Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marzia Munafò"'
Autor:
Sonia Coni, Federica A Falconio, Marta Marzullo, Marzia Munafò, Benedetta Zuliani, Federica Mosti, Alessandro Fatica, Zaira Ianniello, Rosa Bordone, Alberto Macone, Enzo Agostinelli, Alessia Perna, Tanja Matkovic, Stephan Sigrist, Gabriella Silvestri, Gianluca Canettieri, Laura Ciapponi
Publikováno v:
eLife, Vol 10 (2021)
Microsatellite expansions of CCTG repeats in the cellular nucleic acid-binding protein (CNBP) gene leads to accumulation of toxic RNA and have been associated with myotonic dystrophy type 2 (DM2). However, it is still unclear whether the dystrophic p
Externí odkaz:
https://doaj.org/article/e2297eac8cb54bc882d8e8ccac2b6c5b
Autor:
Marzia Munafò, Victoria R Lawless, Alessandro Passera, Serena MacMillan, Susanne Bornelöv, Irmgard U Haussmann, Matthias Soller, Gregory J Hannon, Benjamin Czech
Publikováno v:
eLife, Vol 10 (2021)
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo. Composed of multiple copies of ~30 different nucleoporins (Nups), the NPC acts as a selective portal, interacting wit
Externí odkaz:
https://doaj.org/article/6b6faff476fb481f814cc489979dcd57
Autor:
Evelyn L Eastwood, Kayla A Jara, Susanne Bornelöv, Marzia Munafò, Vasileios Frantzis, Emma Kneuss, Elisar J Barbar, Benjamin Czech, Gregory J Hannon
Publikováno v:
eLife, Vol 10 (2021)
In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions. In Drosophila ovaries, piRNA-loaded Piwi detects nascent transposon transcripts and ins
Externí odkaz:
https://doaj.org/article/8c72a5d9b9b2465db0cee631acd9807f
Autor:
Martin H Fabry, Filippo Ciabrelli, Marzia Munafò, Evelyn L Eastwood, Emma Kneuss, Ilaria Falciatori, Federica A Falconio, Gregory J Hannon, Benjamin Czech
Publikováno v:
eLife, Vol 8 (2019)
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptiona
Externí odkaz:
https://doaj.org/article/849bc140c7d04436961cec2abdc1d62a
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1861-1873 (2016)
Mutations in the 3′-5′ exonuclease DIS3L2 are associated with Perlman syndrome and hypersusceptibility to Wilms tumorigenesis. Previously, we found that Dis3l2 specifically recognizes and degrades uridylated pre-let-7 microRNA. However, the wides
Externí odkaz:
https://doaj.org/article/c4bbba5dc82b4ca3a9c8a3a2394078a8
Chromatin modifications are linked with regulating patterns of gene expression, but their causal role and context-dependent impact on transcription remains unresolved. Here, we develop a modular epigenome editing platform that programmes nine key chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3769f0029d39634d07adbad52d0dd328
https://doi.org/10.1101/2022.09.04.506519
https://doi.org/10.1101/2022.09.04.506519
Autor:
Benedetta Zuliani, Zaira Ianniello, Alessandro Fatica, Marta Marzullo, Alberto Macone, Alessia Perna, Rosa Bordone, Gabriella Silvestri, Marzia Munafò, Tanja Matkovic, Enzo Agostinelli, Stephan J. Sigrist, Federica A Falconio, Sonia Coni, Federica Mosti, Laura Ciapponi, Gianluca Canettieri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dbec7de4bc0ebf02cd83801c532f525
https://doi.org/10.7554/elife.69269.sa2
https://doi.org/10.7554/elife.69269.sa2
Autor:
Marzia Munafò, Jonathan B. Preall, Benjamin Czech, Emma Kneuss, Evelyn L Eastwood, Undine-Sophie Deumer, Gregory J. Hannon
Publikováno v:
Genes & Development. 33:1208-1220
The PIWI-interacting RNA (piRNA) pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilization. In Drosophila ovaries, most piRNAs originate from dual-strand clusters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14e0ed01ecaf920991ccc5cff919981f
https://doi.org/10.1101/gad.328690.119
https://doi.org/10.1101/gad.328690.119
Publikováno v:
Nature structural & molecular biology
Ribosomal RNA (rRNA) biogenesis is a multistep process requiring several nuclear and cytoplasmic exonucleases. The exact processing steps for mammalian 5.8S rRNA remain obscure. Here, using loss-of-function approaches in mouse embryonic stem cells (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab72b0610858259fc815d87186e9df10
http://europepmc.org/articles/PMC6554070
http://europepmc.org/articles/PMC6554070
Autor:
Victoria R Lawless, Marzia Munafò, Susanne Bornelöv, Alessandro Passera, Irmgard U. Haussmann, Matthias Soller, Serena MacMillan, Gregory J. Hannon, Benjamin Czech
Publikováno v:
eLife, Vol 10 (2021)
Funder: Biotechnology and Biological Sciences Research Council; FundRef: http://dx.doi.org/10.13039/501100000268
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo.
The nuclear pore complex (NPC) is the principal gateway between nucleus and cytoplasm that enables exchange of macromolecular cargo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be1f26756ba83dbab81cf70f2d5fe05