Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Masaaki Kakehi"'
Autor:
Rika Ishikawa, Kosuke Saito, Hidehisa Tachiki, Ryoya Goda, Koji Arai, Hisao Shimizu, Tomohiro Andou, Kentaro Takahara, Hitoshi Uchiyama, Shin-ichiro Nitta, Masaaki Kakehi, Kozo Hayashi, Naohiro Katagiri, Keiko Kojima, Hisashi Fujita, Kazuhiro Tsuchinaga, Yoshiro Saito
Publikováno v:
Bioanalysis. 15:207-218
Background: Although the fit-for-purpose approach has been proposed for biomarker assay validation, practical data should be compiled to facilitate the predetermination of acceptance criteria. Methods: Immunoaffinity LC–MS was used to analyze gluca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee4a4f140e7c2d73421b053b810cca6f
https://doi.org/10.4155/bio-2022-0240
https://doi.org/10.4155/bio-2022-0240
Publikováno v:
ACS Chemical Neuroscience. 14:609-618
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db37afacb492f19d7261a7b6cf10bf51
https://doi.org/10.1021/acschemneuro.2c00370
https://doi.org/10.1021/acschemneuro.2c00370
Autor:
Tomoya Sano, Tadahiro Shinozawa, Takeshi Watanabe, Hironobu Yasuno, Yasushi Masuda, Masaaki Kakehi
Publikováno v:
Toxicological Sciences
Neurotoxicity is a principal concern in nonclinical drug development. However, standardized and universally accepted fluid biomarkers for evaluating neurotoxicity are lacking. Increasing clinical evidence supports the potential use of neurofilament l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565f96cc9b2303cd149e6a6e1feff245
https://doi.org/10.1093/toxsci/kfab122
https://doi.org/10.1093/toxsci/kfab122
Autor:
Yuchen Sun, Shin-ichiro Nitta, Kosuke Saito, Ryuta Hosogai, Keiko Nakai, Ryoya Goda, Hisao Shimizu, Hisashi Fujita, Masaaki Kakehi, Kazuyuki Murata, Takeru Yamaguchi, Takeshi Okuzono, Shinichi Yamane, Mitsuhiko Kawabata, Takayuki Matsunuma, Kentaro Takahara, Noriko Kato, Masaki Yamada, Tokuyuki Yoshida, Takao Inoue, Yoshiro Saito
Publikováno v:
Bioanalysis. 14(18)
Background: Many bioanalytical methods for antisense oligonucleotides (ASOs) using LC–MS have been reported. However, no data have been available on the reproducibility and robustness of a single bioanalytical method for ASOs. As such, in the curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05130eab8441e7d0a6a649cd46a4ec4
https://pubmed.ncbi.nlm.nih.gov/36408704
https://pubmed.ncbi.nlm.nih.gov/36408704
Autor:
Rui Ohashi, Takahiro Nakamura, Yoshiro Saito, Kosuke Saito, Seiji Tanaka, Masaaki Kakehi, Tamiki Mori, Hiroyuki Kakuo, Ryosuke Nakamura, Mizuki Horiuchi, Hiroyuki Yokoi, Harue Igarashi, Hiroyuki Shimizu, Masataka Katashima, Yoshiaki Ohtsu, Yutaka Yasuda, Takashige Okayama
Publikováno v:
Bioanalysis. 13(18)
Biomarkers are an important drug developmental tool. Assessment of quantitative analytical methods of biomarkers is not included in any regulatory documents in Japan. Use of biomarkers in clinical evaluations and supporting the post-marketing evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198984677fd35bab0bdf6925ce824de6
https://pubmed.ncbi.nlm.nih.gov/34517750
https://pubmed.ncbi.nlm.nih.gov/34517750
Autor:
Takeru Yamaguchi, Yoshiaki Ohtsu, Tomoko Arakawa, Hisanori Hara, Hiroshi Kamimori, Yoshihisa Sano, Sakiko Suzuki, Masaaki Kakehi, Hitoshi Uchiyama, Masanari Mabuchi, Yosuke Kawai, Junji Komaba, Jun Hosogi, Harue Igarashi, Akemi Nagao, Takahiro Nakamura, Yumi Nishiguchi, Keiko Nakai
Publikováno v:
Bioanalysis. 11:1303-1308
The Japan Bioanalysis Forum Symposium was held on 12–14 February 2019 (Yokohama, Japan), in celebration of its 10th anniversary, and over 370 participants from pharmaceutical industries, contractors, academia and regulatory authorities from home an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76126b557a963e4dbbf15dfdc244410
https://doi.org/10.4155/bio-2019-0174
https://doi.org/10.4155/bio-2019-0174
Autor:
Seiji Tanaka, Takahiro Nakamura, Yoshiro Saito, Yoshiaki Ohtsu, Masaaki Kakehi, Ryosuke Nakamura, Masanari Mabuchi, Takayoshi Suzuki, Hiroyuki Kakuo, Masataka Katashima, Noriko Katori, Takehisa Matsumaru
Publikováno v:
Bioanalysis. 11:55-60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a8992c402dd4dd036c895751a9247a
https://doi.org/10.4155/bio-2018-0257
https://doi.org/10.4155/bio-2018-0257
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:467-478
The purpose of this study was to investigate the effect of the concentration-dependent erythrocyte distribution of TAK-802, a potent acetylcholinesterase inhibitor, on rat pharmacokinetics. In an ascending oral dose study, the maximum plasma concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5346c666e30061ad8cfd8a2f750411bf
https://doi.org/10.1002/bdd.2029
https://doi.org/10.1002/bdd.2029
Publikováno v:
Biopharmaceuticsdrug disposition. 37(8)
The purpose of this study was to investigate the effect of the concentration-dependent erythrocyte distribution of TAK-802, a potent acetylcholinesterase inhibitor, on rat pharmacokinetics. In an ascending oral dose study, the maximum plasma concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fb2ff9a42a84dc4926e92057f264900
https://pubmed.ncbi.nlm.nih.gov/27554287
https://pubmed.ncbi.nlm.nih.gov/27554287
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:S33-S34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40ea7e1e11b41509158286833714e2f4
https://doi.org/10.1016/j.dmpk.2016.10.146
https://doi.org/10.1016/j.dmpk.2016.10.146