Effects of M-1, a Major Metabolite of Sarpogrelate, on 5-HT-Induced Constriction of Isolated Human Internal Thoracic Artery

Autor: Naoko Tanaka-Totoribe, Eisaku Nakamura, Shuji Gamoh, Jun Tsunezumi, Masachika Kuwabara, Ryuichi Yamamoto, Atsuko Yokota, Muneaki Hidaka

Publikováno v: Biological and Pharmaceutical Bulletin. 43:1979-1982

Sarpogrelate, a selective 5-hydroxytryptamine (5-HT)2A receptor antagonist, inhibits 5-HT-induced platelet aggregation and vasoconstriction. It improves ischemic symptoms in patients with arteriosclerosis obliterans. M-1 is a major metabolite of sarp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d465c556755827cbf865974249f39d7
https://doi.org/10.1248/bpb.b20-00591

Cardiovascular Prognosis in Drug-Resistant Hypertension Stratified by 24-Hour Ambulatory Blood Pressure: The JAMP Study

Autor: Kazuomi Kario, Satoshi Hoshide, Keisuke Narita, Yukie Okawara, Hiroshi Kanegae, Kenji Aoki, Hajime Kihara, Toshiro Koga, Tomoaki Nakata, Kenji Oku, Yasufumi Matsuoka, Hiroaki Omori, Masafumi Nishizawa, Yasuo Tanno, Yoko Fukase, Koki Omi, Jun Takahashi, Hiroyuki Mizuno, Michiya Saito, Junichi Yatabe, Kazuo Eguchi, Kiyoshi Iwashita, Maki Kumada, Gaku Oki, Tomoyuki Kabutoya, Yukihiro Hojo, Masaru Ichida, Shizukiyo Ishikawa, Takahiro Komori, Yoshio Matsui, Masatoshi Matsumoto, Shoichiro Nagasaka, Masahiro Nakano, Yoshioki Nishimura, Kenta Okada, Kazuyuki Shimada, Masahisa Shimpo, Nozomu Takahashi, Hideyuki Uno, Joji Ishikawa, Toshio Kuroda, Nobutsune Hirahara, Yuta Kemi, Hisashi Yoshioka, Sakuo Hoshi, Atsuhi Mizuno, Kunihiko Ohno, Osamu Okazaki, Tsunehiro Saito, Tetsu Tanaka, Kazuo Yamashiro, Tatsuyuki Yamauchi, Shisei Yo, Shigeru Yomogita, Sayaka Hikita, Yasuhiro Kawase, Yoshifumi Nojiri, Yukihiro Sato, Kiyoshi Uchiba, Motoyuki Ishiguro, Atsushi Taguchi, Kazumasa Iida, Tatsuya Takemoto, Katsuyuki Tone, Hideyasu Abe, Yasuhisa Abe, Masami Hasegawa, Tomohiro Katsuya, Yoshiharu Okada, Shinichiro Tanaka, Genyo Tanke, Takeshi Takami, Jun Michiura, Masahiko Shiotani, Tomohiro Aoki, Koichi Ogura, Yuzuru Kawamura, Shigekiyo Nakanishi, Nobuo Sasaki, Toshiyuki Takahashi, Akihisa Fujii, Eiichiro Tanaka, Hiroyuki Katayama, Motoki Fukutomi, Kosuke Miyoshi, Hiroaki Naito, Sawa Yokota, Kazumasa Nakamura, Tetsu Yokota, Shinsuke Takasugi, Shuichiro Fujita, Yumiko Fujita, Hitoshi Kaneko, Takeshi Fujiwara, Wataru Kitamura, Yuhei Anan, Tomohiro Deguchi, Yuki Imaizumi, Jun Miyagi, Takahiro Tsuji, Yasuhiro Uchiwa, Shin Ueda, Takeya Yamaguchi, Tetsuro Yoshida, Ryo Yoshinaga, Kosuke Maeda, Kotaro Kunitomo, Kyousei Soda, Hirotoshi Baba, Keisuke Yonezu, Akihiro Hino, Genta Miura, Tomoko Nakamura, Munetoshi Kuroki, Fumihiko Omori, Toshiaki Hidaka, Takanori Hidaka, Yuichiro Yano, Yoshimasa Kanemaru, Michitaka Kitani, Masahiro Koga, Hirohide Kubo, Masachika Kuwabara, Junichi Miyata, Masahiko Nagata, Koji Sasaki, Noboru Tamaki, Hiroyasu Tasaka, Naoto Yokota, Takahiro Miyata, Eiyu Katsuren, Norifumi Kudeken, Noriharu Yagi

Publikováno v: Hypertension (Dallas, Tex. : 1979). 78(6)

Resistant hypertension is an important cardiovascular risk factor. This analysis of the JAMP study (Japan Ambulatory Blood Pressure Monitoring Prospective) data investigated the effects of uncontrolled resistant hypertension diagnosed using ambulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89451018ff49332da6401353c066ea8f
https://pubmed.ncbi.nlm.nih.gov/34719242

Diabetes Mellitus Induces Hyperreactivity of 5-Hydroxytryptamine (5-HT)-Induced Constriction in Human Internal Thoracic Artery and Is Associated with Increase in the Membrane Protein Level of 5-HT

Autor: Tatsuo, Shiba, Atsuko, Yokota, Shuji, Gamoh, Naoko, Tanaka-Totoribe, Masachika, Kuwabara, Eisaku, Nakamura, Takahiro, Hayase, Kunihide, Nakamura, Ryuichi, Yamamoto

Publikováno v: Biologicalpharmaceutical bulletin. 41(5)

Studies indicate that 5-hydroxytryptamine (5-HT) released from activated platelets in coronary artery bypass grafting (CABG) induces 5-HT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00f68d998ff9891ed6ea83bd6418d800
https://pubmed.ncbi.nlm.nih.gov/29434166

In patients with diabetes mellitus (DM), but not in patients without DM, angiotensin II is a vasospasm inducer in both venous and arterial conduits under coronary artery bypass grafting

Autor: Eisaku Nakamura, Atsuko Yokota, Ryuichi Yamamoto, Shuji Gamoh, Kunihide Nakamura, Tatsuo Shiba, Naoko Tanaka-Totoribe, Masachika Kuwabara, Takahiro Hayase, Hiroaki Hisa

Publikováno v: Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO2-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc552cfb5b483618924deec8d9b80428
https://doi.org/10.1254/jpssuppl.wcp2018.0_po2-3-7

Regional Differences in Hypertensive Cardiovascular Remodeling Between Fishing and Farming Communities in Japan

Autor: Yuichiro Yano, Takashi Inokuchi, Naoto Yokota, Kazuyuki Shimada, Noboru Tamaki, Masahiko Nagata, Satoshi Hoshide, Shuntaro Matsuda, Yoshimasa Kanemaru, Toshiaki Hidaka, Kazuomi Kario, Masachika Kuwabara

Publikováno v: American Journal of Hypertension. 24:437-443

BACKGROUND Effects of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) intake on the cardiovascular system have been reported, and thus we hypothesized that the prevalence of hypertensive cardiovascular remodeling would be lower in a fishing than a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab4c848fa6841316b9aa727619785e0
https://doi.org/10.1038/ajh.2010.263