Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Masa-Aki Shibata"'
Autor:
Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa-Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, Tsuyoshi Yamamoto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Off-target interactions between antisense oligonucleotides (ASOs) with state-of-the-art modifications and biological components still pose clinical safety liabilities. To mitigate a broad spectrum of off-target interactions and enhance the s
Externí odkaz:
https://doaj.org/article/f91d43d20dee49279cc0568179bd731f
Autor:
Jun Arima, Kohei Taniguchi, Nobuhiko Sugito, Kazuki Heishima, Yoshihisa Tokumaru, Yosuke Inomata, Kazumasa Komura, Tomohito Tanaka, Masa-Aki Shibata, Sang-Woong Lee, Yukihiro Akao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102079- (2023)
Replenishing tumor-suppressor miRNAs (TS-miRNAs) is a potential next-generation nucleic acid–based therapeutic approach. Establishing an effective miRNA delivery system is essential to successful TS-miRNA therapy. To overcome vulnerability to RNA n
Externí odkaz:
https://doaj.org/article/7b66e61b743a46dbb834022e28a5558d
Autor:
Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa-Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, Tsuyoshi Yamamoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/aa9e0af933084a88b819bfb9ce7cf440
Autor:
Masa-Aki Shibata, Kohei Taniguchi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7123 (2023)
Cancer metastasis is a common biological phenomenon observed in malignant tumors that can lead to death in affected individuals [...]
Externí odkaz:
https://doaj.org/article/543e3eaeded44859ba9bb4790ed6b62b
Autor:
Minoru Numata, Akane Hirano, Yukika Yamamoto, Michiko Yasuda, Nobuhiko Miura, Kazutoshi Sayama, Masa-Aki Shibata, Tomohiro Asai, Naoto Oku, Noriyuki Miyoshi, Kayoko Shimoi
Publikováno v:
Journal of Circadian Rhythms, Vol 19, Iss 1 (2021)
Epidemiological studies have indicated that a disturbed circadian rhythm resulting from night-shift work is a potential risk factor for breast cancer. However, the mechanism of increased risk of breast cancer by night-shift work remains unclear, and
Externí odkaz:
https://doaj.org/article/04e209f79b64459b8c60ccc245e848e8
Autor:
Masa-Aki Shibata, Mariko Harada-Shiba, Eiko Shibata, Hideki Tosa, Yoshinobu Matoba, Hitomi Hamaoka, Munekazu Iinuma, Yoichi Kondo
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1722 (2019)
Lifestyle choices play a significant role in the etiology of atherosclerosis. Male Apoe−/− mice that develop spontaneous atherosclerotic lesions were fed 0%, 0.3%, and 0.4% mangosteen extracts, composed largely of α-mangostin (MG), for 17 weeks.
Externí odkaz:
https://doaj.org/article/3a9b1c751db3452aa2563de4a46b27a0
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 4, Iss 2, Pp 112-120 (2002)
Existing prostate cancer cell lines have been derived from late stages of human prostate cancer. In this paper, we present two cell lines generated from prostatic intraepithelial neoplasia (PIN), the precursor lesion for prostate adenocarcinoma. Pr-1
Externí odkaz:
https://doaj.org/article/bce14c95552b4fd5aa30b59b8f56f1a6
Autor:
Tsuyoshi Yamamoto, Mariko Harada-Shiba, Moeka Nakatani, Shunsuke Wada, Hidenori Yasuhara, Keisuke Narukawa, Kiyomi Sasaki, Masa-Aki Shibata, Hidetaka Torigoe, Tetsuji Yamaoka, Takeshi Imanishi, Satoshi Obika
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonuc
Externí odkaz:
https://doaj.org/article/2e206c7e3b2d4e9f9e1170bbf0385502
Autor:
Shunsuke Wada, Satoshi Obika, Masa-Aki Shibata, Tsuyoshi Yamamoto, Moeka Nakatani, Tetsuji Yamaoka, Hidetaka Torigoe, Mariko Harada-Shiba
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Recent advances in RNA interference (RNAi)-based drug development have partially allowed systemic administration of these agents in vivo with promising therapeutic effects. However, before chemically modified small-interfering RNAs (siRNAs) can be ap
Externí odkaz:
https://doaj.org/article/e86975754e8c46c49ca32490e0716c35
Publikováno v:
International Journal of Breast Cancer, Vol 2011 (2011)
Lymphangiogenesis and the expression of vascular endothelial cell growth factor C (VEGF-C) in tumors have been considered to be causally promoting lymphatic metastasis. There are only a few studies on lymphatic metastasis in immunocompetent allograft
Externí odkaz:
https://doaj.org/article/7a373da168a34644862514f1053a1bfb