Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Masaaki OKAMOTO"'
Autor:
Masaaki Okamoto, Ayumi Kuratani, Daisuke Okuzaki, Naganori Kamiyama, Takashi Kobayashi, Miwa Sasai, Masahiro Yamamoto
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Bleomycin (BLM) induces lung injury, leading to inflammation and pulmonary fibrosis. Regulatory T cells (Tregs) maintain self-tolerance and control host immune responses. However, little is known about their involvement in the pathology of pulmonary
Externí odkaz:
https://doaj.org/article/af5988d247a44f0cbaefcdd64998ba2e
Autor:
Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B. Wing, Shimon Sakaguchi, Masahiro Yamamoto
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112813- (2023)
Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions. Here, to determine the roles of T-bet-expressing Treg cells, we generate a mouse strain
Externí odkaz:
https://doaj.org/article/039174eb253942a08c8589cb37a7924c
Autor:
Momoka Nakashima, Kana Ishikawa, Aika Fugiwara, Kaiin Shu, Yoshimi Fukushima, Masaaki Okamoto, Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Human papilloma virus (HPV) vaccine is currently the most effective prophylaxis to prevent cervical cancer. However, concerns regarding its potential severe adverse reactions have limited the vaccination rate. HPV vaccines have been determin
Externí odkaz:
https://doaj.org/article/bca120a95fc14916a0fbc270900c67e0
Surrogate modeling of waveform response using singular value decomposition and Bayesian optimization
Publikováno v:
Journal of Advanced Mechanical Design, Systems, and Manufacturing, Vol 15, Iss 2, Pp JAMDSM0018-JAMDSM0018 (2021)
In the early stage of vehicle development, it is required to implement a target cascading study by solving inverse problems. However, simulation costs of vehicle dynamics to predict transient responses and frequency responses make the target cascadin
Externí odkaz:
https://doaj.org/article/0e597354e8dd48a4bc2ae8f6d040d868
Autor:
Takahisa Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima, Misako Matsumoto, Tsukasa Seya, Hiroyuki Oshiumi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract RIG-I and MDA5 are cytoplasmic viral RNA sensors that belong to the RIG-I-like receptors (RLRs), which induce antiviral innate immune responses, including the production of type I interferon and other pro-inflammatory cytokines. After recogn
Externí odkaz:
https://doaj.org/article/9be71f73eb1d49e9a5dea918b6fa101c
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1961-1970.e4 (2019)
Summary: Excessive innate immune response is harmful to the host, and aberrant activation of the cytoplasmic viral RNA sensors RIG-I and MDA5 leads to autoimmune disorders. ZNF598 is an E3 ubiquitin ligase involved in the ribosome quality control pat
Externí odkaz:
https://doaj.org/article/d9b4c1acee734a8c91154139e319cb08
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
RIG-I is a pattern recognition receptor and recognizes cytoplasmic viral double-stranded RNA (dsRNA). Influenza A virus, hepatitis C virus, and several other pathogenic viruses are mainly recognized by RIG-I, resulting in the activation of the innate
Externí odkaz:
https://doaj.org/article/5bfa54ddba224d6889e3c320304d61f1
Autor:
Masato Nakai, Hiroyuki Oshiumi, Kenji Funami, Masaaki Okamoto, Misako Matsumoto, Tsukasa Seya, Naoya Sakamoto
Publikováno v:
Sensors, Vol 15, Iss 10, Pp 27160-27173 (2015)
Hepatitis C virus (HCV) infects hepatocytes but not dendritic cells (DCs), but DCs effectively mature in response to HCV-infected hepatocytes. Using gene-disrupted mice and hydrodynamic injection strategy, we found the MAVS pathway to be crucial for
Externí odkaz:
https://doaj.org/article/567da0ed4bb7473ea4aa724dcfcfb0c5
Autor:
Hiroyuki Oshiumi, Moeko Miyashita, Masaaki Okamoto, Yuka Morioka, Masaru Okabe, Misako Matsumoto, Tsukasa Seya
Publikováno v:
Cell Reports, Vol 11, Iss 8, Pp 1193-1207 (2015)
RIG-I-mediated type I interferon (IFN) production and nuclease-mediated viral RNA degradation are essential for antiviral innate immune responses. DDX60 is an IFN-inducible cytoplasmic helicase. Here, we report that DDX60 is a sentinel for both RIG-I
Externí odkaz:
https://doaj.org/article/ff51c26564ba408392f245becaae018f
Autor:
Masaaki OKAMOTO, Jun HONNA
Publikováno v:
Journal of Current Southeast Asian Affairs, Vol 33, Iss 1, Pp 3-6 (2014)
This special issue attempts to go beyond short essays and conduct a deeper analysis of Jakarta’s local politics. Some of the contributions show the peculiarities of Jakartan politics, while others identify similarities with other local politic
Externí odkaz:
https://doaj.org/article/81f6d2ef14e84c2eba9008339b434596