Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Masa Cemazar"'
Publikováno v:
Expert Opinion on Drug Discovery. 7:179-194
Cyclotides are plant-made defence proteins with a head-to-tail cyclic backbone combined with a conserved, six cystine knot. They have a range of biological activities, including uterotonic and anti-HIV activity, which have attracted attention to thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1968d9c76a89d27973234a97ab94c9
https://doi.org/10.1517/17460441.2012.661554
https://doi.org/10.1517/17460441.2012.661554
Publikováno v:
Biopolymers. 92:35-43
We recently isolated a protein disulfide isomerase (PDI) from the Rubiaceae (coffee family) plant Oldenlandia affinis (OaPDI) and demonstrated that it facilitates the production of disulfide-knotted defense proteins called cyclotides. PDIs are major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41eab7023caf9910ee43a7269f3a7aa
https://doi.org/10.1002/bip.21113
https://doi.org/10.1002/bip.21113
Publikováno v:
Antioxidants & Redox Signaling. 10:103-112
Cyclic cystine knot proteins are small but topologically complex molecules that occur naturally in plants and have a wide range of bioactivities that make them interesting from a pharmaceutical perspective. Their remarkable stability is dependent on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1bc78f0ba92d1394f1c14b84a0b41d
https://doi.org/10.1089/ars.2007.1849
https://doi.org/10.1089/ars.2007.1849
Autor:
Rosemary F Renda, Marilyn A. Anderson, David J. Craik, Richard J. Clark, Masa Cemazar, Christian W. Gruber, Tomohisa Horibe
Publikováno v:
Journal of Biological Chemistry. 282:20435-20446
We have isolated a protein-disulfide isomerase (PDI) from Oldenlandia affinis (OaPDI), a coffee family (Rubiaceae) plant that accumulates knotted circular proteins called cyclotides. The novel plant PDI appears to be involved in the biosynthesis of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e8f04ba0ee57594b2c4b9816a366ab
https://doi.org/10.1074/jbc.m700018200
https://doi.org/10.1074/jbc.m700018200
Autor:
Kai Pong Lo, David J. Craik, Norelle L. Daly, Masa Cemazar, Sara Häggblad, Ernie Yulyaningsih
Publikováno v:
Journal of Biological Chemistry. 281:8224-8232
The aim of this work was to elucidate the oxidative folding mechanism of the macrocyclic cystine knot protein MCoTI-II. We aimed to investigate how the six-cysteine residues distributed on the circular backbone of the reduced unfolded peptide recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0769ba651603abe6a38d810ce08cca23
https://doi.org/10.1074/jbc.m513399200
https://doi.org/10.1074/jbc.m513399200
Publikováno v:
Journal of Biological Chemistry. 279:16697-16705
Oxidative folding is the fusion of native disulfide bond formation with conformational folding. This complex process is guided by two types of interactions: first, covalent interactions between cysteine residues, which transform into native disulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c52489b71c626d1e6073b544176856
https://doi.org/10.1074/jbc.m312328200
https://doi.org/10.1074/jbc.m312328200
Autor:
Christopher M. Dobson, P. J. Hore, Masa Cemazar, Charles E. Lyon, Jakob J. Lopez, Kiminori Maeda
Publikováno v:
Journal of Biomolecular NMR. 16:235-244
Two new techniques offering considerable improvements in the quality of 1H photo-CIDNP spectra of proteins are demonstrated. Both focus on the problem of progressive photo-degradation of the flavin dye used to generate polarization in exposed tryptop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96212c0d8679fc97464fa6d26853cab7
https://doi.org/10.1023/a:1008351128089
https://doi.org/10.1023/a:1008351128089
Autor:
Sotir Zahariev, Ilona Hudáky, Zoltán Gáspári, Sándor Pongor, András Perczel, Oliviero Carugo, Masa Cemazar
Publikováno v:
Protein Engineering Design and Selection. 16:637-639
The formation of a disulfide bond between adjacent cysteine residues is accompanied by the formation of a tight turn of the protein backbone. In nearly 90% of the structures analyzed a type VIII turn was found. The peptide bond between the two cystei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a8e4b16d47b5980026a31404ec5991
https://doi.org/10.1093/protein/gzg088
https://doi.org/10.1093/protein/gzg088
Publikováno v:
Current topics in medicinal chemistry. 12(14)
Cyclic peptides typically have much higher stability and improved biopharmaceutical properties over their linear counterparts. Our work focuses on the discovery of naturally occurring disulfide-rich cyclic peptides and their applications in drug desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edeffa03bafe95ad5d4cfe5885471aaa
https://pubmed.ncbi.nlm.nih.gov/22827522
https://pubmed.ncbi.nlm.nih.gov/22827522
Autor:
David J. Craik, K. Johan Rosengren, Masa Cemazar, Conan K. Wang, Peta J. Harvey, Richard J. Clark
Publikováno v:
Biochemistry. 50(19)
Cyclotides are a family of plant defense proteins with a unique cyclic backbone and cystine knot. Their remarkable stability under harsh thermal, enzymatic, and chemical conditions, combined with their range of bioactivities, including anti-HIV activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882a1bc959a1c09f3b15d20bbb91a975
https://pubmed.ncbi.nlm.nih.gov/21466163
https://pubmed.ncbi.nlm.nih.gov/21466163