Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Masaaki Shibuya"'
Publikováno v:
FEBS Letters. 584:2258-2264
Triterpene saponins are a diverse group of compounds with a structure consisting of a triterpene aglycone and sugars. Identification of the sugar-transferase involved in triterpene saponin biosynthesis is difficult due to the structural complexity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7736daef2201bb3d670471c9cf69a03
https://doi.org/10.1016/j.febslet.2010.03.037
https://doi.org/10.1016/j.febslet.2010.03.037
Publikováno v:
Biochemical and Biophysical Research Communications. 391:899-902
Oxidosqualene:protostadienol cyclase (OSPC) from the fungus Aspergillus fumigatus, catalyzes the cyclization of (3S)-2,3-oxidosqualene into protosta-17(20)Z,24-dien-3beta-ol which is the precursor of the steroidal antibiotic helvolic acid. To shed li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fbb3bdc017a96dba55d61c1742422b
https://doi.org/10.1016/j.bbrc.2009.11.160
https://doi.org/10.1016/j.bbrc.2009.11.160
Autor:
Yasuyo Seshime, Masaaki Shibuya, Isao Fujii, Hisashi Mitsuguchi, Yutaka Ebizuka, Tetsuo Kushiro
Publikováno v:
Journal of the American Chemical Society. 131:6402-6411
Three putative oxidosqualene cyclase (OSC) genes exist in the genome of the fungus Aspergillus fumigatus that produces a steroidal antibiotic, helvolic acid. One of these genes, Afu4g14770, designated AfuOSC3, is clustered with genes of cytochrome P4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92cba911a4fcbcccf245bbd50f9a692
https://doi.org/10.1021/ja8095976
https://doi.org/10.1021/ja8095976
Publikováno v:
Organic Letters. 10:5071-5074
A new oxidosqualene cyclase (OSC) cDNA was cloned from the roots of Stevia rebaudiana. Functional expression in yeast and spectral analyses of the products established that the obtained OSC yields baccharis oxide as the major product. This is the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec22eca67ad59f935d339dc21a320684
https://doi.org/10.1021/ol802072y
https://doi.org/10.1021/ol802072y
Publikováno v:
Phytochemistry. 69:2559-2564
Ferns produce a variety of cyclic triterpene hydrocarbons in large amount. Squalene cyclases (SCs) are responsible enzymes for formation of cyclic triterpene hydrocarbon skeletons. Although more than ten bacterial SCs have been cloned and four of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68560c7ad15f376cdb50d0e3031b1d87
https://doi.org/10.1016/j.phytochem.2008.07.017
https://doi.org/10.1016/j.phytochem.2008.07.017
Publikováno v:
Journal of the American Chemical Society. 129:1450-1455
At1g78500, one of the oxidosqualene cyclase (OSC) homologues from Arabidopsis thaliana, was expressed in a lanosterol synthase-deficient yeast strain and the products were analyzed. In addition to the known triterpenes, this OSC was found to produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816893c0a81ab33be940ebe7e6127e75
https://doi.org/10.1021/ja066873w
https://doi.org/10.1021/ja066873w
Autor:
Masaaki Shibuya, Young-Hwa Kang, Yutaka Orihara, Pimpimon Tansakul, Hiroshi Saimaru, Yutaka Ebizuka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 55:784-788
Olive (Olea europaea) contains large quantity of triterpene acids including oleanolic acid (6) as a major one. Varieties of biological activities exhibited by triterpene acids attracted our attentions, especially from pharmaceutical viewpoints. Cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1071d0294482c41182d1b8041c71a7c6
https://doi.org/10.1248/cpb.55.784
https://doi.org/10.1248/cpb.55.784
Autor:
Mohammad Basyuni, Takafumi Okabe, Keichiro Oshiro, Shigeyuki Baba, Yutaka Ebizuka, Masaaki Shibuya, Masashi Inafuku, Hirosuke Oku, Hironori Iwasaki
Publikováno v:
Phytochemistry. 67:2517-2524
Homology based PCRs with degenerate primers designed from the conserved sequences among the known oxidosqualene cylases (OSCs) have resulted in cloning of a triterpene synthase (KcMS) from the young roots of Kandelia candel (L.) Druce (Rhizophoraceae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c375564aecdaa95478913c7cbbe13e9
https://doi.org/10.1016/j.phytochem.2006.09.016
https://doi.org/10.1016/j.phytochem.2006.09.016
Autor:
Takehiko Tsutsumi, Yutaka Ebizuka, Yuji Katsube, Ting Xiang, Hong Zhang, Kazuo Masuda, Masaaki Shibuya, Miyuki Otsuka
Publikováno v:
Organic Letters. 8:2835-2838
[structure: see text] Thirteen oxidosqualene cyclase homologues exist in the genome of Arabidopsis thaliana. One of these genes, At4g15340, was amplified by PCR and expressed in yeast. The yeast transformant accumulated tricyclic triterpene, (3S,13R)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a568cc82f57140cba6525f354817c2f
https://doi.org/10.1021/ol060973p
https://doi.org/10.1021/ol060973p
Autor:
Toshiya Muranaka, Ting Xiang, Kazuki Saito, Hikaru Seki, Yutaka Ebizuka, Masashi Suzuki, Tetsuo Kushiro, Kiyoshi Ohyama, Masaaki Shibuya, Hiroaki Hayashi, Yuji Katsube
Publikováno v:
Plant and Cell Physiology. 47:565-571
Sterols are important as structural components of plasma membranes and precursors of steroidal hormones in both animals and plants. Plant sterols show a wide structural variety and significant structural differences from those of animals. To elucidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bfe85224ebb2ce9eeec30e7f4c038d
https://doi.org/10.1093/pcp/pcj031
https://doi.org/10.1093/pcp/pcj031