Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marzoni, Gifford"'
Autor:
Jesus Ernesto Villafranca, Carol L. J. Booth, Charlotte A. Bartlett, Stephanie Webber, Cindy L. Palmer, C. A. Morse, Varney Michael D, Ellen W. Moomaw, Jones Terence R, S. M. Herrmann, Krzysztof Appelt, Kathleen K. Lewis, Katharine M. Welsh, Robert William Ward, Cheryl Ann Janson, Russell J. Bacquet, Eleanor F. Howland, Ward W. Smith, Stephen E. Webber, Vinit Kathardekar, David A. Matthews, Jennifer White, Marzoni Gifford P
Publikováno v:
Journal of Medicinal Chemistry. 39:904-917
To develop novel lipophilic thymidylate synthase (TS) inhibitors, the X-ray structure of Escherichia coli TS in ternary complex with FdUMP and the inhibitor 10-propargyl-5,8-dideazafolic acid (CB3717) was used as a basis for structure-based design. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f33e515142229b5c112750e718425e0
https://doi.org/10.1021/jm9502652
https://doi.org/10.1021/jm9502652
Publikováno v:
Synthetic Communications. 25:2475-2482
N-Cbz-(S-phenyl)-L-cysteine (3) has been prepared on a multi-kilogram scale in high yield and optical purity from the β-lactone of N-Cbz-L-serine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9036b6efc3527f006152b5b850653c1
https://doi.org/10.1080/00397919508015453
https://doi.org/10.1080/00397919508015453
Autor:
Eleanor F. Howland, S. H. Reich, J. White, Varney Michael D, Marzoni Gifford P, S. M. Herrmann, C. A. Morse, Robert William Ward, Carol L. J. Booth, K. M. Welsh, Nguyen Dzuy Nguyen Dzuy, Charlotte A. Bartlett, Stephanie Webber
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d99c365643afe3712636b0bce672a42
https://doi.org/10.1002/chin.199303159
https://doi.org/10.1002/chin.199303159
Publikováno v:
ChemInform. 26
N-Cbz-(S-phenyl)-L-cysteine (3) has been prepared on a multi-kilogram scale in high yield and optical purity from the β-lactone of N-Cbz-L-serine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d71abfbdbff457847c00dc962d468f60
https://doi.org/10.1002/chin.199543240
https://doi.org/10.1002/chin.199543240
Autor:
C. A. Morse, Deal Judith G, Marzoni Gifford P, Russell J. Bacquet, Varney Michael D, Katherine M. Welsh, Cynthia Louise Palmer, Carol L. J. Booth, Charlotte A. Bartlett, Stephanie Webber
Publikováno v:
Journal of Medicinal Chemistry. 35:663-676
The X-ray crystal-structure-based design, synthesis, and biological activity of a novel family of benz[cd]indole-containing inhibitors of thymidylate synthase (TS) are described. The structure-activity of the lead compound was studied by conceptually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da667eaf66267ac58f91fe9da8375545
https://doi.org/10.1021/jm00082a006
https://doi.org/10.1021/jm00082a006
Autor:
Marlene L. Cohen, Kathleen R. Whitten, Jerry W. Misner, Marzoni Gifford P, William L. Garbrecht
Publikováno v:
Journal of Medicinal Chemistry. 33:652-656
A series of (8 beta)-6-methylergoline amide derivatives was synthesized with various alkyl substituents in the N1-position in order to evaluate their effectiveness in blocking vascular 5HT2 receptors. The influence of both the N1 substituent and amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124f46d93da8a39c6b9823d48fd344c2
https://doi.org/10.1021/jm00164a029
https://doi.org/10.1021/jm00164a029
Autor:
Marzoni, Gifford, Kaldor, Stephen W., Trippe, Anthony J., Shamblin, Brian M., Fritz, James E.
Publikováno v:
Synthetic Communications; Aug1995, Vol. 25 Issue 16, p2475-2482, 8p
Autor:
Marzoni, Gifford
Publikováno v:
Journal of Heterocyclic Chemistry; Mar1986, Vol. 23 Issue 2, p577-580, 4p
Publikováno v:
Journal of Labelled Compounds & Radiopharmaceuticals; Apr1988, Vol. 25 Issue 4, p429-438, 10p
Publikováno v:
Journal of medicinal chemistry. 31(2)
A series of (8 beta)-6-methyl-1-(1-methylethyl)ergoline-8-carboxylic acid cycloalkyl esters were prepared and examined for blockade of vascular 5HT2 receptors. The antagonist in this series that had the highest 5HT2 receptor affinity was (8 beta)-6-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a6f221ef47c6716d6c62b92ee4c4c6
https://pubmed.ncbi.nlm.nih.gov/3339614
https://pubmed.ncbi.nlm.nih.gov/3339614