Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Masa Aleckovic"'
Autor:
Jesse M McFarland, Masa Aleckovic, George Coricor, Sangeetha Srinivasan, Matthew Tso, John Lee, Tri-Hung Nguyen, Jose M Mejia Oneto
The Click Activated Protodrugs Against Cancer (CAPACTM) platform enables activation of powerful cancer drugs at tumor sites, maximizing efficacy and minimizing systemic toxicity. CAPAC utilizes a potent click chemistry reaction between tetrazine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea8400fee1c2192475cd05c97cad3c25
https://doi.org/10.1101/2023.03.28.534625
https://doi.org/10.1101/2023.03.28.534625
Autor:
Masa Aleckovic, Sangeetha Srinivasan, Jesse McFarland, Leslie Priddy, Matthew Tso, Jose Mejia Oneto
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b3d075f4355b7367397d97e664905e7
https://doi.org/10.1136/jitc-2022-sitc2022.0953
https://doi.org/10.1136/jitc-2022-sitc2022.0953
Autor:
George Coricor, Jesse M. McFarland, Masa Aleckovic, Sangeetha Srinivasan, John Lee, Leslie Priddy, Matthew Tso, Tri-Hung Nguyen, Jose M. Mejia Oneto
Publikováno v:
Cancer Research. 83:4934-4934
Click chemistry is a Nobel Prize winning technology that has been widely used in research across the life sciences. Shasqi’s Click Activated Protodrugs Against Cancer (CAPACTM) platform is pioneering the therapeutic application of click chemistry r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::394ad7fa7096aef28ad450144769c80e
https://doi.org/10.1158/1538-7445.am2023-4934
https://doi.org/10.1158/1538-7445.am2023-4934
Autor:
Masa Aleckovic, Sangeetha Srinivasan, Jesse M McFarland, Leslie Priddy, Matthew Tso, Jose M Mejia Oneto
Publikováno v:
Cancer Immunology Research. 10:B43-B43
SQ3370, the lead investigational asset of the CAPACTM (Click Activated Protodrugs Against Cancer) platform, is a therapeutic based on doxorubicin which can induce immunogenic cell death in mouse tumors making it a suitable candidate for combination a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34861fd5b890121aa99ea5de9dd93531
https://doi.org/10.1158/2326-6074.tumimm22-b43
https://doi.org/10.1158/2326-6074.tumimm22-b43
Publikováno v:
Clinical Cancer Research. 28:A029-A029
Conventional chemotherapies lack specificity for tumor tissue, have a low therapeutic index, and induce systemic toxicities including cardiomyopathy. SQ3370 utilizes the Click Activated Protodrugs Against Cancer (CAPAC) platform to localize doxorubic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39b6a1f3be0c1bff928741c106ec6e71
https://doi.org/10.1158/1557-3265.sarcomas22-a029
https://doi.org/10.1158/1557-3265.sarcomas22-a029
Autor:
Sant P. Chawla, Kathleen Batty, Masa Aleckovic, Vivek Bhadri, Nam Bui, Alexander David Guminski, Jose Manuel Mejia Oneto, Sangeetha Srinivasan, James Fredric Strauss, Vivek Subbiah, Mia C. Weiss, Rosalind Wilson, Nathan A. Yee, Michael Zakharian, Vineet Kwatra
Publikováno v:
Journal of Clinical Oncology. 40:3085-3085
3085 Background: SQ3370, a novel therapy, utilizes Shasqi’s proprietary Click Activated Protodrugs Against Cancer (CAPAC) platform where mutually-reactive click chemistry groups release Doxorubicin (Dox) at the tumor site minimizing systemic exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d62e37e9b298031c626a959a2039b9f5
https://doi.org/10.1200/jco.2022.40.16_suppl.3085
https://doi.org/10.1200/jco.2022.40.16_suppl.3085
Autor:
Bojana Jovanović, Daniel Temko, Laura E. Stevens, Marco Seehawer, Anne Fassl, Katherine Murphy, Jayati Anand, Kodie Garza, Anushree Gulvady, Xintao Qiu, Nicholas W. Harper, Veerle W. Daniels, Huang Xiao-Yun, Jennifer Y. Ge, Maša Alečković, Jason Pyrdol, Kunihiko Hinohara, Shawn B. Egri, Malvina Papanastasiou, Raga Vadhi, Alba Font-Tello, Robert Witwicki, Guillermo Peluffo, Anne Trinh, Shaokun Shu, Benedetto Diciaccio, Muhammad B. Ekram, Ashim Subedee, Zachary T. Herbert, Kai W. Wucherpfennig, Anthony G. Letai, Jacob D. Jaffe, Piotr Sicinski, Myles Brown, Deborah Dillon, Henry W. Long, Franziska Michor, Kornelia Polyak
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113564- (2023)
Summary: Triple-negative breast cancer (TNBC) is a heterogeneous disease with limited treatment options. To characterize TNBC heterogeneity, we defined transcriptional, epigenetic, and metabolic subtypes and subtype-driving super-enhancers and transc
Externí odkaz:
https://doaj.org/article/5b7a46fb42fa443eac6a172b0b60048f
Autor:
Maša Alečković, Simona Cristea, Carlos R. Gil Del Alcazar, Pengze Yan, Lina Ding, Ethan D. Krop, Nicholas W. Harper, Ernesto Rojas Jimenez, Donghao Lu, Anushree C. Gulvady, Pierre Foidart, Marco Seehawer, Benedetto Diciaccio, Katherine C. Murphy, Jason Pyrdol, Jayati Anand, Kodie Garza, Kai W. Wucherpfennig, Rulla M. Tamimi, Franziska Michor, Kornelia Polyak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and
Externí odkaz:
https://doaj.org/article/1cad67a83e124a70947f561786bfe0e4
Autor:
Masa, Aleckovic, David, Carter
Publikováno v:
Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fd18fce15752dae6267d9e7a761ee24
https://pubmed.ncbi.nlm.nih.gov/19771236
https://pubmed.ncbi.nlm.nih.gov/19771236
Autor:
Lina Ding, Ying Su, Anne Fassl, Kunihiko Hinohara, Xintao Qiu, Nicholas W. Harper, Sung Jin Huh, Noga Bloushtain-Qimron, Bojana Jovanović, Muhammad Ekram, Xiaoyuan Zi, William C. Hines, Maša Alečković, Carlos Gil del Alcazar, Ryan J. Caulfield, Dennis M. Bonal, Quang-De Nguyen, Vanessa F. Merino, Sibgat Choudhury, Gabrielle Ethington, Laura Panos, Michael Grant, William Herlihy, Alfred Au, Gedge D. Rosson, Pedram Argani, Andrea L. Richardson, Deborah Dillon, D. Craig Allred, Kirsten Babski, Elizabeth Min Hui Kim, Charles H. McDonnell, Jon Wagner, Ron Rowberry, Kristie Bobolis, Celina G. Kleer, E. Shelley Hwang, Joanne L. Blum, Simona Cristea, Piotr Sicinski, Rong Fan, Henry W. Long, Saraswati Sukumar, So Yeon Park, Judy E. Garber, Mina Bissell, Jun Yao, Kornelia Polyak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Myoepithelial cells prevent tumour growth and invasion in DCIS. Here, the authors show that p63 and TCF7 cooperate to regulate a transcription factor network for the maintenance of normal myoepithelial function and altered expression of these genes p
Externí odkaz:
https://doaj.org/article/784cf49197cf4d50824d3974f6c39d75