Acetylornithine aminotransferase TM1785 performs multiple functions in the hyperthermophile Thermotoga maritima

Autor: Masae Sekine, Kumiko Sakai-Kato, Yasuaki Saitoh, Masumi Katane, Hiroshi Homma, Tetsuya Miyamoto

Publikováno v: FEBS Letters. 595:2931-2941

The hyperthermophilic bacterium Thermotoga maritima peptidoglycan contains unusual d-lysine alongside typical d-alanine and d-glutamate. We previously identified lysine racemase and threonine dehydratase, but knowledge of d-amino acid metabolism rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad981c8c3b73626450a960c06eb70911
https://doi.org/10.1002/1873-3468.14222

Identification of an l-serine/l-threonine dehydratase with glutamate racemase activity in mammals

Autor: Kento Nakasako, Hiroshi Homma, Masumi Katane, Yasuaki Saitoh, Kanato Yako, Masae Sekine

Publikováno v: Biochemical Journal. 477:4221-4241

Recent investigations have shown that multiple d-amino acids are present in mammals and these compounds have distinctive physiological functions. Free d-glutamate is present in various mammalian tissues and cells and in particular, it is presumably c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bd5164ff717802ac382a701cb0239d
https://doi.org/10.1042/bcj20200721

Involvement of penicillin-binding proteins in the metabolism of a bacterial peptidoglycan containing a non-canonical d-amino acid

Autor: Hiroshi Homma, Yasuaki Saitoh, Masumi Katane, Tetsuya Miyamoto, Masae Sekine

Publikováno v: Amino Acids. 52:487-497

Bacteria produce various D-amino acids, including non-canonical D-amino acids, to adapt to environmental changes and overcome a variety of threats. These D-amino acids are largely utilized as components of peptidoglycan, and they promote peptidoglyca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15787fb3b7e4789e95012734609a2999
https://doi.org/10.1007/s00726-020-02830-7

YgeA is involved in L- and D-homoserine metabolism in Escherichia coli

Autor: Tetsuya Miyamoto, Yasuaki Saitoh, Masumi Katane, Masae Sekine, Hiroshi Homma

Publikováno v: FEMS Microbiology Letters. 369

Noncanonical D-amino acids are involved in peptidoglycan and biofilm metabolism in bacteria. Previously, we identified amino acid racemases with broad substrate specificity, including YgeA from Escherichia coli, which strongly prefers homoserine as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeaf50ab65a898b93574ca448d0eabd
https://doi.org/10.1093/femsle/fnac096

Dysfunctional D-aspartate metabolism in BTBR mouse model of idiopathic autism

Autor: Masae Sekine, Massimo Pasqualetti, Daniela Punzo, Alberto Galbusera, Masumi Katane, Francesco Errico, Hiroshi Homma, Tommaso Nuzzo, Mattia Miroballo, Alessandro Gozzi, Jean-Pierre Mothet, Alessandro Usiello, Yasuaki Saitoh

Publikováno v: Biochimica et Biophysica Acta Proteins and Proteomics
Biochimica et Biophysica Acta Proteins and Proteomics, 2020, 1868, ⟨10.1016/j.bbapap.2020.140531⟩
Biochimica et Biophysica Acta Proteins and Proteomics, Elsevier, 2020, 1868, ⟨10.1016/j.bbapap.2020.140531⟩
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics

Background Autism spectrum disorders (ASD) comprise a heterogeneous group of neurodevelopmental conditions characterized by impairment in social interaction, deviance in communication, and repetitive behaviors. Dysfunctional ionotropic NMDA and AMPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6427ec94099d3eab034bbfb2314c4e49
http://hdl.handle.net/11588/832261