Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Masaaki Sasaoka"'
Autor:
Takazumi Taniguchi, Ken-ichi Endo, Hidetoshi Tanioka, Masaaki Sasaoka, Kei Tashiro, Shigeru Kinoshita, Masaaki Kageyama
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Despite efficient and specific in vitro knockdown, more reliable and convenient methods for in vivo knockdown of target genes remain to be developed particularly for retinal research. Using commercially available and chemically modified siRN
Externí odkaz:
https://doaj.org/article/592188d10cff4b4fb91119369b563593
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217945 (2019)
Chemical proteasome inhibition has been a valuable animal model of neurodegeneration to uncover roles for the ubiquitin-proteasome system in the central nervous system. However, little is known about the effects of chemical proteasome inhibitors on r
Externí odkaz:
https://doaj.org/article/01134cb091324b34b02bac7a130f14e7
Autor:
Hidetoshi Tanioka, Takazumi Taniguchi, Kei Tashiro, Kenichi Endo, Masaaki Kageyama, Shigeru Kinoshita, Masaaki Sasaoka
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Despite efficient and specific in vitro knockdown, more reliable and convenient methods for in vivo knockdown of target genes remain to be developed particularly for retinal research. Using commercially available and chemically modified siRNA so-call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e912f4a37b6974d446a8593ccf14f1
https://doaj.org/article/592188d10cff4b4fb91119369b563593
https://doaj.org/article/592188d10cff4b4fb91119369b563593
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Rotenone, a mitochondrial complex I inhibitor, causes retinal degeneration via unknown mechanisms. To elucidate the molecular mechanisms of its action, we further characterized a rat model of rotenone-induced retinal degeneration. Intravitreal inject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf0a9478db7a779e23f9a36e0673f65
http://link.springer.com/article/10.1038/s41598-020-57638-y
http://link.springer.com/article/10.1038/s41598-020-57638-y
Autor:
Masaaki Kageyama, Kei Tashiro, Masaaki Sasaoka, Koji Ohashi, Masahiro Fuwa, Ryuichi Sato, Masami Tanaka
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
In addition to its role in the treatment of pancreatitis, the serine protease inhibitor nafamostat exhibits a retinal protective effect. However, the exact mechanisms underlying this effect are unknown. In this study, the neuroprotective effects of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a0c052d98845b40008383c85029bd0
https://pubmed.ncbi.nlm.nih.gov/31892740
https://pubmed.ncbi.nlm.nih.gov/31892740
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217945 (2019)
PLoS ONE, Vol 14, Iss 5, p e0217945 (2019)
Chemical proteasome inhibition has been a valuable animal model of neurodegeneration to uncover roles for the ubiquitin-proteasome system in the central nervous system. However, little is known about the effects of chemical proteasome inhibitors on r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcb3aa27b8bdac59d4f34534db10194
https://pubmed.ncbi.nlm.nih.gov/31150519
https://pubmed.ncbi.nlm.nih.gov/31150519
Autor:
Makoto Araie, Masamitsu Shimazawa, Yasushi Ito, Masaaki Sasaoka, Hideaki Hara, Katsuki Nakamura
Publikováno v:
Experimental Eye Research. 86:770-782
Monkey eyes are useful for ophthalmologic research into eye diseases because their histological and functional properties are very similar to those of humans. The monkey laser-induced high intraocular pressure (IOP) model is a common model for ophtha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692e6d0ee5b22be76b970ec5a15ccbe9
https://doi.org/10.1016/j.exer.2008.02.004
https://doi.org/10.1016/j.exer.2008.02.004
Publikováno v:
The Journal of Antibiotics. 60:674-681
Stachybotrydial, a triprenyl phenol metabolite from a fungus, has a plasminogen modulator activity selective to Glu-plasminogen. Stachybotrydial enhanced fibrin binding and activation of Glu-plasminogen (2- to 4-fold enhancement at 60� 120 m M) but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa89e0c3725e072f79dae49ebcf5bb35
https://doi.org/10.1038/ja.2007.86
https://doi.org/10.1038/ja.2007.86
Autor:
Masaaki Sasaoka, Naruhiro Ishida, Atsushi Shimazaki, Masamitsu Shimazawa, Takazumi Taniguchi, Hideaki Hara
Publikováno v:
Experimental Eye Research. 83:629-637
The purpose of this study was to investigate the time course of the ocular hypoperfusion, retinal damage, and optic nerve damage induced by intravitreal injection of endothelin-1 (ET-1) in rabbits. ET-1, at 5 pmol (20 microL, twice a week for 2 or 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7aec71245612b45dbf456c62516181
https://doi.org/10.1016/j.exer.2006.03.007
https://doi.org/10.1016/j.exer.2006.03.007
Autor:
Masaaki Sasaoka, Hideaki Hara, Takazumi Taniguchi, Masamitsu Shimazawa, Goji Tomita, Yoshiaki Kitazawa, Makoto Araie
Publikováno v:
Experimental Eye Research. 82:427-440
We examined the time course of changes in optic disc structure by means of a scanning laser ophthalmoscope (Heidelberg Retina Tomograph, HRT) in ocular hypertensive (experimental glaucoma) monkeys, and clarified the relationships between the histolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bc645075f2201d63fdd863d48aefa5
https://doi.org/10.1016/j.exer.2005.08.001
https://doi.org/10.1016/j.exer.2005.08.001