Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marzia Tartari"'
Autor:
Emilio Di Maria, Antonella Marasco, Marzia Tartari, Paola Ciotti, Giovanni Abbruzzese, Giuseppe Novelli, Emilia Bellone, Elena Cattaneo, Paola Mandich
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 274-279 (2006)
Huntington's disease (HD) is a late-onset, autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion. The number of repeats on the HD chromosome explains most of the variability in age of onset, but genetic factors other th
Externí odkaz:
https://doaj.org/article/b8cc9b5a1a974f8ab3140cda7b5a55eb
Autor:
Marzia Tartari, Valentina Lo Sardo, Binia Drung, James A. Walker, Franco Cotelli, Barbara Vitali, Catarina Ramos, Scott Zeitlin, Anna Pistocchi, Elena Cattaneo, Germano Gaudenzi, Marta Valenza, Boris Schmidt, Luciano Conti, Chiara Zuccato, James F. Gusella, Michael A. Myre
Publikováno v:
Nature Neuroscience. 15:713-721
The Huntington's disease gene product, huntingtin, is indispensable for neural tube formation, but its role is obscure. We studied neurulation in htt-null embryonic stem cells and htt-morpholino zebrafish embryos and found a previously unknown, evolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2fe3d3cb9f8acc3fac376ca75ec12a
https://doi.org/10.1038/nn.3080
https://doi.org/10.1038/nn.3080
Autor:
Marzia Tartari, Dmitry Lim, Laura Fedrizzi, Chiara Zuccato, Ernesto Carafoli, Elena Cattaneo, Marisa Brini
Publikováno v:
Journal of Biological Chemistry. 283:5780-5789
Dysfunctions of Ca2+ homeostasis and of mitochondria have been studied in immortalized striatal cells from a commonly used Huntington disease mouse model. Transcriptional changes in the components of the phosphatidylinositol cycle and in the receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becf3ec79b23c1bdc08bd3dbe849b8c6
https://doi.org/10.1074/jbc.m704704200
https://doi.org/10.1074/jbc.m704704200
Autor:
Manuela Marullo, Elena Cattaneo, Chiara Zuccato, Marzia Tartari, Marcy E. MacDonald, Paola Conforti
Publikováno v:
Brain Pathology. 18:225-238
One cardinal feature of Huntington's disease (HD) is the degeneration of striatal neurons, whose survival greatly depends on the binding of cortical brain-derived neurotrophic factor (BDNF) with high-affinity (TrkB) and low-affinity neurotrophin rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838c4146fa4ada60a8faa1c6d3ef94f7
https://doi.org/10.1111/j.1750-3639.2007.00111.x
https://doi.org/10.1111/j.1750-3639.2007.00111.x
Autor:
Elisa Fossale, Paola Conforti, Evangelia Papadimou, Marcy E. MacDonald, Marzia Tartari, Elena Cattaneo, Lezanne Ooi, Chiara Zuccato, Noel J. Buckley, Nikolai D. Belyaev, Scott Zeitlin
Publikováno v:
Journal of Neuroscience. 27:6972-6983
Huntingtin is a protein that is mutated in Huntington's disease (HD), a dominant inherited neurodegenerative disorder. We previously proposed that, in addition to the gained toxic activity of the mutant protein, selective molecular dysfunctions in HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f58da369f929bbdcc0b6bea73c14ba
https://doi.org/10.1523/jneurosci.4278-06.2007
https://doi.org/10.1523/jneurosci.4278-06.2007
Autor:
Emilia Bellone, Paola Mandich, Giuseppe Novelli, Antonella Marasco, Marzia Tartari, Paola Ciotti, Elena Cattaneo, Giovanni Abbruzzese, Emilio Di Maria
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 274-279 (2006)
Huntington's disease (HD) is a late-onset, autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion. The number of repeats on the HD chromosome explains most of the variability in age of onset, but genetic factors other th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dddc81373f46dd58136147679a4e912
https://doi.org/10.1016/j.nbd.2006.07.002
https://doi.org/10.1016/j.nbd.2006.07.002
Publikováno v:
Nature Reviews Neuroscience. 6:919-930
Several neurological diseases are characterized by the altered activity of one or a few ubiquitously expressed cell proteins, but it is not known how these normal proteins turn into harmful executors of selective neuronal cell death. We selected hunt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f77f0f7d1bc59cd85e4aa0b5a0c783
https://doi.org/10.1038/nrn1806
https://doi.org/10.1038/nrn1806
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease
Autor:
Marzia Tartari, Chiara Zuccato, Marta Valenza, Dorotea Rigamonti, Elena Cattaneo, Donato Goffredo
Publikováno v:
Pharmacological Research. 52:140-150
Huntington's Disease (HD) is a neurodegenerative disorder caused by an abnormally expanded polyglutamine trait in the amino-terminal region of huntingtin. Pathogenic mechanisms involve a gained toxicity of mutant huntingtin and a potentially reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8208a8d6b1015d65c9d5433d0e6131d
https://doi.org/10.1016/j.phrs.2005.01.006
https://doi.org/10.1016/j.phrs.2005.01.006
Publikováno v:
Annals of the New York Academy of Sciences. 1049:39-50
The identification of intracellular molecules and soluble factors that are important for neuronal differentiation and survival are of critical importance for development of therapeutic strategies for brain diseases. First, the activity of these facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e671a64ddf33391d6c61f256587a39
https://doi.org/10.1196/annals.1334.006
https://doi.org/10.1196/annals.1334.006
Autor:
Michael R. Hayden, Blair R. Leavitt, Donato Goffredo, Andrea Crotti, Dorotea Rigamonti, Tõnis Timmusk, Tiziana Cataudella, Marzia Tartari, Marta Valenza, Chiara Zuccato, Luciano Conti, Elena Cattaneo
Publikováno v:
Nature Genetics. 35:76-83
Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates transcription of the gene encoding brain-derived neurotrophic factor (BDNF; ref. 2). Here we show that the neuron restrict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f89314057d283ee15e5f431753eb16
https://doi.org/10.1038/ng1219
https://doi.org/10.1038/ng1219