Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Masabumi Shibuya"'
Autor:
Elin Sjöberg, Marit Melssen, Mark Richards, Yindi Ding, Catarina Chanoca, Dongying Chen, Emmanuel Nwadozi, Sagnik Pal, Dominic T. Love, Takeshi Ninchoji, Masabumi Shibuya, Michael Simons, Anna Dimberg, Lena Claesson-Welsh
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Endothelial phospholipase Cγ (PLCγ) is essential for vascular development; however, its role in healthy, mature, or pathological vessels is unexplored. Here, we show that PLCγ was prominently expressed in vessels of several human cancer forms, not
Externí odkaz:
https://doaj.org/article/7698f966a69a496bb790494d6f6061b0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract In normal pregnancy, the soluble form of FMS-like tyrosine kinase-1 (sFLT1)/ vascular endothelial growth factor receptor-1 (sVEGFR-1), a VEGF-trapping protein, is expressed in trophoblasts of the placenta, suggesting that it plays an importa
Externí odkaz:
https://doaj.org/article/f103add92e9944eba6418918b0bcc453
Autor:
Kyoko Hattori, Yoshiya Ito, Masako Honda, Kazuki Sekiguchi, Kanako Hosono, Masabumi Shibuya, Nobuya Unno, Masataka Majima
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 4, Pp 255-263 (2020)
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis. Endometrial fragments from wild-typ
Externí odkaz:
https://doaj.org/article/f2538156aa244ed3b772723679275ef5
Autor:
Tadashi Sasagawa, Atsushi Jinno-Oue, Takeshi Nagamatsu, Kazuki Morita, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Tomoyuki Fujii, Masabumi Shibuya
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly angiogenic and metastat
Externí odkaz:
https://doaj.org/article/d2e53d12dc934524b0e4c618be905489
Autor:
Kazuki Sekiguchi, Yoshiya Ito, Kyoko Hattori, Tomoyoshi Inoue, Kanako Hosono, Masako Honda, Akiko Numao, Hideki Amano, Masabumi Shibuya, Nobuya Unno, Masataka Majima
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Angiogenesis is critical in maintenance of endometrial tissues. Here, we examined the role of VEGF receptor 1 (VEGFR1) signaling in angiogenesis and tissue growth in an endometriosis model. Endometrial fragments were implanted into the perit
Externí odkaz:
https://doaj.org/article/53c1e7a7d61541b6bb4009a8327768e9
Autor:
Tomohiro Betto, Hideki Amano, Yoshiya Ito, Koji Eshima, Tsutomu Yoshida, Yoshio Matsui, Sakiko Yamane, Tomoyoshi Inoue, Fumisato Otaka, Kiyonori Kobayashi, Wasaburo Koizumi, Masabumi Shibuya, Masataka Majima
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 131-141 (2019)
Background: Ulcerative Colitis (UC) is an inflammatory bowel disease that affects the colon. The development of UC is regulated by immune cells. Previously, we showed that vascular endothelial growth factor receptor 1 (VEGFR1) tyrosine kinase (TK) si
Externí odkaz:
https://doaj.org/article/b2adeab5e4ee4c05a9cf74085f52511e
Autor:
Tsuyoshi Osawa, Teppei Shimamura, Kyoko Saito, Yoko Hasegawa, Naoko Ishii, Miyuki Nishida, Ritsuko Ando, Ayano Kondo, Muyassar Anwar, Rika Tsuchida, Shinjiro Hino, Akihisa Sakamoto, Kaori Igarashi, Kaori Saitoh, Keiko Kato, Keiko Endo, Shotaro Yamano, Yasuharu Kanki, Yoshihiro Matsumura, Takashi Minami, Toshiya Tanaka, Motonobu Anai, Youichiro Wada, Hideki Wanibuchi, Mitsuhiro Hayashi, Akinobu Hamada, Masayuki Yoshida, Shinichi Yachida, Mitsuyoshi Nakao, Juro Sakai, Hiroyuki Aburatani, Masabumi Shibuya, Kentaro Hanada, Satoru Miyano, Tomoyoshi Soga, Tatsuhiko Kodama
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 89-103.e7 (2019)
Summary: Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a common feature of aggressive cancer cells and can be targeted. However, metabolic alterations that support cancer cells upon nutrient starvation are
Externí odkaz:
https://doaj.org/article/c34c33e130784dc786b3ca3e8ed731d1
Autor:
Hideki Amano, Yoshio Mastui, Yoshiya Ito, Yusaku Shibata, Tomohiro Betto, Koji Eshima, Fumihiro Ogawa, Yukitoshi Satoh, Masabumi Shibuya, Masataka Majima
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 117, Iss , Pp - (2019)
Background: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with a poor prognosis. Fibroblast proliferation amplifies extracellular matrix deposition and increases angiogenesis. Vascular endothelial growth factor (VEGF) is one of the mos
Externí odkaz:
https://doaj.org/article/0ec1709ab47c41fd8f129847a4860c7b
Autor:
Hideyuki Kitahara, Sayaka Kajikawa, Yoko Ishii, Seiji Yamamoto, Takeru Hamashima, Erika Azuma, Hikari Sato, Takako Matsushima, Masabumi Shibuya, Yutaka Shimada, Masakiyo Sasahara
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 190-201 (2018)
Pericyte desorption from retinal blood vessels and subsequent vascular abnormalities are the pathogenesis of diabetic retinopathy (DR). Although the involvement of abnormal signals including platelet-derived growth factor receptor-β (PDGFRβ) and va
Externí odkaz:
https://doaj.org/article/b1b42ff4e43744cabfe57d68fdc1b0be
Autor:
Seiji Yamamoto, Masashi Muramatsu, Erika Azuma, Masashi Ikutani, Yoshinori Nagai, Hiroshi Sagara, Bon-Nyeo Koo, Satomi Kita, Erin O’Donnell, Tsuyoshi Osawa, Hiroyuki Takahashi, Ken-ichi Takano, Mitsuko Dohmoto, Michiya Sugimori, Isao Usui, Yasuhide Watanabe, Noboru Hatakeyama, Takahiro Iwamoto, Issei Komuro, Kiyoshi Takatsu, Kazuyuki Tobe, Shumpei Niida, Naoyuki Matsuda, Masabumi Shibuya, Masakiyo Sasahara
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood
Externí odkaz:
https://doaj.org/article/9aa3cc86afa343a8b1e09b837010f483