Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Marzia Martina"'
Autor:
Marzia Martina, Umberto Banderali, Alvaro Yogi, Mehdi Arbabi Ghahroudi, Hong Liu, Traian Sulea, Yves Durocher, Greg Hussack, Henk van Faassen, Balu Chakravarty, Qing Yan Liu, Umar Iqbal, Binbing Ling, Etienne Lessard, Joey Sheff, Anna Robotham, Debbie Callaghan, Maria Moreno, Tanya Comas, Dao Ly, Danica Stanimirovic
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Genetic studies have identified the voltage‐gated sodium channel 1.7 (Nav1.7) as pain target. Due to the ineffectiveness of small molecules and monoclonal antibodies as therapeutics for pain, single‐domain antibodies (VHHs) are developed
Externí odkaz:
https://doaj.org/article/25473da9710e4c68b7eed6b4056350ba
Autor:
Alp Ozgun, David J. Lomboni, Amy Aylsworth, Allison Macdonald, William A. Staines, Marzia Martina, Michael G. Schlossmacher, Joseph S. Tauskela, John Woulfe, Fabio Variola
Publikováno v:
Materials Today Bio, Vol 25, Iss , Pp 100992- (2024)
Modern in vitro technologies for preclinical research, including organ-on-a-chip, organoids- and assembloid-based systems, have rapidly emerged as pivotal tools for elucidating disease mechanisms and assessing the efficacy of putative therapeutics. I
Externí odkaz:
https://doaj.org/article/d2bae2e1d0ce40cf9af33ace061c32c7
Autor:
Chris V Bowen, Drew DeBay, H Stephen Ewart, Pamela Gallant, Sean Gormley, T Toney Ilenchuk, Umar Iqbal, Tyler Lutes, Marzia Martina, Geoffrey Mealing, Nadine Merkley, Sandra Sperker, Maria J Moreno, Christopher Rice, Raymond T Syvitski, John M Stewart
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58866 (2013)
Soricidin is a 54-amino acid peptide found in the paralytic venom of the northern short-tailed shrew (Blarina brevicauda) and has been found to inhibit the transient receptor potential of vallinoid type 6 (TRPV6) calcium channels. We report that two
Externí odkaz:
https://doaj.org/article/35c52c9afae442ebb022516fdad112ea
Autor:
Willard J. Costain, Salma Alasmar, Umberto Banderali, Maria Ribecco-Lutkiewicz, Caroline Sodja, Marzia Martina, Slavisa Corluka, Amy Aylsworth, Anna Jezierski, Ewa Baumann, Joseph S. Tauskela
Publikováno v:
Stem cell reviews and reports. 18(1)
Human induced pluripotent stem cell (iPSC)-derived neurons are of interest for studying neurological disease mechanisms, developing potential therapies and deepening our understanding of the human nervous system. However, compared to an extensive his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3db1420be71f0b5f172c61cc6ba7f2f
https://pubmed.ncbi.nlm.nih.gov/34687385
https://pubmed.ncbi.nlm.nih.gov/34687385
Autor:
Marguerite Ball, Jez Huang, Anna Jezierski, Danica Stanimirovic, Marzia Martina, Mahmud Bani-Yaghoub, Julie Haukenfrers, Caroline Sodja, Qing Liu, Dao Ly, Maria Ribecco-Lutkiewicz, Peter Zachar, Arsalan S. Haqqani, Marina Rukhlova, Ewa Baumann
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
We have developed a renewable, scalable and transgene free human blood-brain barrier model, composed of brain endothelial cells (BECs), generated from human amniotic fluid derived induced pluripotent stem cells (AF-iPSC), which can also give rise to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3efd5684bf9b096f5f7e9dca85238e6
https://doi.org/10.1038/s41598-018-19522-8
https://doi.org/10.1038/s41598-018-19522-8
Autor:
Willard J. Costain, Marzia Martina, Melissa Hewitt, Amy Aylsworth, Tanya Comas, Xigeng Zhao, Joseph S. Tauskela
Publikováno v:
European journal of pharmacology. 786
Activation of cannabinoid receptor 1 (CB1) inhibits synaptic transmission in hippocampal neurons. The goal of this study was to evaluate the ability of benchmark and emerging synthetic cannabinoids to suppress neuronal activity in vitro using two com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9edf0273de2c8cd109e284ed678166
https://pubmed.ncbi.nlm.nih.gov/27262380
https://pubmed.ncbi.nlm.nih.gov/27262380
Publikováno v:
The Journal of Physiology. 578:143-157
The sigma receptor (σR), once considered a subtype of the opioid receptor, is now described as a distinct pharmacological entity. Modulation of N-methyl-d-aspartate receptor (NMDAR) functions by σR-1 ligands is well documented; however, its mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57efb15301e32dbec57dd05d668adb51
https://doi.org/10.1113/jphysiol.2006.116178
https://doi.org/10.1113/jphysiol.2006.116178
Autor:
Mario Tiberi, Richard Bergeron, Samantha Halman, Marzia Martina, Guochuan Tsai, Marie-Eve B. Turcotte, Joseph T. Coyle
Publikováno v:
The Journal of Physiology. 563:777-793
To investigate the effects of persistent elevation of synaptic glycine at Schaffer collateral–CA1 synapses of the hippocampus, we studied the glutamatergic synaptic transmission in acute brain slices from mice with reduced expression of glycine tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dbae2301090de560b12142453b5969c
https://doi.org/10.1113/jphysiol.2004.080655
https://doi.org/10.1113/jphysiol.2004.080655
Autor:
Christopher J. Schmidt, Samantha Halman, John A. Lowe, Marzia Martina, Richard Bergeron, Yelena Gorfinkel, Pranav Periyalwar
Publikováno v:
The Journal of Physiology. 557:489-500
Long-term potentiation (LTP) in the hippocampal CA1 region requires the activation of NMDA receptors (NMDARs). NMDAR activation in turn requires membrane depolarization as well as the binding of glutamate and its coagonist glycine. Previous pharmacol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63b098e2d17c7638e06e381c969551c
https://doi.org/10.1113/jphysiol.2004.063321
https://doi.org/10.1113/jphysiol.2004.063321
Publikováno v:
European Journal of Neuroscience. 15:545-552
The connections of limbic structures are remarkably constant across species. However, different species express fear in distinct ways. Because the central amygdaloid nucleus is considered an important mediator of fear responses, we compared the physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b5033d73434025d6eb8929bf58539bb
https://doi.org/10.1046/j.0953-816x.2001.01879.x
https://doi.org/10.1046/j.0953-816x.2001.01879.x