Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marzia Villa"'
Autor:
Eun Kyung Lee, Pravin Iyer, Sandra Steiner, Matthew C. Lucas, Ryan Craig Schoenfeld, Hai-Ying Cai, David S. Carter, Robert James Weikert, Marzia Villa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4630-4633
A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbbdaed6bc94e709f0bbe772f9fd531
https://doi.org/10.1016/j.bmcl.2009.06.076
https://doi.org/10.1016/j.bmcl.2009.06.076
Publikováno v:
Tetrahedron. 61:10801-10810
The malfunctioning of protein kinases is a hallmark of numerous diseases, for which a satisfactory therapy is missing. We describe the design and synthesis of a kinase targeted library based on a novel 2-(3-phenyl-1H-pyrazol-4-yl)-1,3-benzoxazole sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0978afef237124a5b93ef6cb77f199d0
https://doi.org/10.1016/j.tet.2005.08.070
https://doi.org/10.1016/j.tet.2005.08.070
Publikováno v:
Organic & Biomolecular Chemistry. 1:247-250
A four step synthesis of 4(S)-oxazolidineacetic acid, 2-oxo benzyl ester (D-Oxac-OBn) from L-Asp-OH in 45% overall yield is reported. The formation of by-products is completely avoided, by microwave irradiation and by the use of caesium carbonate as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d473e58d435440d30f46e194bdbee398
https://doi.org/10.1039/b210725m
https://doi.org/10.1039/b210725m
Autor:
Alessandra Barazza, Fernando Formaggio, Marco Crisma, Marzia Villa, Claudio Toniolo, Claudia Tomasini, Bernard Kaptein, Quirinus B. Broxterman, Herbert Mayrhofer, Cristina Peggion, Peter Pöchlauer
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :644-651
By a chemo-enzymatic approach we performed a large-scale, stereoselective synthesis of the Cα-methylated α-hydroxy acid L-(αMe)Hyv. We also prepared model depsipeptides based on this sterically demanding residue in combination with the α-amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c246d8c0f58292dceb80b3a77d9b67
https://doi.org/10.1039/b107691b
https://doi.org/10.1039/b107691b
Publikováno v:
Tetrahedron. 55:8103-8110
The diastereoselective addition of higher order (H.O.) cuprates and zinc-copper reagents to aliphatic and aromatic chiral imines derived from ( S )-1-phenylethylamine was examined. Aliphatic chiral imines react with (Allyl) 2 CuCNLi 2 and (n-Bu) 2 Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557c9b676f042eefc98527546c3679b8
https://doi.org/10.1016/s0040-4020(99)00418-4
https://doi.org/10.1016/s0040-4020(99)00418-4
Publikováno v:
ChemInform. 29
A general approach to the solution phase parallel synthesis of perhydrooxazin-4-ones, which allows the preparation of milligram quantities of each individual member, is reported. An efficient purification method, using as “Sequestration Enabling Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c21a57d8b0da391cc1fa814a59e87425
https://doi.org/10.1002/chin.199848161
https://doi.org/10.1002/chin.199848161
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4a415f869a43ce45d66f7ef7cb8a295
https://doi.org/10.1002/chin.199847113
https://doi.org/10.1002/chin.199847113
Publikováno v:
ChemInform. 30
The diastereoselective addition of higher order (H.O.) cuprates and zinc-copper reagents to aliphatic and aromatic chiral imines derived from ( S )-1-phenylethylamine was examined. Aliphatic chiral imines react with (Allyl) 2 CuCNLi 2 and (n-Bu) 2 Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d45e7858b2d015086d889f1e849c489
https://doi.org/10.1002/chin.199940053
https://doi.org/10.1002/chin.199940053
Autor:
Anthony W. Thompson, Shelley K. Gleason, David S. Carter, Michael Patrick Dillon, Yansheng Zhai, Anthony P.D.W. Ford, Joel R Gever, Amy Geraldine Moore, Christine E. Brotherton-Pleiss, Clara Jeou Jen Lin, Marzia Villa
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
Despite the extensive literature describing the role of the ATP-gated P2X 3 receptors in a variety of physiological processes the potential of antagonists as therapeutic agents has been limited by the lack of drug-like selective molecules. In this pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466f55626358f5c2c249a164fd47abc5
https://pubmed.ncbi.nlm.nih.gov/20045645
https://pubmed.ncbi.nlm.nih.gov/20045645
Autor:
Eun Kyung Lee, Ralf Roetz, Clara Jeou Jen Lin, Jason Choy, Amy Geraldine Moore, Sandra Steiner, Kerem Erol Ozboya, Yansheng Zhai, Robert James Weikert, Karin Ann Stein, David S. Carter, Stephen M. Lynch, Matthew C. Lucas, Ann Marie Madera, Pravin Iyer, Hai-Ying Cai, Saul Jaime-Figueroa, Robert Greenhouse, Lubica Raptova, Ryan Craig Schoenfeld, Linda M. Bannwart, Marzia Villa
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro microsomal stability and in vitro permeability, and low drug-drug interaction potential are desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84114b6169c0bc75e13b7bfee4fda1f
https://pubmed.ncbi.nlm.nih.gov/18954985
https://pubmed.ncbi.nlm.nih.gov/18954985