Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Masaaki Oyama"'
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Yoshikazu Yuki, Shiho Kurokawa, Kotomi Sugiura, Koji Kashima, Shinichi Maruyama, Tomoyuki Yamanoue, Ayaka Honma, Mio Mejima, Natsumi Takeyama, Masaharu Kuroda, Hiroko Kozuka-Hata, Masaaki Oyama, Takehiro Masumura, Rika Nakahashi-Ouchida, Kohtaro Fujihashi, Takashi Hiraizumi, Eiji Goto, Hiroshi Kiyono
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
We previously established the selection-marker-free rice-based oral cholera vaccine (MucoRice-CTB) line 51A for human use by Agrobacterium-mediated co-transformation and conducted a double-blind, randomized, placebo-controlled phase I trial in Japan
Externí odkaz:
https://doaj.org/article/7b4a2074dd93404f8d74acfa66ff2b73
Autor:
Seina Ohe, Yuji Kubota, Kiyoshi Yamaguchi, Yusuke Takagi, Junichiro Nashimoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoichi Furukawa, Mutsuhiro Takekawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Growth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer.
Externí odkaz:
https://doaj.org/article/25151774c4324719bb372acd2dd5e18f
Autor:
Kiyoshi Yamaguchi, Saya Nakagawa, Akari Saku, Yumiko Isobe, Rui Yamaguchi, Paul Sheridan, Kiyoko Takane, Tsuneo Ikenoue, Chi Zhu, Masashi Miura, Yuya Okawara, Satoru Nagatoishi, Hiroko Kozuka-Hata, Masaaki Oyama, Susumu Aikou, Yuka Ahiko, Dai Shida, Kouhei Tsumoto, Satoru Miyano, Seiya Imoto, Yoichi Furukawa
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106563- (2023)
Summary: Bromodomain-containing protein 8 (BRD8) is a subunit of the NuA4/TIP60-histone acetyltransferase complex. Although BRD8 has been considered to act as a co-activator of the complex, its biological role remains to be elucidated. Here, we uncov
Externí odkaz:
https://doaj.org/article/40eae7249af94873810670d3565eb286
Autor:
Ryota Miyashita, Atsuya Nishiyama, Weihua Qin, Yoshie Chiba, Satomi Kori, Norie Kato, Chieko Konishi, Soichiro Kumamoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoshitaka Kawasoe, Toshiki Tsurimoto, Tatsuro S Takahashi, Heinrich Leonhardt, Kyohei Arita, Makoto Nakanishi
Publikováno v:
eLife, Vol 12 (2023)
UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation of PAF15 (PAF15Ub2), which regulates the localization and activation of DNMT1 at DNA methy
Externí odkaz:
https://doaj.org/article/d7c74f44e17c4bfa90ecba39af08c77b
Autor:
Akihiro Tanaka, Tomomi Nakano, Kento Watanabe, Kazutoshi Masuda, Gen Honda, Shuichi Kamata, Reitaro Yasui, Hiroko Kozuka-Hata, Chiho Watanabe, Takumi Chinen, Daiju Kitagawa, Satoshi Sawai, Masaaki Oyama, Miho Yanagisawa, Takekazu Kunieda
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001780 (2022)
Tardigrades are able to tolerate almost complete dehydration by entering a reversible ametabolic state called anhydrobiosis and resume their animation upon rehydration. Dehydrated tardigrades are exceptionally stable and withstand various physical ex
Externí odkaz:
https://doaj.org/article/6d429528361a4d5db6190332612ca6af
Autor:
Hiroko Kozuka-Hata, Tomoko Hiroki, Naoaki Miyamura, Aya Kitamura, Kouhei Tsumoto, Jun-ichiro Inoue, Masaaki Oyama
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 979 (2023)
Abnormal expression of histone deacetylases (HDACs) is reported to be associated with angiogenesis, metastasis and chemotherapy resistance regarding cancer in a wide range of previous studies. Suberoylanilide hydroxamic acid (SAHA) is well known to f
Externí odkaz:
https://doaj.org/article/0845311f48da417e939aac800dde0ee3
Autor:
Ai Sasou, Yoshikazu Yuki, Ayaka Honma, Kotomi Sugiura, Koji Kashima, Hiroko Kozuka-Hata, Masanori Nojima, Masaaki Oyama, Shiho Kurokawa, Shinichi Maruyama, Masaharu Kuroda, Shinjiro Tanoue, Narushi Takamatsu, Kohtaro Fujihashi, Eiji Goto, Hiroshi Kiyono
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background We have previously developed a rice-based oral vaccine against cholera diarrhea, MucoRice-CTB. Using Agrobacterium-mediated co-transformation, we produced the selection marker–free MucoRice-CTB line 51A, which has three copies o
Externí odkaz:
https://doaj.org/article/7aaaddf9d20e428fb3829ef245994d4d
Autor:
Ryo Takano, Hiroko Kozuka-Hata, Daisuke Kondoh, Hiroki Bochimoto, Masaaki Oyama, Kentaro Kato
Publikováno v:
iScience, Vol 19, Iss , Pp 703-714 (2019)
Summary: The pathogenesis of malaria parasites depends on host erythrocyte modifications that are facilitated by parasite proteins exported to the host cytoplasm. These exported proteins form a trafficking complex in the host cytoplasm that transport
Externí odkaz:
https://doaj.org/article/6885f6e74dfd449d9bc269c42507cf92
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Motile cilia and flagella require ATP for their formation and function. Although glycolytic enzymes are components of flagellar proteomes, how they translocate to flagella is unknown. Here we show that the expression pattern of the functiona
Externí odkaz:
https://doaj.org/article/87eab07d7ea649fbac3a3e3884346a1f