalimumab monotherapy versus combination with azathioprine for patients with Crohn's disease (CD) who were naive to biologics a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3818adc19dc7ade8064669f47f7ad6
https://pubmed.ncbi.nlm.nih.gov/29104132

Histologically confirmed case of cerebral vasculitis associated with Crohn's disease--a case report

Autor: Taku Sugiyama, Hiroshi Nishihara, Yasutaka Kato, Katsuyuki Asaoka, Masafumi Nomura, Masayuki Gekka

Publikováno v: BMC Neurology

Background Extraintestinal manifestations in Crohn’s disease (CD) are frequent and well recognized. However, neurological involvement secondary to CD is rare, and there have been few histologically confirmed cases of cerebral vasculitis secondary t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac83fb2b103234afeefb62ce9fb98743
https://pubmed.ncbi.nlm.nih.gov/26390922

Effect of Ecabet Sodium Enema on mildly to moderately active ulcerative proctosigmoiditis: an open-label study

Autor: Yutaka Kohgo, Shinichi Kasai, Toru Kono, Masafumi Nomura

Publikováno v: The American Journal of Gastroenterology. 96:793-797

Ecabet sodium (ES), a nonabsorbable antigastric ulcer agent, has been shown to adhere to the region of an ulcer. It topically enhances gastric mucosal defensive factors such as the endogenous prostaglandins, capsaicin-sensitive sensory nerves, nitric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca7f45d9413fda4bb702374513c02dd
https://doi.org/10.1111/j.1572-0241.2001.03624.x

Invasion depth diagnosis of depressed type early colorectal cancers by combined use of videoendoscopy and chromoendoscopy

Autor: Tokiyoshi Ayabe, Yutaka Orii, Masato Taniguchi, Masaki Taruishi, Masafumi Nomura, Yutaka Kohgo, Toshifumi Ashida, Jiro Watari, Takeshi Obara, Yusuke Saitoh

Publikováno v: Gastrointestinal Endoscopy. 48:362-370

Background: Depressed type early colorectal cancers are found less frequently than other polypoid cancers although they have a higher submucosal invasion rate. Recently videocolonoscopy and chromoendoscopy have become available and precise descriptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::152ac588d5f23650558a3d33b55eb3d1
https://doi.org/10.1016/s0016-5107(98)70004-5

High enantiocontrol of michael additions by use of 2:2-dimethyloxazolidine chiral auxiliaries. Exclusively ul,lk-1,4-inductive michael additions of the lithium (z)-enolate of (s)-4-benzyl-2,2,5,5-tetramethyl-3-propanoyl-oxazolidine to α,β-unsaturated esters

Autor: Shuji Kanemasa, Hidetoshi Yamamoto, Masafumi Nomura, Sachiyo Yoshinaga

Publikováno v: Tetrahedron. 51:10463-10476

The lithium (Z)-enolate generated from the propanamide of (S)-4-benzyl-2,2,5,5-tetra-methyloxazolidine undergoes highly lk-1,4/anti-selective Michael additions to α,β-unsaturated ester and amide acceptors. However, only poor selectivities result wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a20c8f96453f4cfcd7429e335d83509c
https://doi.org/10.1016/0040-4020(95)00623-g